1251. Interferon alpha (IFN-[alpha]) in treatment of malignant diseasesBerta Jereb, 1997, pregledni znanstveni članek Povzetek: There are several natural varieties of IFN-alpha in clinical use. Although IFNs were the first cytokines in use as a new treatment modality, we still know little about their mode of action in malignancies. IFN-alpha can inhibit cell growth, but it has been shown only recently, on malignant cells from patients with multiple myeloma, that IFN-alpha can exert a direct cytotoxic effect on tumor cells. The treatment with natural leucocyte IFN-alpha in dosesused in the early clinical trials, are still most widely used. It has been shown that through a high local concentration by local application in malignant melanoma, basalioma, pleural carcinosis, glioblastoma, total local tumor control may be achieved. it is thys not known what the optimal doses of IFN-alpha are, and they may vary by the tumor type, as well as from patient topatient. The neccessary duration of treatment also remains an open question.IFNs are a tool for treatment of malignant tumors. Their cytotoxic effect, however, is not strong enough and does not last. At present, there is a vast field of investigative work stil open-but in the meantime it seems necessary to proceed with clinical trials of different types of IFN, the natural IFN-alpha again beeing the most interesting one.
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1253. Diagnostic value of planar myocardial perfusion scintigraphy in patients with coronary artery diseaseMarko Klančič, Metka Milčinski, Darko Zorman, 1997, izvirni znanstveni članek Povzetek: Patients with suspected or proven coronary artery disease are investigated using noninvasive and invasive diagnostic methods. Noninvasive myocardial perfusion scintigraphy provides data on myocardial perfusion during stress andat rest. Coronary angiography is invasive morphologic method, performed before coronary artery dilatation or surgery. Aim of our retrograde analysis of planar thallium myocardial perfusion scintigrams and coronary angiograms was to assess sensitivity and specificity of rnyocardial perfusion planar scanning and to evaluate causes of possible disagreement. Original readings ofmyocardial perfusion scans and coronary angiograms of 156 patients with coronary artery disease were compared. When results of both investigations were partially concordant or discordant, the original studies were reviewed. Concordant results of both examinations were found in 62% of patients. In only3% (5 patierrts) the results were discordant and the reason for disagreement of results of both studies could not be detected. Most of the remaining 55 patients had more pronounced myocardial perfusion defects than was the estinrated severity of cororsary artery stenosis, attributed to the different nature of both irtvestigations. Anonralous coronary artery was foundirt 3% of all patients, tortuous coronary arteries with slow ftow of coritrast media in 9 patients (6% of all) and arterial hypertension with extreme left ventricular wall hypertrophy in one patient. Serrsitivity of the rnyocardial perfusion scintigraphy was l00% and specificity 50%. Positive predictive valrre for coronary artery disease was 96% and negative predictive value was 100 %. We cconclude that myocardial perfusion scintigraphy has a definite role in: diagnosis and follow-up of patients with suspected or provencoronary artery disease. (Abstracts truncated at 2000 characters)
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1254. The urokinase-type plasminogen activator, its inhibitors and its receptor - the new prognostic factors in solid cancersSimona Borštnar, Tanja Čufer, Zvonimir Rudolf, 1997, pregledni znanstveni članek Povzetek: The urokinase-type plasminogen activator (uPA), its inhibitors (PAI-1 and PAI-2) and its receptor (uPAR) play nan important role in the degradation of the intercellular tissue, the process which affects the ability of cancer cells to invade to surrounding tissue and to metastasize. The results of clinical studies performed in the past few years point out a significant influence of uPA, PAI-1, PAI-2 and uPAR on the course of the disease and survival of patients with solid tumours, particularly breast cancer. Hopefullythe categorization of patients according to the content of the serineproteases and its inhibitors in tumour tissues could provide a basis formore rational treatment planning and thus improving patients' survival.
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1260. Conservative treatment in head and neck cancerMiha Žargi, 1997, pregledni znanstveni članek Povzetek: The incidence of head and neck cancer in Slovenia is increasing, especially inmale population. Late diagnosis, in advanced of disease, influences not onlythe treatment results but also the treatment strategies and modalities: aggressive surgery combined with radiotherapy and reconstructive procedures and chemotherapy in inoperable tumors is therefore indicated too frequently instead of organ sparing treatment. Early detection should be improved, especially in the target population, and all up-to-date diagnostic technology should be employed in centralized multidisciplinary pre-treatment assessment. Good co-operation between surgeons, radio and chemotherapists in planning, performing as well as in evaluating the treatment is also a basic condition for better implementation of organ sparing approaches in head and neck cancer.
Objavljeno v DiRROS: 17.01.2024; Ogledov: 286; Prenosov: 64
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