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Ključne besede: identical location electron microscopy, image analysis, machine learning, electrocatalysis, metallic nanoparticles
Objavljeno v DiRROS: 01.07.2022; Ogledov: 789; Prenosov: 526
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Povzetek: Despite widely and regularly used therapy asthma in children is not fully controlled. Recognizing the complexity of asthma phenotypes and endotypes imposed the concept of precision medicine in asthma treatment. By applying machine learning algorithms assessed with respect to their accuracy in predicting treatment outcome, we have successfully identified 4 distinct clusters in a pediatric asthma cohort with specific treatment outcome patterns according to changes in lung function (FEV1 and MEF50), airway inflammation (FENO) and disease control likely affected by discrete phenotypes at initial disease presentation, differing in the type and level of inflammation, age of onset, comorbidities, certain genetic and other physiologic traits. The smallest and the largest of the 4 clusters- 1 (N = 58) and 3 (N = 138) had better treatment outcomes compared to clusters 2 and 4 and were characterized by more prominent atopic markers and a predominant allelic (A allele) effect for rs37973 in the GLCCI1 gene previously associated with positive treatment outcomes in asthmatics. These patients also had a relatively later onset of disease (6 + yrs). Clusters 2 (N = 87) and 4 (N = 64) had poorer treatment success, but varied in the type of inflammation (predominantly neutrophilic for cluster 4 and likely mixed-type for cluster 2), comorbidities (obesity for cluster 2), level of systemic inflammation (highest hsCRP for cluster 2) and platelet count (lowest for cluster 4). The results of this study emphasize the issues in asthma management due to the overgeneralized approach to the disease, not taking into account specific disease phenotypes.
Ključne besede: asthma, allergy and immunology, pediatrics, machine learning, treatment outcome, phenotypes, childhood asthma, clustering
Objavljeno v DiRROS: 16.08.2021; Ogledov: 1123; Prenosov: 769
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Povzetek: Forecasting the residential natural gas demand for large groups of buildings is extremely important for efficient logistics in the energy sector. In this paper different forecast models for residential natural gas demand of an urban area were implemented and compared. The models forecast gas demand with hourly resolution up to 60 h into the future. The model forecasts are based on past temperatures, forecasted temperatures and time variables, which include markers for holidays and other occasional events. The models were trained and tested on gas-consumption data gathered in the city of Ljubljana, Slovenia. Machine-learning models were considered, such as linear regression, kernel machine and artificial neural network. Additionally, empirical models were developed based on data analysis. Two most accurate models were found to be recurrent neural network and linear regression model. In realistic setting such trained models can be used in conjunction with a weather-forecasting service to generate forecasts for future gas demand.
Ključne besede: demand forecasting, buildings, energy modeling, forecast accuracy, machine learning
Objavljeno v DiRROS: 15.03.2019; Ogledov: 2479; Prenosov: 1143
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