71. Unpublished Mediterranean and Black Sea records of marine alien, cryptogenic, and neonative speciesMichail Ragkousis, Argyro Zenetos, Jamila Ben Souissi, Razy Hoffman, Raouia Ghanem, Ana Fortič, Domen Trkov, Lovrenc Lipej, Borut Mavrič, Martina Orlando-Bonaca, Leon Lojze Zamuda, 2023, drugi znanstveni članki Povzetek: To enrich spatio-temporal information on the distribution of alien, cryptogenic, and neonative species in the Mediterranean and the Black Sea, a collective effort by 173 marine scientists was made to provide unpublished records and make them open access to the scientific community. Through this effort, we collected and harmonized a dataset of 12,649 records. It includes 247 taxa, of which 217 are Animalia, 25 Plantae and 5 Chromista, from 23 countries surrounding the Mediterranean and the Black Sea. Chordata was the most abundant taxonomic group, followed by Arthropoda, Mollusca, and Annelida. In terms of species records, Siganus luridus, Siganus rivulatus, Saurida lessepsianus, Pterois miles, Upeneus moluccensis, Charybdis (Archias) longicollis, and Caulerpa cylindracea were the most numerous. The temporal distribution of the records ranges from 1973 to 2022, with 44% of the records in 2020–2021. Lethrinus borbonicus is reported for the first time in the Mediterranean Sea, while Pomatoschistus quagga, Caulerpa cylindracea, Grateloupia turuturu, and Misophria pallida are first records for the Black Sea; Kapraunia schneideri is recorded for the second time in the Mediterranean and for the first time in Israel; Prionospio depauperata and Pseudonereis anomala are reported for the first time from the Sea of Marmara. Many first country records are also included, namely: Amathia verticillata (Montenegro), Ampithoe valida (Italy), Antithamnion amphigeneum (Greece), Clavelina oblonga (Tunisia and Slovenia), Dendostrea cf. folium (Syria), Epinephelus fasciatus (Tunisia), Ganonema farinosum (Montenegro), Macrorhynchia philippina (Tunisia), Marenzelleria neglecta (Romania), Paratapes textilis (Tunisia), and Botrylloides diegensis (Tunisia). Ključne besede: non-native species, non-indigenous, distribution, invasive alien species, geo-referenced records, Mediterranean Sea, Black Sea Objavljeno v DiRROS: 06.08.2024; Ogledov: 139; Prenosov: 428
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72. Titanium dioxide in our everyday life : is it safe?Matej Skočaj, Metka Filipič, Jana Nunić, Saša Novak, 2011, pregledni znanstveni članek Povzetek: Background. Titanium dioxide (TiO2) is considered as an inert and safe material and has been used in many applications for decades. However, with the development of nanotechnologies TiO2 nanoparticles, with numerous novel and useful properties, are increasingly manufactured and used. Therefore increased human and environmental exposure can be expected, which has put TiO2 nanoparticles under toxicological scrutiny. Mechanistic toxicological studies show that TiO2 nanoparticles predominantly cause adverse effects via induction of oxidative stress resulting in cell damage, genotoxicity, inflammation, immune response etc. The extent and type of damage strongly depends on physical and chemical characteristics of TiO2 nanoparticles, which govern their bioavailability and reactivity. Based on the experimental evidence from animal inhalation studies TiO2 nanoparticles are classified as "possible carcinogenic to humans" by the International Agency for Research on Cancer and as occupational carcinogen by the National Institute for Occupational Safety and Health. The studies on dermal exposure to TiO2 nanoparticles, which is in humans substantial through the use of sunscreens, generally indicate negligible transdermal penetration; however data are needed on long-term exposure and potential adverse effects of photo-oxidation products. Although TiO2 is permitted as an additive (E171) in food and pharmaceutical products we do not have reliable data on its absorption, distribution, excretion and toxicity on oral exposure. TiO2 may also enter environment, and while it exerts low acute toxicity to aquatic organisms, upon long-term exposure it induces a range of sub-lethal effects.
