Digitalni repozitorij raziskovalnih organizacij Slovenije

Iskanje po repozitoriju
A+ | A- | Pomoč | SLO | ENG

Iskalni niz: išči po
išči po
išči po
išči po

Možnosti:
  Ponastavi


Iskalni niz: "ključne besede" (atrioventricular block) .

1 - 2 / 2
Na začetekNa prejšnjo stran1Na naslednjo stranNa konec
1.
Left bundle branch area pacing vs right ventricular pacing for atrioventricular block : the MELOS RELOADED study
Marek Jastrzębski, Grzegorz Kiełbasa, Oscar Cano, Karol Curila, Francesco Zanon, David Žižek, 2026, izvirni znanstveni članek

Povzetek: Background and Aims: Left bundle branch area pacing (LBBAP) promotes physiological synchronous activation of the left ventricle and may be particularly beneficial in patients with atrioventricular block (AVB), but its mortality benefit remains unclear. This study aims to compare long-term survival in AVB patients receiving either LBBAP or right ventricular pacing (RVP) and to analyse predictors of mortality during LBBAP. Methods: MELOS RELOADED, a multicentre European collaboration, was a registry-based study of pacemaker patients with AVB, left ventricular ejection fraction (LVEF) >40% and ventricular pacing >20%. The primary outcome was all-cause mortality based on national registries. A 1:1 propensity score matching was performed between the RVP and LBBAP groups. Kaplan–Meier curves and multivariable Cox proportional hazards models were used to estimate survival. Results: In total, 3382 patients receiving LBBAP or RVP were matched. At 4-year follow-up, the Kaplan–Meier curve showed an absolute difference in survival of 11.8% in favour of LBBAP (P < .001). LBBAP was a robust predictor of reduced mortality with a hazard ratio (HR) of 0.53 (95% confidence interval 0.42–0.65, P < .001). Within the LBBAP group, the following independent predictors of increased mortality were identified: lack of confirmed left bundle branch capture (HR 1.85, P < .001), lower percentage of ventricular pacing (HR 1.12), and age. Conclusions: This is the first large study demonstrating the long-term survival benefit of LBBAP. This strengthens the use of LBBAP in AVB patients with preserved/mildly reduced LVEF while awaiting the results of randomized trials. Confirmation of left bundle branch capture seems advisable to achieve optimal results with LBBAP.
Ključne besede: conduction system pacing, left bundle branch area pacing, atrioventricular block, mortality, heart failure
Objavljeno v DiRROS: 10.04.2026; Ogledov: 1120; Prenosov: 312
.pdf Celotno besedilo (1,22 MB)
Gradivo ima več datotek! Več...

2.
Predictors of stroke volume improvement with AV-optimized conduction system pacing in patients with AV dromotropathy
Anja Zupan Mežnar, Tadej Žlahtič, Miha Mrak, Maja Ivanovski, David Žižek, 2026, drugi znanstveni članki

Povzetek: Aims: Patients with first-degree atrioventricular (AV) block and mechanical AV dyssynchrony can present with heart failure (HF)- like symptoms. AV-optimized conduction system pacing (CSP) can improve haemodynamics and symptoms, but selection criteria remain uncertain. We aimed to identify electrocardiographic and echocardiographic predictors of an acute haemodynamic response to AV-optimized CSP in symptomatic first-degree AV block. Methods and Results: Nineteen patients (mean age 60.5 ± 21.1 years; 37% female) with symptomatic first-degree AV block underwent baseline electrocardiography and echocardiography followed by AV-optimized conduction system pacing and repeat echocardiographic assessment. Electrocardiographic parameters (PR interval, P wave duration/PR interval ratio) and echocardiographic indices (E/A wave confluence, A-Q interval, and DFT/RR ratio) were tested for association with change in left ventricular stroke volume (LVSV). The mean PR interval was 395 ± 61 ms, the mean A-Q interval 155 ± 65 ms, and the mean DFT/RR ratio 0.34 ± 0.1. E/A wave confluence was present in 15 patients (79%). AV-optimized pacing increased LVSV by 7.8 ± 3.9 ml, corresponding to an 11.8 ± 5.7% relative increase (P < .01). Echocardiographic parameters were associated with LVSV response, including A-Q interval (r = 0.63, P = .004), DFT/RR ratio (r = −0.59, P = .008), and E/A wave confluence (r = 0.57, P = .01). Electrocardiographic parameters were not associated with LVSV change. Conclusions: Echocardiographically assessed mechanical AV dyssynchrony, rather than electrocardiographic parameters, is associated with an acute haemodynamic response to pacing. Echocardiographic evaluation may help identify patients with prolonged PR interval who could benefit from AV-optimized CSP.
Ključne besede: atrioventricular dyssynchrony, atrioventricular conduction block, conduction system pacing, atrioventricular optimization
Objavljeno v DiRROS: 08.04.2026; Ogledov: 325; Prenosov: 300
.pdf Celotno besedilo (306,59 KB)
Gradivo ima več datotek! Več...
Iskanje izvedeno v 0.04 sek.
Na vrh