Iskanje po repozitoriju

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Povzetek: One of the common European commitments is a transition towards a green circular economy in which waste is not discarded and considered to be just an environmental problem, but should be recognized as an important potential source of raw materials for industry. In a priority order in waste management activities, introduced by the Waste Directive in 2012, recycling is set just behind the waste prevention and reuse. Many types of waste can be recycled, the most perspective being construction, industrial and mining wastes. The latter are produced and disposed of at mine sites during the excavation and processing of ore and are extremely perspective due to large quantities and remaining of different metals, however still underutilized, with low recycling rate. Many mining wastes are inert and do not releases contaminants into environment, however, some of them are problematic and even require monitoring. Reprocessing of these wastes, which include beneficiation and sequential extraction of valuable metals in the first phase and recycling of residues in both structural and civil engineering in the second phase establishes a zero waste model with several benefits for economy, environment and society. Out of the South-East European countries, North Macedonia has great potential to establish this model. As a consequence of long mining tradition and abundant ore resources, there are many mining and metallurgical tailings, on the other hand vivid economy and numerous sinks for use of recycled materials in construction sector can accommodate these quantities. However, there are open questions in terms of administrative procedures and legislation. What are those obstacles that accompany the smooth establishment of the proposed model from a legislative point of view? This paper deals with the situation in North Macedonia, in terms of opportunities, legislative options and the need to adopt new legislation, taking also into account the current problems in this field in Europe.
Ključne besede: circular economy, zero-waste approach, mining waste, construction sector, legislation, krožno gospodarstvo, pristop ničelnega odpadka, rudarski odpadki, gradbeništvo, zakonodaja
Objavljeno v DiRROS: 04.12.2023; Ogledov: 240; Prenosov: 135
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Povzetek: Adolescents present a relevant stakeholder in international migrations since they comprise a large share of all migrants. Previous studies show that migration processes significantly affect the well-being of migrant adolescents. This article investigates how the school environment, with its pedagogical practices and interpersonal relationships established between migrant adolescents, their classmates, and teachers, affect migrant adolescents’ well-being. Our research draws on quantitative data collected as part of the MiCREATE project. The sample of migrant adolescents (N = 700) was surveyed in 46 schools in six countries: Austria, Denmark, Slovenia, Spain, Poland, and the United Kingdom. Results indicate that migrant adolescents like school and feel safe there, however, they tend to be more satisfied with relationships established with teachers than with peers. Furthermore, differences in self-perceived school well-being emerge when comparing countries with a longer tradition of high migration flows (Spain, Denmark, and the United Kingdom) and those less experienced (Poland and Slovenia), although slight exceptions were detected. The results lead to the conclusion that schools that foster intercultural education and fulfilling interpersonal relationships are essential for school well-being of migrant adolescents and present an important step toward successful integration of migrant youth.
Ključne besede: migration, migrant children, well-being, integration, child-centered approach, family, school
Objavljeno v DiRROS: 30.01.2023; Ogledov: 384; Prenosov: 250
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Povzetek: Background: Vismodegib is a first-in-class inhibitor of the hedgehog pathway for treatment of locally advanced basal cell carcinoma (laBCC) and metastatic BCC. Objectives: The purpose of this study is to report outcomes of patients with laBCC, with basal cell carcinoma nevus syndrome (Gorlin Goltz syndrome [G-G Syn]) treated with vismodegib in routine clinical practice in Slovenia in 8.3-year period. Methods: In this retrospective cohort study, we analyzed baseline characteristics, outcomes, and treatment-related adverse events from locally advanced BCC. The patients were divided into two cohorts: 39 laBCC or multiple BCC patients and 7 patients with G-G Syn who were treated with vismodegib from November 2012 till January 2021. Results: During 100-month period, 46 patients were diagnosed with laBCC (26), multiple BCC (13), and G-G Syn (7), all inappropriate for surgery or radiotherapy. Baseline characteristics: median age was 72.8 years in laBCC + multiple BCC cohort and 47.4 years in G-G Syn cohort. The objective response rate was 80% in laBCC + multiple BCC and 86% in G-G Syn cohort. Disease control rate (DCR) was 95% in laBCC + multiple BCC and 100% in G-G Syn cohort. Median duration of treatment was 9.9 months (range: 1.5-43.1) in laBCC and multiple BCC cohort and 19.5 months (range: 3.6-94.1) in G-G Syn cohort. Majority of treatment-emergent adverse events (TEAEs) in laBCC or multiple BCC cohort were grade 1 or 2 (96%), only 4% of AEs were grade 3. Majority of TEAEs in G-G Syn cohort were also grade 1 or 2 (87%), 13% of AEs were grade 3. No grade 4 or 5 vismodegib-related AEs were reported. Conclusion: Vismodegib has shown meaningful efficacy with DCR from 95% to 100% in patients with laBCC, multiple BCC, and G-G Syn in Slovenia. TEAEs were successfully alleviated with multidisciplinary approach and early supportive care.
Ključne besede: basal cell carcinoma, early supportive care, Gorlin Goltz syndrome, multidisciplinary approach
Objavljeno v DiRROS: 07.09.2022; Ogledov: 483; Prenosov: 235
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