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Povzetek: In our previous study, vinblastine (VLB) was shown to increase the plasma membrane fluidity. This effect of VLB might be exploited for better transport of drugs through the plasma membrane. The aim of the present study was to determine whether pretreatment with VLB can increase the cytotoxic effect of BLM on intraperitoneal SA-1 tumors in mice. Materials and methods. BLM and VLBwere used as single agents or in various combinations, i.e. BLM injected 24h before VLB or vice-versa, VLB injected 24 h before BLM. Cell and animal survival together with DNA histograms were the end-points used to determine the effect of these combined treatments. Results. Both drugs, either as singletreatment or in different combined therapy schedules reduced significantly the number of cells in peritoneal lavage, compared to control, saline treated animals. The combination of VLB, followed by BLM after 24 h reduced significantly the number of cells in peritoneal lavage, compared to the treatment in which BLM was followed by VLB or to the treatment with singledrugs alone. Median survival time of mice treated with VLB alone, BLM alone and combination of both drugs was significantly prolonged compared to the control untreated mice. When VLB and BLM were combined, both treatment combinations were more effective than monochemotherapies with VLB or BLM. The best results were obtained when VLB was followed by BLM after 24 h. The DNA histogram of cells treated with VLB showed a decreased number of cells in S phase and an increased number of cells with DNA values greater than in G2M compartment compared to the control untreated cells. BLM in the dosage used inthese experiments did not affect the progression of cells through cell cycle. Both combinations of VLB and BLM produced similar cell kinetic effect as VLB alone. Conclusion. (Abstract truncated at 2000 characters.)
Objavljeno v DiRROS: 23.01.2024; Ogledov: 253; Prenosov: 51
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Povzetek: Background. Tunga penetrans is a burrowing flea that is prevalent in Central and South America, the Caribbean, tropical Africa, India and Pakistan. Tungiasis results from cutaneous infestation by gravid female flea, Tunga penetrans. Case report. We report a case of tungiasis in a male who had been on a tourist expedition to Bolivia and Peru. The condition had manifested as aparaungual infiltration of a toe, that was clinically suspicious for tumor. Conclusions. Microscopic examination of the lesion and travel history led to the diagnosis of tungiasis. This is the first case report of Tunga penetrans infestation in Slovenia.
Objavljeno v DiRROS: 23.01.2024; Ogledov: 232; Prenosov: 55
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Povzetek: Background. Interstitial fluid pressure (IFP) has been recognised as the most important obstacle in macromolecular drug delivery to solid tumors. Our interest was to reduce differentialy tumor IFP with respect to IFP in surrounding and normal tissues in order to increase drug delivery to tumors aswell to increase tumor blood flow and potentialy tumor tissue oxygenation. In this preliminary study we used hydralazine, a longacting arterial vasodilator. Materials and methods. Measurements of interstitial fluid pressure were performed in vivo on CBA mice bearing SAF tumors using wick-in-needle technigue. Altogether eleven measurements were obtained on different animals with tumors of different size. Results. IFP in tumors after hydralazine administration was significantly lower than initial values in corresponding tumors. On average tumor IFP decreased for 33 % from initial value. On the contrary, no change in IFP in normal tissue was observed after hydralazine administration. Also, after injection of physiological saline instead of hydralazine there was no change in IFP neither in tumors nor in muscle. The results of our preliminary study on the effect of hydralazine on IFP in SAF tumor model is in accordance to previously reported studies. The decrease in tumor IFP was only observed in tumors, but not in muscle and surrounding subcutis. Conclusion. Hydralazine is a vasodilator which is capable of decreasing tumor IFP, reproducibly and with favorably long lasting dynamics.
Ključne besede: sarcoma, experimental drug therapy, hydralazine, extracellular space, interstitial fluid pressure, manometry
Objavljeno v DiRROS: 23.01.2024; Ogledov: 272; Prenosov: 67
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Ključne besede: aging, sensory performance, motor performance, cognitive performance, multisensory integration
Objavljeno v DiRROS: 22.01.2024; Ogledov: 291; Prenosov: 111
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Povzetek: Within previous investigation alkali activation of waste casting cores at room temperature did not give promising results, i.e. when the precursor was gently ground and sieved below 600 %m the alkali activated material fell apart at demolding, and when the precursor was ground below 90 %m, the alkali activated material did not solidify in more than 2 years. , Therefore different drying/curing methods were applied to enhance the reaction. Waste casting cores were prepared in two granulations (sieved below 600 %m and below 90 %m), activated with Na -water glass and 10 M NaOH, cured at different temperatures (70 °C and room temperature), and subsequently cured/dried at three different conditions: room temperature, 110 °C, and irradiated with microwaves. The highest compressive strength, 25 MPa, was gained with subsequent curing/drying at 110 °C. The lowest density, 0.5 kg/l, with compressive strength above 3 MPa, was achieved with subsequent curing/drying with microwaves .
Ključne besede: waste casting cores, alkali activation, curing, drying, microwaves, mechanical strength
Objavljeno v DiRROS: 22.01.2024; Ogledov: 284; Prenosov: 149
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