621. Structural fire behaviourFelix Wiesner, Daniel Brandon, Andrea Lucherini, Pedro Palma, 2025, samostojni znanstveni sestavek ali poglavje v monografski publikaciji Povzetek: Fire safety and fire protection objectives require that buildings and parts of buildings do not collapse during a fire. This requires that the load-carrying capacity is maintained to a minimum acceptable level during a fire. This chapter briefly describes the historical background and state of the art of fire resistance and its determination for timber members through testing or calculations. The thermal and mechanical principles that underpin structural behaviour of wood at elevated temperatures are explained in the context of explicit calculation methods that enable explicit evaluation of the structural capacity beyond fire resistance, which is a formalised and codified assessment of structural elements against a standard fire. The importance of connections to the overall structure in fire is explained along with suitable design considerations. Ultimately, knowledge gaps with respect to novel and more complex engineered timber products for taller timber buildings are highlighted alongside potential limitations of established design parameters.
Ključne besede: fire resistance, fire safety, structures, load-carrying capacity, timber, connections
Objavljeno v DiRROS: 18.11.2025; Ogledov: 166; Prenosov: 73
 Celotno besedilo (1,01 MB)
Gradivo ima več datotek! Več... |
622. Nutrient profiling is needed to improve the nutritional quality of the foods labelled with health-related claimsUrška Pivk Kupirovič, Krista Miklavec, Maša Hribar, Anita Kušar, Katja Žmitek, Igor Pravst, 2019, izvirni znanstveni članek Ključne besede: food supply, health claim, nutrition claim, nutrient profile, nutrition quality, sales data, Slovenia
Objavljeno v DiRROS: 18.11.2025; Ogledov: 177; Prenosov: 73
Celotno besedilo (306,36 KB)
Gradivo ima več datotek! Več... |
623. Total and free sugars consumption in a Slovenian population representative sampleNina Mikec, Hristo Hristov, Matej Gregorič, Urška Blaznik, Nataša Delfar, Barbara Koroušić-Seljak, Eric L. Ding, Nataša Fidler Mis, Igor Pravst, 2020, izvirni znanstveni članek Ključne besede: free sugar, sugar intake, dietary intake, 24-hour recall, nutrition survey, public health, EU Menu, Slovenia
Objavljeno v DiRROS: 18.11.2025; Ogledov: 161; Prenosov: 71
Celotno besedilo (296,27 KB)
Gradivo ima več datotek! Več... |
624. Nutrihealth study : seasonal variation in vitamin D status among the Slovenian adult and elderly populationMaša Hribar, Hristo Hristov, Matej Gregorič, Urška Blaznik, Katja Zaletel, Adrijana Oblak, Joško Osredkar, Anita Kušar, Katja Žmitek, Irena Rogelj, Igor Pravst, 2020, izvirni znanstveni članek Ključne besede: 25(OH)vitamin D, biomarkers, dietary survey, public health, EU Menu, Slovenia, Europe
Objavljeno v DiRROS: 18.11.2025; Ogledov: 174; Prenosov: 117
Celotno besedilo (699,56 KB)
Gradivo ima več datotek! Več... |
625. |
626. Comparative bioavailability of different coenzyme Q10 formulations in healthy elderly IndividualsIgor Pravst, Juan Carlos Rodríguez Aguilera, Ana Belen Cortes Rodriguez, Janja Jazbar, Igor Locatelli, Hristo Hristov, Katja Žmitek, 2020, izvirni znanstveni članek Povzetek: Coenzyme Q10 (CoQ10) plays a central role in mitochondrial oxidative phosphorylation. Several studies have shown the beneficial effects of dietary CoQ10 supplementation, particularly in relation to cardiovascular health. CoQ10 biosynthesis decreases in the elderly, and consequently, the beneficial effects of dietary supplementation in this population are of greater significance. However, most pharmacokinetic studies have been conducted on younger populations. The aim of this study was to investigate the single-dose bioavailability of different formulations of CoQ10 in a healthy geriatric population. A randomized, three-period, crossover bioavailability study was conducted on 21 healthy older adults (aged 65-74). The treatment was a single dose with a one-week washout period. Three different formulations containing the equivalent of 100 mg of CoQ10 were used: Q10Vital water-soluble CoQ10 syrup (the investigational product-IP); ubiquinol capsules (the comparative