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Povzetek: Plasma membrane is a heterogeneous structure with several coexisting domains having different fluidity characteristics. It plays an important role in the control of cell growth, differentiation and transformation. Fluidity of the whole plasma membrane reflects the ordering and dynamics of phospholipid acyl chains in specific membrane domains, as well as the fraction of each domain inthe membrane. Changes in the membrane fluidity affect processes on the membrane such as transport, enzyme activities and expression of the redeptors.In this paper we present results of our recent electron paramagneticresonance (EPR) studies of plasma membrane fluidity characteristics, which take into account heterogeneous nature of the plasma membrane, By the computer simulation of the EPR spectra line-shapes, the number of coexisting domains in the plasma membrane, their relative portion inthe membrane as well as the ordering and dynamics of each domain be determined. Therefore, we could distinguish the contribution of the relative portion of each domain from the contribution of fulidity alterations in the domain to the entire fluidity changes in the membrane. Two examples will be discussed: membrane fluidity characteristics of excised lung tumor tissues andinfluence of microtubule depolymerizing agent vinblastine on membrane fluidity of vinblastine sensitive and resistant HeLa cells.
Objavljeno v DiRROS: 19.01.2024; Ogledov: 217; Prenosov: 52
Celotno besedilo (1,91 MB)

Povzetek: Eight of 29 patients with progressive CIN were followed for 2 to 10 years. Their consecutive Pap smears were destained and stained according to Feulgen thionin method. Cyto-Savant/TM high resolution image cytometer (Oncometrics Technol. Corp., Vancouver, Canaderage values of muclear texture features and their probability distributions for consecutive Pap smears from each patient were calculated. Three out of 5 discriminant MAC, highDNAamount, highDNAcomp and highDNAarea, were to increase as a function of time in 5 out of 8 patients. A preliminary analysis which was performed on non-standardized archival material demonstrated a monotonous increase of discrete texture features as a function of time in patients with progressive CIN.
Objavljeno v DiRROS: 19.01.2024; Ogledov: 222; Prenosov: 61
Celotno besedilo (1,39 MB)

Povzetek: The construction sector is recognised as having a key impact on the life on Earth. Consequently, the EU has set clear environmental goals for 2030 and 2050, and is developing policies and tools to achieve them. One of the tools for achieving these goals is to establish a system for the evaluation of the environmental performance of buildings, with the priorities of reducing GHG emissions, saving with natural resources and preserving the environment, while maintaining sustainable development and ensuring a healthy living environment. Slovenia has joined in achieving this goal with a study on the state-of-play, commissioned a few years ago by the Ministry of the Environment and Spatial Planning, as the starting point for the development of sustainable building indicators (SBIs). The research, which included an analysis of the Slovenian legislation, commercial certification systems for sustainable buildings and development in the field of green public procurement, exposed complementary but rather different goals and views. It further showed that the Level(s), which provides a common EU approach in assessing the environmental performance of buildings, seems to be the most appropriate framework and the basis for the development of the Slovenian system of SBIs. The development of the Slovenian SBIs is currently underway within the project LIFE IP CARE4CLIMATE with the preparation of guidelines, data sources and procedures for determining the value of individual indicators for the assessment of buildings. Initial research with key construction stakeholders has shown that the solution must be linked to the national building legislation, computational methods and software tools, and also to the established planning procedures. The analyses have also shown that, parallel to developing such a system, it is essential to provide a functional supporting environment and a specific, purposely designed information platform to connect the stakeholders with the developers of the sustainable building indicators system.
Ključne besede: sustainable building indicators, evaluation, assessment, Level(s), CARE4CLIMATE
Objavljeno v DiRROS: 19.01.2024; Ogledov: 232; Prenosov: 110
Celotno besedilo (18,89 MB)
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Povzetek: Non-native tree species – defined as those species intentionally or unintentionally introduced by humans – have long been a part of the Alpine Space, providing numerous benefits, but also posing a potential threat to native biodiversity and related ecosystem services. Compared to the urban space where non-native trees comprise most tree species, the number of non-native trees in forests and plantations is relatively low. To evaluate potential risks and benefits of non-native trees in the Alpine Space, a transnational strategy for the responsible use and management of non-native trees is needed. The goals of the strategy are to tailor management practices for a sustainable and responsible use or admixture of non-native trees, to reduce the risks connected with the invasive potential of some non-native tree species, to help forests and urban areas to adapt to climate change, and to improve coordination and cooperation regarding best practices between different regions of the Alpine Space. A proposal was developed in a four-step process including expert-based assessment, stakeholder mapping, an extensive data review, and a public consultation. For implementing the strategy fully, strong collaboration among diverse stakeholders is anticipated and robust governance and an adequate long-term and fair funding scheme is needed.
Ključne besede: adaptive forest management, non-native tree species, Alpine Space, biosecurity, green infrastructure
Objavljeno v DiRROS: 19.01.2024; Ogledov: 288; Prenosov: 155
Celotno besedilo (1,98 MB)
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Povzetek: In the last decade, stereotactic radiosurgery (SRS) with linear accelerator (linac) has become an important irradiation technique for a variety of malignant and benign intracranial lesions. Although there exist some other radiosurgery techniques, linac based SRS meets the requirements needed for SRSwith low cost modifications. On of the most important additional parts of the equipment is tertiary collimator system which can be attached onto the linac head. We designed and built such system that can be easily fixed onto linac PHILIPS SL - 75/5 with 5 MV photon energy. In our department, we alreadyuse this linac for conventional radiation therapy. Our tertiary collimator system meets all the requirements important for this special modality of radiation therapy. It allows fine centering of the system and has ten various collimators with divergent circular openings having a nominal field diameter ranging from 1.0 cm to 4.0 cm at the isocenter. The accuracy ofthe system was checked by exposing x - ray films at various gantry positions, and recording misalignment of the beams. The width of penumbra was determined using two different dosimetry techniques (film dosimetry and diode measurements).
Objavljeno v DiRROS: 19.01.2024; Ogledov: 217; Prenosov: 53
Celotno besedilo (1,30 MB)