1. Changes in gait and postural control after 10-day bed rest and 30-day recovery : Elektronski virLuka Šlosar, Manca Peskar, Boštjan Šimunič, Rado Pišot, Marco Vincenzo Narici, Uroš Marušič, 2026, izvirni znanstveni članek Povzetek: Background Prolonged bed rest is a well-established model for studying the effects of immobility on functional performance, especially gait and postural control. Understanding how these functions deteriorate and recover across age groups is essential for developing targeted rehabilitation strategies. Research question How does a 10-day horizontal bed rest affect gait performance and postural control in young and older adults, and to what extent do these effects differ by age? Methods Following a multistage screening process from a large pool of healthy male volunteers, ten older men (68.5 ± 2.6 years) and ten young men (22.9 ± 4.7 years) completed 10 days of horizontal bed rest in a controlled laboratory setting, followed by a standardized 30-day recovery program. Postural control and gait speed assessed under self-selected and brisk walking conditions were measured before bed rest, immediately after, and following a 30-day recovery program. Results Following bed rest, self-selected walking speed did not differ significantly from baseline in either group. In contrast, brisk walking speed significantly decreased in older (−11.4%, p < 0.05) and young adults (−9.9%, p < 0.05), with both groups returning to baseline values after recovery. Postural control deteriorated significantly in older adults (-15.5%), whereas no significant difference from baseline was observed in young adults. After baseline adjustment, postural control showed a significant group effect both after bed rest (η² > 0.244) and post-recovery (η² > 0.395). Significance The findings reveal clear age-related differences in responses to inactivity and recovery. Older adults experienced greater impairments and slower restoration of balance, indicating heightened vulnerability to functional decline during periods of immobilization. These findings underscore the age-dependent impact of bed rest and the importance of tailored rehabilitation strategies.
Ključne besede: aging, physical inactivity, mobile body imaging, functional decline
Objavljeno v DiRROS: 24.04.2026; Ogledov: 125; Prenosov: 106
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2. Microstructural evolution and hardness of ferritic superalloys containing NiAl-B2 and ▫$L2_1–Ni_2TiAl$▫ precipitatesAdi Ganda Putra, Selly Septianissa, Pawawoi, Manty Aldilani Ikaningsih, Martoni, Martijanti, Mohammad Zaki Mubarok, Hafizh Ridwanulloh, Jodi Irawan, Ba’adilla Akhista Gamara, 2026, izvirni znanstveni članek Ključne besede: aging, ferritic superalloy, hardness, homogenization, L21–Ni2TiAl, NiAl-B2, SEM, XRD
Objavljeno v DiRROS: 16.04.2026; Ogledov: 173; Prenosov: 96
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3. Telomere length, oxidative stress, and kidney damage biomarkers in Fabry nephropathyTina Levstek, Erazem Bahčič, Bojan Vujkovac, Andreja Cokan Vujkovac, Tine Tesovnik, Žiga Iztok Remec, Vanja Čuk, Katarina Trebušak Podkrajšek, 2025, izvirni znanstveni članek Povzetek: Fabry nephropathy is a life-threatening complication of Fabry disease characterized by complex and incompletely understood pathophysiological processes possibly linked to premature aging. We aimed to investigate leukocyte telomere length (LTL), oxidative stress, and kidney damage biomarkers in relation to kidney function. The study included 35 Fabry patients and 35 age and sex-matched control subjects. Based on the estimated slope of the glomerular filtration rate, the patients were divided into two groups. Relative LTL was quantified by qPCR, urinary biomarkers 8-hydroxy-2′ -deoxyguanosine (8-OHdG) and malondialdehyde (MDA) by UHPLC-MS/MS, and kidney damage biomarkers by flow cytometry. There was no statistically significant difference in LTL between Fabry patients and controls. However, a significant difference was observed in male patients compared to their matched control subjects (p = 0.013). Oxidative stress biomarkers showed no differences between patients and controls, while significant differences were observed in urinary IGFBP7, EGF, and OPN levels between Fabry patients with stable kidney function and those with progressive nephropathy (FDR = 0.021, 0.002, and 0.013, respectively). Significant differences were also observed in plasma levels of cystatin C, TFF3, and uromodulin between patients with progressive nephropathy and controls (all FDR = 0.039). Along with these biomarkers (FDR = 0.007, 0.017, and 0.010, respectively), NGAL also exhibited a significant difference between the two patient groups (FDR = 0.017). This study indicates accelerated telomere attrition, which may be related to disease burden in males. Furthermore, analyses of urinary oxidative stress markers revealed no notable disparities between the different kidney function groups, indicating their limited utility. However, promising differences were found in some biomarkers of kidney damage in urine and plasma.
