1. New insights in ATP synthesis as therapeutic target in cancer and angiogenic ocular diseasesCornelis J. F. van Noorden, Bahar Yetkin-Arik, Paola Serrano Martinez, Noëlle Bakker, Mathilda E. van Breest Smallenburg, Reinier O. Schlingemann, Ingeborg Klaassen, Bernarda Majc, Anamarija Habič, Urban Bogataj, Katrin S. Galun, Miloš Vittori, Mateja Erdani-Kreft, Metka Novak, Barbara Breznik, Vashendriya V. V. Hira, 2024, pregledni znanstveni članek Povzetek: Lactate and ATP formation by aerobic glycolysis, the Warburg effect, is considered a hallmark of cancer. During angiogenesis in non-cancerous tissue, proliferating stalk endothelial cells (ECs) also produce lactate and ATP by aerobic glycolysis. In fact, all proliferating cells, both non-cancer and cancer cells, need lactate for the biosynthesis of building blocks for cell growth and tissue expansion. Moreover, both non-proliferating cancer stem cells in tumors and leader tip ECs during angiogenesis rely on glycolysis for pyruvate production, which is used for ATP synthesis in mitochondria through oxidative phosphorylation (OXPHOS). Therefore, aerobic glycolysis is not a specific hallmark of cancer but rather a hallmark of proliferating cells and limits its utility in cancer therapy. However, local treatment of angiogenic eye conditions with inhibitors of glycolysis may be a safe therapeutic option that warrants experimental investigation. Most types of cells in the eye such as photoreceptors and pericytes use OXPHOS for ATP production, whereas proliferating angiogenic stalk ECs rely on glycolysis for lactate and ATP production. Ključne besede: aerobic glycolysis, anaerobic glycolysis, angiogenesis, ATP synthesis, cancer cells, cancer stem cells, endothelial cells, energy metabolism, eye diseases, oxidative phosphorylation, pericytes, retina, Warburg effect Objavljeno v DiRROS: 18.06.2024; Ogledov: 103; Prenosov: 67
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2. Using the IUCN environmental impact classification for alien taxa to inform decision-makingSabrina Kumschick, Sandro Bertolino, Tim M. Blackburn, Giuseppe Brundu, Katie E. Costello, Maarten De Groot, Thomas Evans, Belinda Gallardo, Piero Genovesi, Tanushri Govender, 2023, izvirni znanstveni članek Povzetek: The Environmental Impact Classification for Alien Taxa (EICAT) is an important tool for biological invasion policy and management and has been adopted as an International Union for Conservation of Nature (IUCN) standard to measure the severity of environmental impacts caused by organisms living outside their native ranges. EICAT has already been incorporated into some national and local decision-making procedures, making it a particularly relevant resource for addressing the impact of non-native species. Recently, some of the underlying conceptual principles of EICAT, particularly those related to the use of the precautionary approach, have been challenged. Although still relatively new, guidelines for the application and interpretation of EICAT will be periodically revisited by the IUCN community, based on scientific evidence, to improve the process. Some of the criticisms recently raised are based on subjectively selected assumptions that cannot be generalized and may harm global efforts to manage biological invasions. EICAT adopts a precautionary principle by considering a species’ impact history elsewhere because some taxa have traits that can make them inherently more harmful. Furthermore, non-native species are often important drivers of biodiversity loss even in the presence of other pressures. Ignoring the precautionary principle when tackling the impacts of non-native species has led to devastating consequences for human well-being, biodiversity, and ecosystems, as well as poor management outcomes, and thus to significant economic costs. EICAT is a relevant tool because it supports prioritization and management of non-native species and meeting and monitoring progress toward the Kunming–Montreal Global Biodiversity Framework (GBF) Target 6. Ključne besede: biological invasions, evidence synthesis, impact assessment, managing invasive species, precautionary principle Objavljeno v DiRROS: 11.12.2023; Ogledov: 462; Prenosov: 273
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3. Correlations between the catalyst properties and catalytic activity of Au on ▫$ZrO_2-CeO_2$▫ in the hydrogenation of ▫$CO_2$▫Hue-Tong Vu, Matjaž Finšgar, Janez Zavašnik, Nataša Novak Tušar, Albin Pintar, 2023, izvirni znanstveni članek Ključne besede: ▫$CO_2$▫ utilization, gold, mixed oxides, amorphous ▫$ZrO_2$▫, methanol synthesis Objavljeno v DiRROS: 16.03.2023; Ogledov: 639; Prenosov: 360
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4. Tailoring water adsorption capacity of APO-TricSuzana Mal, Alenka Ristić, Amalija Golobič, Nataša Zabukovec Logar, 2021, izvirni znanstveni članek Ključne besede: APO-Tric, water adsorption capacity, thermal energy storage, green ionothermal synthesis, single-crystal structure determination Objavljeno v DiRROS: 16.11.2022; Ogledov: 587; Prenosov: 450
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6. Mechanisms of copper-based catalyst deactivation during CO [sub] 2 reduction to methanolAnže Prašnikar, Andraž Pavlišič, Francisco Ruiz-Zepeda, Janez Kovač, Blaž Likozar, 2019, izvirni znanstveni članek Ključne besede: catalyst deactivation, methanol synthesis, deactivation mechanism, modelling Objavljeno v DiRROS: 24.11.2020; Ogledov: 1413; Prenosov: 1030
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7. New insights into manganese local environment in MnS-1 nanocrystalsAlenka Ristić, Matjaž Mazaj, Iztok Arčon, Nina Daneu, Nataša Zabukovec Logar, Roger Gläser, Nataša Novak Tušar, 2019, izvirni znanstveni članek Ključne besede: MnS-1 nanocrystals, Mn XANES, EXAFS, zeolites, microwave-assisted hydrothermal synthesis Objavljeno v DiRROS: 23.11.2020; Ogledov: 12202; Prenosov: 947
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8. Structural and degradation studies of a biocompatible Zn-L-tartrate metal-organic frameworkAna Palčić, Andreas Puškarić, Matjaž Mazaj, Emanuela Žunkovič, Nataša Zabukovec Logar, Josip Bronić, 2015, izvirni znanstveni članek Povzetek: New anhydrous Zn-l-tratrate was synthesized under hydrothermal conditions. Crystal structure which was solved by powder X-ray diffraction data from monoclinic unit cell (I2, a=11.7557(1), b=9.0319(1), c=5.0750(1), β=91.920(1)) consists of the three-dimensional framework where each Zn atom coordinates four tartrate ligands in distorted octahedral geometry. Due to its biocompatible components, the degradation of material was studied in aqueous media under different pH values (pH=1–7) and in the simulated body fluid (pH=7.4) performed by the measurement of the released Zn2+ concentrations at thermostatic conditions (37 °C). The results showed that under acidic conditions approximately 60% of Zn2+ is released from the investigated material after 6 h of degradation process. With the increase of the solution’s pH, the rate of degradation gradually decreases. XRD and SEM analyses indicate that in aqueous media the compound slowly disintegrates and does not undergo hydrolysis process regardless of pH. Biocompatibility of the compound and its controllable rate of degradation even in acid conditions open its potential use in the fields of bio-applications.
Graphical abstract
The degradation kinetics of Zn-l-tar MOF material in aqueous media at different pH conditions.
Full-size image (24 K) Ključne besede: Zn-tartrate, coordination polymers, hydrothermal synthesis, biomedical application, food supplement Objavljeno v DiRROS: 26.01.2015; Ogledov: 5120; Prenosov: 521
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