product-CP); and ubiquinone capsules (the standard product-SP). Ubiquinone/ubiquinol was followed in the plasma for 48 h. An analysis of the ratio of the area under the baseline-corrected concentration curve (deltaAUC48) for total CoQ10 and a comparison to SP yielded the following: The bioavailability of CoQ10 in the IP was 2.4-fold higher (95% CI: 1.3-4.5; p = 0.002), while the bioavailability of ubiquinol (CP) was not significantly increased (1.7-fold; 95% CI: 0.9%3.1, p = 0.129). No differences in the redox status of the absorbed coenzyme Q10 were observed between formulations, showing that CoQ10 appeared in the blood mostly as ubiquinol, even if consumed as ubiquinone.
Ključne besede: coenzyme Q10, CoQ10, Q10Vital, ubiquinone, ubiquinol, bioavailability, water-soluble formulations, the elderly
Objavljeno v DiRROS: 18.11.2025; Ogledov: 162; Prenosov: 78
Celotno besedilo (387,63 KB)
Gradivo ima več datotek! Več... |
627. Effects of a combination of water-soluble coenzyme Q10 and collagen on skin parameters and condition : results of a randomised, placebo-controlled, double-blind studyKatja Žmitek, Janko Žmitek, Mirjam Rogl-Butina, Tina Pogačnik, 2020, izvirni znanstveni članek Ključne besede: skin, coenzyme Q10, collagen peptides, skin health, dermis density
Objavljeno v DiRROS: 18.11.2025; Ogledov: 190; Prenosov: 104
Celotno besedilo (1,97 MB)
Gradivo ima več datotek! Več... |
628. Dietary lutein supplementation protects against ultraviolet-radiation-induced erythema : results of a randomized double-blind placebo-controlled studyKatja Žmitek, Janko Žmitek, Mirjam Rogl-Butina, Hristo Hristov, Tina Pogačnik, Igor Pravst, 2020, izvirni znanstveni članek Ključne besede: lutein, minimal erythema dose, photoprotective activity, viscoelasticity, dermal density, carotenoids
Objavljeno v DiRROS: 18.11.2025; Ogledov: 181; Prenosov: 76
Celotno besedilo (557,89 KB)
Gradivo ima več datotek! Več... |
629. Emergency medical services utilisation among febrile children attending emergency departments across Europe : an observational multicentre studyChantal D. Tan, Clementien L. Vermont, Joany M. Zachariasse, Ulrich Von Both, Irini Eleftheriou, Marieke Emonts, Michiel Van der Flier, Jethro Adam Herberg, Marko Pokorn, 2023, izvirni znanstveni članek Povzetek: Children constitute 6–10% of all patients attending the emergency department (ED) by emergency medical services (EMS). However, discordant EMS use in children occurs in 37–61% with fever as an important risk factor. We aimed to describe EMS utilisation among febrile children attending European EDs. This study is part of an observational multicentre study assessing management and outcome in febrile children up to 18 years (MOFICHE) attending twelve EDs in eight European countries. Discordant EMS use was defined as the absence of markers of urgency including intermediate/high triage urgency, advanced diagnostics, treatment, and admission in children transferred by EMS. Multivariable logistic regression analyses were performed for the association between (1) EMS use and markers of urgency, and (2) patient characteristics and discordant EMS use after adjusting all analyses for the covariates age, gender, visiting hours, presenting symptoms, and ED setting. A total of 5464 (15%, range 0.1–42%) children attended the ED by EMS. Markers of urgency were more frequently present in the EMS group compared with the non-EMS group. Discordant EMS use occurred in 1601 children (29%, range 1–59%). Age and gender were not associated with discordant EMS use, whereas neurological symptoms were associated with less discordant EMS use (aOR 0.2, 95%CI 0.1–0.2), and attendance out of office hours was associated with more discordant EMS use (aOR 1.6, 95%CI 1.4–1.9). Settings with higher percentage of self-referrals to the ED had more discordant EMS use (p < 0.05). Conclusion: There is large practice variation in EMS use in febrile children attending European EDs. Markers of urgency were more frequently present in children in the EMS group. However, discordant EMS use occurred in 29%. Further research is needed on non-medical factors influencing discordant EMS use in febrile children across Europe, so that pre-emptive strategies can be implemented.
