1. Integrating genetic insights, technological advancements, screening, and personalized pharmacological interventions in childhood obesityRobert Šket, Barbara Slapnik, Primož Kotnik, Klementina Črepinšek, Barbara Čugalj Kern, Tine Tesovnik, Barbara Jenko Bizjan, Blaž Vrhovšek, Žiga Iztok Remec, Maruša Debeljak, Tadej Battelino, Jernej Kovač, 2025, pregledni znanstveni članek Povzetek: Childhood obesity is a significant global health challenge with rising prevalence over the past 50 years, affecting both immediate and long-term health outcomes. The increase in prevalence from 0.7% to 5.6% in girls and 0.9% to 7.8% in boys highlights the urgency of addressing this epidemic. By 2025, it is estimated that 206 million children and adolescents aged 5–19 years will be living with obesity. This review explores the complex interplay of genomics and genetics in pediatric obesity, transitioning from monogenic and polygenic obesity to epigenetics, and incorporating advancements in omics technologies. The evolutionary purpose of adiposity, systemic evaluation of hyperphagia, and the role of various genetic factors are discussed. Technological advancements in genotyping offer new insights and interventions. The integration of genetic screening into clinical practice for early identification and personalized treatment strategies is emphasized.
Ključne besede: hemophilia, wearable, Florio HAEMO, adherence, patient satisfaction
Objavljeno v DiRROS: 27.11.2025; Ogledov: 105; Prenosov: 59
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2. A synthesis of evidence for policy from behavioural science during COVID-19 : analysisKai Ruggeri, Friederike Stock, S. Alexander Haslam, Valerio Capraro, Žan Lep, 2024, izvirni znanstveni članek Povzetek: Scientifc evidence regularly guides policy decisions1 , with behavioural science increasingly part of this process2 . In April 2020, an infuential paper3 proposed 19 policy recommendations (‘claims’) detailing how evidence from behavioural science could contribute to eforts to reduce impacts and end the COVID-19 pandemic. Here we assess 747 pandemic-related research articles that empirically investigated those claims. We report the scale of evidence and whether evidence supports them to indicate applicability for policymaking. Two independent teams, involving 72 reviewers, found evidence for 18 of 19 claims, with both teams fnding evidence supporting 16 (89 %) of those 18 claims. The strongest evidence supported claims that anticipated culture, polarization and misinformation would be associated with policy efectiveness. Claims suggesting trusted leaders and positive social norms increased adherence to behavioural interventions also had strong empirical support, as did appealing to social consensus or bipartisan agreement. Targeted language in messaging yielded mixed efects and there were no efects for highlighting individual benefts or protecting others. No available evidence existed to assess any distinct diferences in efects between using the terms ‘physical distancing’ and ‘social distancing’. Analysis of 463 papers containing data showed generally large samples; 418 involved human participants with a mean of 16,848 (median of 1,699). That statistical power underscored improved suitability of behavioural science research for informing policy decisions. Furthermore, by implementing a standardized approach to evidence selection and synthesis, we amplify broader implications for advancing scientifc evidence in policy formulation and prioritization.
Ključne besede: psychology, behaviour, trusted leaders, adherence to behavioural interventions, covid-19, pandemic
Objavljeno v DiRROS: 27.01.2025; Ogledov: 556; Prenosov: 313
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3. The effectiveness of neuromuscular training warm-up program for injury preventionin adolescent male basketball playersArmin Paravlić, Peter Bakalár, Katarina Puš, Saša Pišot, Miloš Kalc, Kaja Teraž, Luka Šlosar, Manca Peskar, Uroš Marušič, Boštjan Šimunič, 2024, izvirni znanstveni članek Povzetek: This study evaluated the effects of a neuromuscular training (NMT) warm-up program on injury incidence,neuromuscular function, and program adherence, maintenance and acceptance in adolescent basketballplayers. A total of 275 players from 20 Slovenian teams (15 ± 1.7 years of age), were randomized into anintervention group (IG, n=129) and a control group (CG, n=146). Over three months, the IG incorporatedNMT into their warm-ups, while the CG followed their usual practice. Measurements of body anthro-pometry, muscle contractile properties, and balance were taken before and after the intervention. Also,the injury incidence, training adherence and maintenance were reported. Both groups showed improvedbalance, with no significant difference between them. However, IG demonstrated reduced delay times inspecific muscles, indicating improved neuromuscular function. Injury prevalence proportion (%) duringthe whole study period was higher in the control group compared to intervention (IG: 10.9% vs. CG:23.3%), and incidence rate. Moreover, the incidence rate ratio for sustaining an injury was 2.6 on average(ranging from 0.88 to 7.07 for tendon and muscle injuries, respectively), indicating significantly lowerinjury risk in IG than CG. These findings highlight the effectiveness of NMT warm-ups in reducing injuryrisk and enhancing neuromuscular function, emphasizing the value of structured injury preventionstrategies in youth sports.
Ključne besede: muscle contractile properties, balance, injury prevalence, training adherence
Objavljeno v DiRROS: 18.11.2024; Ogledov: 821; Prenosov: 461
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