Conclusions. Until relevant toxicological and human exposure data that would enable reliable risk assessment are obtained, TiO2 nanoparticles should be used with great care. Objavljeno v DiRROS: 06.08.2024; Ogledov: 123; Prenosov: 83
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73. A preliminary overview of raptor monitoring in Slovenia : an overview of methodologies, current monitoring status and future perspectivesAl Vrezec, 2012, pregledni znanstveni članek Povzetek: Among 48 raptor species (birds of prey, owls, shrikes) recorded recently in Slovenia, some long-term monitoring activities are being conducted for more than half of them, mainly for conservation and research purposes. However, national coverage is achieved only in 15% of the species, whereas other monitoring programmes are more or less local. Two monitoring approaches are considered, the species specific approach and assemblage approach. Current ongoing monitoring programmes for raptors in Slovenia lack monitoring of breeding success, which is now confined to only a few owl species. Use of nestboxes should therefore be considered more broadly in the future for some species at least. Ključne besede: Slovenia, raptor monitoring, birds of prey, owls, shrikes, monitoring methodology Objavljeno v DiRROS: 06.08.2024; Ogledov: 136; Prenosov: 72
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74. Overview of raptor monitoring activities in EuropeAl Vrezec, Guy Duke, András Kovács, Pertti Saurola, Chris Wernham, Ian Burfield, Paola Movalli, Irena Bertoncelj, 2012, pregledni znanstveni članek Povzetek: Despite the key role of raptors (including birds of prey Falconiformes and owls Strigiformes) in ecosystems and their sensitivity to environmental change, a well coordinated, Europe-wide monitoring of raptors is lacking. EURAPMON, a Research Networking Programme of the European Science Foundation, was launched with the aim of establishing a sustainable Europewide network for monitoring of raptors. An overview of current monitoring schemes for raptor populations in 28 European countries, as reported by EURAPMON National Coordinators at the workshop in Murcia (Spain) in 2012, showed existing monitoring schemes to be limited to a restricted number of species (mostly diurnal and rare raptor species). The most widely monitored species are the Golden Eagle Aquila chrysaetos amongst diurnal raptors and the Eagle Owl Bubo bubo amongst owls. Broad coverage of a species range across Europe is reached only for restricted-range species. The key driver for monitoring, which is mostly coordinated by NGOs, is conservation, and the main end users are governmental institutions. International collaboration in the field of monitoring of raptors is mainly regional and not yet pan-European in scale. The involvement of volunteers in raptor monitoring was perceived as the main strength of many schemes, but insufficient manpower and a focus on rare species were recognised as the main weaknesses across Europe as a whole. Among priorities identified for the future development of monitoring schemes are: improvements to national coordination; support to increase the number of volunteers; and assurances of stable funding. Further analysis of EURAPMON questionnaires will identify knowledge gaps, which will steer good practice guidance on survey methodologies; the need for the latter was identified as the main benefit that National Coordinators expect to gain from international networking Ključne besede: Europe, raptor monitoring scheme, birds of prey, owls, monitoring inventory Objavljeno v DiRROS: 06.08.2024; Ogledov: 142; Prenosov: 89
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75. Nanoparticles for hyperthermic therapy : synthesis strategies and applications in glioblastomaJyoti Verma, Sumit Lal, Cornelis J. F. van Noorden, 2014, pregledni znanstveni članek Povzetek: Glioblastoma multiforme (GBM) is the most common and most aggressive malignant primary brain tumor in humans. Current GBM treatment includes surgery, radiation therapy, and chemotherapy, sometimes supplemented with novel therapies. Despite recent advances, survival of GBM patients remains poor. Major challenges in GBM treatment are drug delivery across the blood–brain barrier, restriction of damage to healthy brain tissues, and limitation of resistance to therapies. This article reviews recent advances in the application of magnetic nanoparticles (MNPs), gold nanorods (GNRs), and carbon nanotubes (CNTs) for hyperthermia ablation of GBM. First, the article introduces GBM, its current treatment, and hyperthermia as a potential modality for the management of GBM. Second, it introduces MNPs, GNRs, and CNTs as inorganic agents to induce hyperthermia in GBM. Third, it discusses different methodologies for synthesis of each inorganic agent. Finally, it reviews in vitro and in vivo studies in which MNPs, GNRs, and CNTs have been applied for hyperthermia ablation and drug delivery in GBM. Ključne besede: hyperthermia, targeted drug delivery, SPIONs, gold nanorods, carbon nanotubes Objavljeno v DiRROS: 06.08.2024; Ogledov: 106; Prenosov: 110
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76. Manipulating behaviour with substrate-borne vibrations - potential for insect pest controlJernej Polajnar, Anna Eriksson, Andrea Lucchi, Gianfranco Anfora, Meta Virant-Doberlet, Valerio Mazzoni, 2015, pregledni znanstveni članek Povzetek: This review presents an overview of the potential use of substrate-borne vibrations for the purpose of achieving insect pest control in the context of integrated pest management. Although the importance of mechanical vibrations in the life of insects has been fairly well established, the effect of substrate-borne vibrations has historically been understudied, in contrast to sound sensu stricto. Consequently, the idea of using substrate-borne vibrations for pest control is still in its infancy. This review therefore focuses on the theoretical background, using it to highlight potential applications in a field environment, and lists the few preliminary studies that have been or are being performed. Conceptual similarities to the use of sound, as well as limitations inherent in this approach, are also noted. © 2014 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry. Ključne besede: insects, behaviour, pest control, substrate-borne vibrations Objavljeno v DiRROS: 06.08.2024; Ogledov: 127; Prenosov: 107