Ključne besede: emergency medical services, emergency care, children, fever, paediatrics
Objavljeno v DiRROS: 17.11.2025; Ogledov: 158; Prenosov: 59
Celotno besedilo (1,07 MB)
Gradivo ima več datotek! Več... |
630. Relationship between molecular pathogen detection and clinical disease in febrile children across Europe : a multicentre, prospective observational studyPriyen Shah, Marie Voice, Leonides Calvo-Bado, Irene Rivero Calle, Sophie Morris, Ruud Nijman, Claire Broderick, Tisham De, Mojca Kolnik, Katarina Vincek, Marko Pokorn, 2023, izvirni znanstveni članek Povzetek: Background: The PERFORM study aimed to understand causes of febrile childhood illness by comparing molecular pathogen detection with current clinical practice. Methods: Febrile children and controls were recruited on presentation to hospital in 9 European countries 2016–2020. Each child was assigned a standardized diagnostic category based on retrospective review of local clinical and microbiological data. Subsequently, centralised molecular tests (CMTs) for 19 respiratory and 27 blood pathogens were performed. Findings: Of 4611 febrile children, 643 (14%) were classified as definite bacterial infection (DB), 491 (11%) as definite viral infection (DV), and 3477 (75%) had uncertain aetiology. 1061 controls without infection were recruited. CMTs detected blood bacteria more frequently in DB than DV cases for N. meningitidis (OR: 3.37, 95% CI: 1.92–5.99), S. pneumoniae (OR: 3.89, 95% CI: 2.07–7.59), Group A streptococcus (OR 2.73, 95% CI 1.13–6.09) and E. coli (OR 2.7, 95% CI 1.02–6.71). Respiratory viruses were more common in febrile children than controls, but only influenza A (OR 0.24, 95% CI 0.11–0.46), influenza B (OR 0.12, 95% CI 0.02–0.37) and RSV (OR 0.16, 95% CI: 0.06–0.36) were less common in DB than DV cases. Of 16 blood viruses, enterovirus (OR 0.43, 95% CI 0.23–0.72) and EBV (OR 0.71, 95% CI 0.56–0.90) were detected less often in DB than DV cases. Combined local diagnostics and CMTs respectively detected blood viruses and respiratory viruses in 360 (56%) and 161 (25%) of DB cases, and virus detection ruled-out bacterial infection poorly, with predictive values of 0.64 and 0.68 respectively. Interpretation: Most febrile children cannot be conclusively defined as having bacterial or viral infection when molecular tests supplement conventional approaches. Viruses are detected in most patients with bacterial infections, and the clinical value of individual pathogen detection in determining treatment is low. New approaches are needed to help determine which febrile children require antibiotics.
Ključne besede: molecular diagnostics, diagnostic, febrile illness, infectious disease, bacterial infection, viral infection, respiratory infection
Objavljeno v DiRROS: 17.11.2025; Ogledov: 172; Prenosov: 74
Celotno besedilo (2,67 MB)
Gradivo ima več datotek! Več... |