Ključne besede: nephropathy, telomere length, oxidative stress, kidney damage, biomarker, aging
Objavljeno v DiRROS: 10.04.2026; Ogledov: 148; Prenosov: 103
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4. The application of ultrasound sarcopenia index in sarcopenic populationKatarina Puš, Fabio Sarto, Marco Vincenzo Narici, Boštjan Šimunič, 2026, izvirni znanstveni članek Povzetek: Background: Aging leads to progressive motor system decline, which can result in sarcopenia, defined as the age- related loss of muscle mass and function. Architectural changes, epitomized by a decrease in fascicle length (Lf) and muscle thickness (MT), provide a useful signature of sarcopenia. Their ratio (Lf/MT), named ultrasound sarcopenia index (USI), is a new parameter proposed for evaluating changes in muscle geometric proportions associated with muscle atrophy but lacks application in a sarcopenic population. This study aimed to explore vastus lateralis USI in a sarcopenic population. Methods: In a sample of 139 older adults (54% females), recruited from Italy and Slovenia, we assessed muscle architecture using ultrasound imaging to measure Lf, MT, pennation angle (PA), and USI. We assessed handgrip strength, sit-to-stand test, and physical performance with timed up-and-go and gait speed. Appendicular lean mass was assessed with dual x-ray absorptiometry. Sarcopenia was classified using the EWGSOP2 and SDOC classifications. Results: Sarcopenia prevalence was 15.1% and 30.9% when classified by the EWGSOP2 and SDOC classifications, respectively. Differences in muscle architecture were observed between sarcopenic and non-sarcopenic groups, with MT showing the largest effect size (Cohen's d EWGSOP2: 0.86; SDOC:0.77). USI was higher in sarcopenic compared to non-sarcopenic individuals classified with EWGSOP2 (5.33 ± 1.30 vs 4.59 ± 0.94, p = .011, Cohen's d:0.69), confirming its sensitivity in detecting sarcopenia. Conclusion: We showed that increased USI values are associated with sarcopenia. This study shows USI as a sensitive, non-invasive marker for sarcopenia classification, supporting its use in clinical screening and monitoring of muscle changes in older adults.
Ključne besede: muscle architecture, aging, muscle quality, muscle function
Objavljeno v DiRROS: 26.03.2026; Ogledov: 200; Prenosov: 103
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5. Variability in spatial and temporal gait dynamics during aging : a narrative review on the role of the neural systemChristoph Centner, Ramona Ritzmann, Uroš Marušič, Luke Hughes, 2026, pregledni znanstveni članek Povzetek: Gait dynamics, encompassing both spatial and temporal parameters, undergo significant changes with aging, often leading to increased gait variability and, consequentially, a higher risk of falls. While cognitive and musculoskeletal factors have been demonstrated to contribute to these alterations, the role of the neural system is crucial and yet not fully understood. This review aims to synthesize the existing evidence on the age-related deterioration in locomotor functioning, with a specific emphasis on the neural mechanisms involved. Besides summarizing appropriate measures to quantify gait variability, several neural factors including cortical, neurotransmitter, and sensory system degeneration, are explored as key contributors to the observed changes in locomotion during aging. Additionally, the review discusses the potential use of diverse interventions to enhance gait variability during aging to reduce the risk of falls. By elucidating the complex interplay between aging, gait dynamics, and neural function, this review underscores the importance of targeted interventions aimed at preserving neural health to maintain gait stability and reduce fall risk in the aging population. The findings suggest that further research is needed to develop and refine strategies for the early detection and prevention of gait-related impairments linked to neural decline.
