1301. The urokinase-type plasminogen activator, its inhibitors and its receptor - the new prognostic factors in solid cancersSimona Borštnar, Tanja Čufer, Zvonimir Rudolf, 1997, pregledni znanstveni članek Povzetek: The urokinase-type plasminogen activator (uPA), its inhibitors (PAI-1 and PAI-2) and its receptor (uPAR) play nan important role in the degradation of the intercellular tissue, the process which affects the ability of cancer cells to invade to surrounding tissue and to metastasize. The results of clinical studies performed in the past few years point out a significant influence of uPA, PAI-1, PAI-2 and uPAR on the course of the disease and survival of patients with solid tumours, particularly breast cancer. Hopefullythe categorization of patients according to the content of the serineproteases and its inhibitors in tumour tissues could provide a basis formore rational treatment planning and thus improving patients' survival.
Objavljeno v DiRROS: 18.01.2024; Ogledov: 278; Prenosov: 84
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1307. Conservative treatment in head and neck cancerMiha Žargi, 1997, pregledni znanstveni članek Povzetek: The incidence of head and neck cancer in Slovenia is increasing, especially inmale population. Late diagnosis, in advanced of disease, influences not onlythe treatment results but also the treatment strategies and modalities: aggressive surgery combined with radiotherapy and reconstructive procedures and chemotherapy in inoperable tumors is therefore indicated too frequently instead of organ sparing treatment. Early detection should be improved, especially in the target population, and all up-to-date diagnostic technology should be employed in centralized multidisciplinary pre-treatment assessment. Good co-operation between surgeons, radio and chemotherapists in planning, performing as well as in evaluating the treatment is also a basic condition for better implementation of organ sparing approaches in head and neck cancer.
Objavljeno v DiRROS: 17.01.2024; Ogledov: 317; Prenosov: 70
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1310. Voice quality after radiation therapy of early glottic cancerIrena Hočevar-Boltežar, Miha Žargi, 1997, izvirni znanstveni članek Povzetek: Radiation therapy is generally accepted as a successful treatment modality forearly glottic cancer offering an acceptable voice quality after the treatment. In order to evaluate objectively the voice quality in irradiated patients and to eliminate the influence of decreasing voice quality as a result of normal aging, the results of the acoustic analysis of voice in 20 patients with early glottic cancer treated with radiation therapy were compared to the results of 20 age-matched volunteers. The results established worse voice quality in the irradiated group but the difference was not significant except in amplitude perturbation quotient which expresses the instability of loudness. In order to identity the factors which could influence the quality of voice after irradiation of the laryngeal carcinoma, the results of laryngoscopy and the biopsy extension, were correlated with theresults of the perceptive voice evaluation and the results of acoustic voice analysis. No significant influence of the stated factors on the voice quality of the patients was established. Only the irregular glottic gap duringphonation indicated to be connected with very hoarse voice. In conclusion, radiation therapy of early glottic cancer results in an abnormal, but still satisfactory voice quality when compared to the voice quality of normal age-matched speakers. The hoarseness is the results of instability of pitch and specifically the instability of amplitude (loudness). The voice quality after the treatment can be influenced by the tumor extension and localization, the sequels of excisional biopsy, and the radiation therapy or functional disorder. All the stated factors are very intermingled and are probably acting together.
Objavljeno v DiRROS: 16.01.2024; Ogledov: 336; Prenosov: 71
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