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77. Using multi-tracer inference to move beyond single-catchment ecohydrology : invited reviewBenjamin W. Abbott, Viktor Baranov, Clara Mendoza-Lera, Mukundh Narayanan Balasubramanian, José Gonçalves, Stefan Krause, 2016, pregledni znanstveni članek Povzetek: Protecting or restoring aquatic ecosystems in the face of growing anthropogenic pressures requires an understanding of hydrological and biogeochemical functioning across multiple spatial and temporal scales. Recent technological and methodological advances have vastly increased the number and diversity of hydrological, biogeochemical, and ecological tracers available, providing potentially powerful tools to improve understanding of fundamental problems in ecohydrology, notably: 1. Identifying spatially explicit flowpaths, 2. Quantifying water residence time, and 3. Quantifying and localizing biogeochemical transformation. In this review, we synthesize the history of hydrological and biogeochemical theory, summarize modern tracer methods, and discuss how improved understanding of flowpath, residence time, and biogeochemical transformation can help ecohydrology move beyond description of site-specific heterogeneity. We focus on using multiple tracers with contrasting characteristics (crossing proxies) to infer ecosystem functioning across multiple scales. Specifically, we present how crossed proxies could test recent ecohydrological theory, combining the concepts of hotspots and hot moments with the Damköhler number in what we call the HotDam framework. Ključne besede: hydrological tracer, environmental hydrology, ecohydrology, aquatic ecology Objavljeno v DiRROS: 06.08.2024; Ogledov: 132; Prenosov: 175
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78. Application of whole genome shotgun sequencing for detection and characterization of genetically modified organisms and derived productsArne Holst-Jensen, Bjørn Spilsberg, Alfred J. Arulandhu, Esther Kok, Jianxin Shi, Jana Žel, 2016, pregledni znanstveni članek Povzetek: The emergence of high-throughput, massive or next-generation sequencing technologies has created a completely new foundation for molecular analyses. Various selective enrichment processes are commonly applied to facilitate detection of predefined (known) targets. Such approaches, however, inevitably introduce a bias and are prone to miss unknown targets. Here we review the application of high-throughput sequencing technologies and the preparation of fit-for-purpose whole genome shotgun sequencing libraries for the detection and characterization of genetically modified and derived products. The potential impact of these new sequencing technologies for the characterization, breeding selection, risk assessment, and traceability of genetically modified organisms and genetically modified products is yet to be fully acknowledged. The published literature is reviewed, and the prospects for future developments and use of the new sequencing technologies for these purposes are discussed. Ključne besede: cisgene, intragene, traceability, traceability, transcriptome sequencing, transgene, unknown GMO Objavljeno v DiRROS: 06.08.2024; Ogledov: 130; Prenosov: 88
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79. Novel therapeutic strategies to target leukemic cells that hijack compartmentalized continuous hematopoietic stem cell nichesVashendriya V. V. Hira, Cornelis J. F. van Noorden, Hetty E. Carraway, Jaroslaw P. Maciejewski, Remco J. Molenaar, 2017, pregledni znanstveni članek Povzetek: Acute myeloid leukemia and acute lymphoblastic leukemia cells hijack hematopoietic stem cell (HSC) niches in the bone marrow and become leukemic stem cells (LSCs) at the expense of normal HSCs. LSCs are quiescent and resistant to chemotherapy and can cause relapse of the disease. HSCs in niches are needed to generate blood cell precursors that are committed to unilineage differentiation and eventually production of mature blood cells, including red blood cells, megakaryocytes, myeloid cells and lymphocytes. Thus far, three types of HSC niches are recognized: endosteal, reticular and perivascular niches. However, we argue here that there is only one type of HSC niche, which consists of a periarteriolar compartment and a perisinusoidal compartment. In the periarteriolar compartment, hypoxia and low levels of reactive oxygen species preserve the HSC pool. In the perisinusoidal compartment, hypoxia in combination with higher levels of reactive oxygen species enables proliferation of progenitor cells and their mobilization into the circulation. Because HSC niches offer protection to LSCs against chemotherapy, we review novel therapeutic strategies to inhibit homing of LSCs in niches for the prevention of dedifferentiation of leukemic cells into LSCs and to stimulate migration of leukemic cells out of niches. These strategies enhance differentiation and proliferation and thus sensitize leukemic cells to chemotherapy. Finally, we list clinical trials of therapies that tackle LSCs in HSC niches to circumvent their protection against chemotherapy. Ključne besede: hematopoietic stem cell niche, hijacking, leukemic stem cells, bone marrow, therapy resistance, leukemia Objavljeno v DiRROS: 06.08.2024; Ogledov: 127; Prenosov: 149
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80. Proteases and cytokines as mediators of interactions between cancer and stromal cells in tumoursBarbara Breznik, Helena Motaln, Tamara Lah Turnšek, 2017, pregledni znanstveni članek Povzetek: Proteolytic enzymes are highly relevant in different processes of cancer progression. Their interplay with other signalling molecules such as cytokines represents important regulation of multicellular cross-talk. In this review, we discuss protease regulation mechanisms of cytokine signalling in various types of cancer. Additionally, we highlight the reverse whereby cytokines have an impact on protease expression in an autocrine and paracrine manner, representing complex feedback mechanisms among multiple members of these two protein families. The relevance of the protease-cytokine axis is illustrated in glioblastoma, where interactions between normal mesenchymal stem cells and cancer cells play an important role in this very malignant form of brain cancer. Ključne besede: cellular cross-talk, glioblastoma, invasion, mesenchymal stem cells, protease-cytokine signalling Objavljeno v DiRROS: 06.08.2024; Ogledov: 133; Prenosov: 82
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