Ključne besede: gait, variability, aging, motor control
Objavljeno v DiRROS: 24.02.2026; Ogledov: 345; Prenosov: 219
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6. Predictors for residential mobility in later life : empirical findings for the young-oldliving in an Austrian small townTatjana Fischer, Markus Jobst, Karl Moder, 2025, izvirni znanstveni članek Povzetek: The article addresses residential mobility in later life from the perspective of the young-old, an under-explored topic in Austria. Data originating from a written survey conducted as part of a cross-sectional case study on people aged 60 to 74 years living in an Austrian small town are used to estimate prospective behaviour using logistic regression. The results show that women and people with a higher educational attainment are more likely to leave their current urban residential municipality, while men are more likely to relocate to a nursing home. Moreover, a duration of residence of 20 or more years decreases the probability of relocation. The findings confirm previous studies and highlight, that more spatially disaggregated data is needed to improve decision-making in town planning.
Ključne besede: spatial research, cross-sectional study, aging in place, residental mobility, attitudes, Austria
Objavljeno v DiRROS: 10.02.2026; Ogledov: 613; Prenosov: 258
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7. Acceptance and perceptions of old age and agingMateja Lorber, 2019, predgovor, uvodnik, spremna beseda Ključne besede: nurses, nursing care, health care, Slovenia, acceptance, elderly, older people, aging, Slovenia
Objavljeno v DiRROS: 28.01.2026; Ogledov: 392; Prenosov: 206
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8. Dietary habits and physical activity patterns among Slovenian elderly : cross-sectional survey with cluster analysisJoca Zurc, Cirila Hlastan-Ribič, Brigita Skela-Savič, 2015, izvirni znanstveni članek Povzetek: Introduction: Physical activity and a healthy diet are significant predictors of healthy ageing-they help the elderly maintain their physical and mental health, and prevent chronic diseases. Methods: The data for the empirical quantitative survey were collected on the sample of 218 elderly community-dwelling participants (aged 65 years or more), using a structured questionnaire for self-reporting. Data analyses were proceed by the bivariate statistics, and multivariate hierarchical cluster analysis. Results: Most respondents reported good dietary habits (83.1 %) and a satisfactory physical activity level (60.5 %). On average, the elderly eat 3-4 meals per day (59.8 %) and engage in physical activity at least three times a week (58.6 %), with interventions lasting 15 minutes or more (84.4 %) and non-organized activities were prevailing (96.2 %). Ward's method yielded three clusters with homogenous dietary and physical activity patterns: 'Health Consciousness' (30.8 %), 'Being At Risk' (42.7 %) and 'Special Requirements' (26.5 %). Discussion and conclusion: In the future, special attention should be placed on the elderly group with special dietary and physical activity requirements. Additional studies on representative samples are required for a comprehensive investigation into the lifestyle behaviours of elderly individuals.
Ključne besede: lifestyle, elderly, aging factors, health promotion, cluster analysis
Objavljeno v DiRROS: 28.01.2026; Ogledov: 316; Prenosov: 172
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10. Effect of deep cryogenic treatment on aging behavior and properties of Al-Mg-Si alloyBojan Podgornik, Matic Klug Jovičević, Patricia Jovičević Klug, 2023, objavljeni znanstveni prispevek na konferenci Ključne besede: deep cryogenic treatment, Al-Mg-Si alloy, aging, microstructure, hardness, fatigue
Objavljeno v DiRROS: 08.07.2025; Ogledov: 655; Prenosov: 379
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