771. A previously unknown path to corpuscularism in the Seventeenth century : Santorio’s Marginalia to the Commentaria in Primam Fen Primi Libri Canonis Avicennae (1625)Fabrizio Bigotti, 2017, izvirni znanstveni članek Povzetek: This paper presents some of Santorio’s marginalia to his Commentaria in primam fen primi libri Canonis Avicennae (Venice, 1625), which I identified in the Sloane Collection of the British Library in 2016, as well as the evidence for their authorship. The name of the Venetian physician Santorio Santori (1561–1636) is linked with the introduction of quantification in medicine and with the invention of precision instruments that, displayed for the first time in this work, laid down the foundations for what we today understand as evidence-based medicine. But Santorio’s monumentale opus also contains evidence of many quantified experiments and displays his ideas on mixtures, structure of matter and corpuscles, which are in many cases clarified and completed by the new marginalia. These ideas testify to an early interest in chemistry within the Medical School of Padua which predates both Galileo and Sennert and which has hitherto been unknown.
Ključne besede: quantification in medicine, marginalia, corpuscular theory, early modern chemistry
Objavljeno v DiRROS: 13.10.2025; Ogledov: 167; Prenosov: 50
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772. Commenting on Aristotle with a knife : the heretical anatomies of Bassanio LandiFabrizio Bigotti, 2023, izvirni znanstveni članek Povzetek: Drawingonavarietyof sources, includingmanuscript notes and awidevarietyof published material, this article offers the first analysis in English of Bassanio Landi’s works in their medical and philosophical context. I argue that while Landi’s output is characteristic of its sixteenth-century Paduan milieu, his approach to methodological questions in anatomy and the arts, as well as his paraphrase of Aristotle’s De anima, make it possible to locate him within the heretical tradition that stretches from Pietro Pomponazzi (1462–1525) to Paolo Sarpi (1552–1623).
Ključne besede: anatomy, heretical thinking, sixteenth-century Padua, Aristotle’s De Anima, Bassanio Landi
Objavljeno v DiRROS: 13.10.2025; Ogledov: 154; Prenosov: 81
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776. Genomic signatures of climate-driven (mal)adaptation in an iconic conifer, the English Yew (Taxus baccata L.)Thomas Francisco, Maria Mayol, Elia Vajana, Miquel Riba, Marjana Westergren, Stephen Cavers, Sara Pinosio, Francesca Bagnoli, Maurizio Marchi, Filipos Aravanopoulos, 2025, izvirni znanstveni članek Povzetek: The risk of climate maladaptation is increasing for numerous species, including trees. Developing robust methods to assess population maladaptation remains a critical challenge. Genomic offset approaches aim to predict climate maladaptation by characterizing the genomic changes required for populations to maintain their fitness under changing climates. In this study, we assessed the risk of climate maladaptation in European populations of English yew (Taxus baccata), a long-lived tree with a patchy distribution across Europe, the Atlas Mountains, and the Near East, where many populations are small or threatened. We found evidence suggesting local climate adaptation by analyzing 8616 SNPs in 475 trees from 29 European T. baccata populations, with climate explaining 18.1% of genetic variance and 100 unlinked climate-associated loci identified via genotype-environment association (GEA). Then, we evaluated the deviation of populations from the overall gene-climate association to assess variability in local adaptation or different adaptation trajectories across populations and found the highest deviations in low latitude populations. Moreover, we predicted genomic offsets and successfully validated these predictions using phenotypic traits assessed in plants from 26 populations grown in a comparative experiment. Finally, we integrated information from current local adaptation, genomic offset, historical genetic differentiation, and effective migration rates to show that Mediterranean and high-elevation T. baccata populations face higher vulnerability to climate change than low-elevation Atlantic and continental populations. Our study demonstrates the practical use of the genomic offset framework in conservation genetics, offers insights for its further development, and highlights the need for a population-centered approach that incorporates additional statistics and data sources to credibly assess climate vulnerability in wild plant populations.
Ključne besede: climate change , genomic offset , genotype- environment association , local adaptation , Taxus baccata
Objavljeno v DiRROS: 10.10.2025; Ogledov: 300; Prenosov: 125
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