151. Glyoxal as single crosslinker for mechanically blown, condensed and hydrolyzable tannin foamsJonas Eckardt, Michele De Nato, Elena Colusso, Lorenzo Moro, Primož Šket, Samuele Giovando, Gianluca Tondi, 2025, izvirni znanstveni članek Objavljeno v DiRROS: 05.12.2025; Ogledov: 70; Prenosov: 47
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155. Comparison of vaginal prostaglandin E2 delivery system versus expectant management in term premature rupture of membranes : a andomized controlled trialBlaž Pavič, Polona Pečlin, 2025, izvirni znanstveni članek Povzetek: Background: Premature rupture of the membranes (PROM) occurring after the 37th week of gestation, prior to the onset of regular contractions, affects approximately 8% of pregnancies and typically leads to the spontaneous onset of labor. A prolonged interval between PROM and delivery increases the risk of maternal infection and early neonatal sepsis. This prospective, randomized study aimed to assess the efficacy, safety, and maternal satisfaction associated with the use of a vaginal prostaglandin E2 (PGE2) delivery system compared to expectant management approach following PROM. Methods: Term pregnant women with a singleton cephalic presentation, who experienced PROM within 4–12 hours and had an unripe cervix, were randomized into 2 groups. The intervention group received labor induction using a slow-release 10 mg dinoprostone (PGE2) vaginal delivery system, whereas the control group underwent expectant management. If active labor had not commenced within 24 hours of enrollment, labor was induced with oxytocin in both groups. Results: In this prospective randomized study, 74 pregnant women with PROM after the 37th week of gestation, prior to before the onset of active labor, were enrolled. Active labor began within 24 hours after enrollment in 54% of the control group and 77% of the intervention group (p = 0.036). The intervention group had a 3.42-hour shorter interval from randomization to delivery; however, this difference was not statistically significant (p = 0.067). When analyzing time to spontaneous vaginal delivery, administration of PGE2 in the intervention group was associated with a 4.3-hour reduction in delivery time (p = 0.029). There was no statistically significant difference regarding mode of delivery between the groups, with 6% of cesarean section in the intervention group vs. 15% in the control group (p = 0.343). No significant differences were observed between the groups in oxytocin use, labor complication rates, neonatal outcomes, or participant satisfaction. Notably, in a significant proportion of participants (37%) in the intervention group, the vaginal PGE2 delivery system was unintentionally expelled prior to the onset of active labor. Conclusion:The slow-release PGE2 vaginal system reduced the time from randomization to the onset of active labor and to vaginal delivery in pregnant women after PROM, without impacting the mode of delivery maternal and neonatal complications rates, or satisfaction rate compared to expectant management approach. Early induction of labor following PROM with a PGE2 vaginal system represents an effective and safe alternative to expectant labor management.
Ključne besede: premature rupture of membranes, PROM, induction of labor, prostaglandin E2 vaginal system, dinoprostone
Objavljeno v DiRROS: 04.12.2025; Ogledov: 127; Prenosov: 51
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156. Predictors of loneliness in Parkinson's disease and craniocervical dystoniaSuzette Shahmoon, Dejan Georgiev, Paul Jarman, Kailash P. Bhatia, Patricia Limousin, Marjan Jahanshahi, 2025, izvirni znanstveni članek Povzetek: Background Loneliness is a state in which an individual feels socially isolated due to deficiencies in the quantity or quality of social relationships and interaction. To date very little is known about loneliness in Parkinson's disease (PD) and focal/segmental craniocervical dystonia (FSCD). Objectives To explore whether level of loneliness is disease-specific by comparing PD, FCSD and healthy controls (HCs), and to define predictors of loneliness in both PD and FSCD. Methods Eighty-two people with PD, 63 people with FSCD and 50 HC were surveyed. The UCLA Loneliness Scale was used to assess loneliness. Various non-motor symptoms, psychosocial variables and measures of subjective well-being were assessed and used as potential predictors of loneliness. Results There was no significant difference in reported levels of loneliness between people with PD and matched HCs, and between people with PD and people with FSCD, but people with FSCD reported higher levels of loneliness than HCs (p = 0.018). Perceived stigma predicted loneliness in both disease groups (p < 0.001). Additionally, non-motor symptoms (p = 0.006), lack of optimism (p = 0.015) and practical social support (p = 0.006) predicted loneliness in people with PD. Patients with PD and FSCD with higher perceived stigma levels felt lonelier (p < 0.001), as did female patients with PD (p = 0.004), younger patients with FSCD (p = 0.007) and older patients with PD (p = 0.023). Conclusions We identified important predictors of loneliness in PD and FSCD. The identified age- and gender-specific differences in loneliness in people with PD and FSCD contribute to our better understanding of this complex and not yet fully understood concept.
Ključne besede: loneliness, Parkinson's disease, focal/segmental craniocervical dystonia, optimism and stigma
Objavljeno v DiRROS: 04.12.2025; Ogledov: 107; Prenosov: 38
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158. Proportion of confirmed Lyme neuroborreliosis cases among adult patients with suspected early European Lyme neuroborreliosisKatarina Ogrinc, Petra Bogovič, Tereza Rojko, Vera Maraspin-Čarman, Eva Ružić-Sabljić, Andrej Kastrin, Klemen Strle, Gary P. Wormser, Franc Strle, 2025, izvirni znanstveni članek Povzetek: Purpose To determine the frequency of confirmed Lyme neuroborreliosis (LNB) cases in adult patients with three different clinical presentations consistent with early LNB. Methods Data were obtained through routine health care at the UMC Ljubljana, Slovenia from 2005 to 2022, using clinical pathways. The patients were classified into three groups: (i) radicular pain of new onset (N=332); or (ii) involvement of cranial nerve(s) but without radicular pain (N=997); or (iii) erythema migrans (EM) skin lesion(s) in conjunction with symptoms suggestive of nervous system involvement but without either cranial nerve palsy or radicular pain (N=240). The diagnosis of LNB considered the following variables: the presence of: (1) neurologic symptoms consistent with LNB (with no other obvious explanation); (2) cerebrospinal fluid (CSF) pleocytosis (>5×▫$10^$▫ leukocytes/L); and (3) demonstration of intrathecal synthesis of borrelial antibodies, and/or cultivation of borrelia from CSF, and/or the presence of EM. Patients fulfilling only the first two criteria were interpreted as having possible LNB, while those who satisfied all three criteria were regarded as having confirmed LNB. Results Of 1569 adult patients, 348 (22.2%) had confirmed LNB and 70 (4.5%) others had possible LNB. The proportion of confirmed LNB cases was the highest for patients with radicular pain (217/332, 65.4%), followed by the group with EM and neurologic symptoms (47/240, 19.6%), and those with cranial neuritis (84/997, 8.4%). Conclusion Only 22% of patients evaluated had confirmed LNB. The proportion of confirmed LNB cases correlated with clinical presentation and was highest among patients with recent onset of radicular pain.
Ključne besede: Lyme borreliosis, Lyme neuroborreliosis, criteria, cerebrospinal fluid, Bannwarth syndrome, cranial neuritis, borrelial meningitis, intrathecal borrelial antibody synthesis, Borrelia culture
Objavljeno v DiRROS: 04.12.2025; Ogledov: 111; Prenosov: 62
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159. Ours, yours, theirs, no one’s? The heritage of multicultural areasAnja Moric, Marjeta Pisk, 2025, drugi znanstveni članki Ključne besede: heritage, heritagisation, multicultural areas, marginalised spaces, performativity of heritage, heritage negotiations
Objavljeno v DiRROS: 04.12.2025; Ogledov: 95; Prenosov: 43
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160. Lower frequency of multiple erythema migrans skin lesions in Lyme reinfections, EuropeFranc Strle, Vera Maraspin-Čarman, Stanka Lotrič-Furlan, Katarina Ogrinc, Tereza Rojko, Andrej Kastrin, Klemen Strle, Gary P. Wormser, Petra Bogovič, 2025, izvirni znanstveni članek Povzetek: The erythema migrans (EM) skin lesion is the most common clinical manifestation of Lyme borreliosis. Information about EM in Lyme borreliosis reinfection is limited. Of the 12,384 cases with diagnosed EM at an outpatient clinic during 1990–2014 in Slovenia, 1,962 (15.8%) cases occurred in patients who were treated previously for Lyme borreliosis, including 1,849 (94.2%) who had previously had EM. The percentage of reinfected patients who sought care with disseminated Lyme borreliosis at the time of reinfection, as manifested by multiple EM skin lesions, was significantly lower than for EM patients with no history of Lyme borreliosis (5.5% [108/1,962] vs. 7.4% [769/10,427]; p = 0.002). None of the clinical manifestations of Lyme borreliosis in Europe will completely protect against EM developing in patients in the future. The reoccurrence of Lyme borreliosis manifested by multiple EM lesions is significantly less likely than for patients with no history of Lyme borreliosis.
Ključne besede: Lyme borreliosis, reinfection, erythema migrans
Objavljeno v DiRROS: 04.12.2025; Ogledov: 123; Prenosov: 49
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