261. A pilot study on the replacement of fibrinogen with fibrinogen concentrates during therapeutic plasma exchange with mild to moderate bleeding risk : a comparison with fresh frozen plasma and albumin replacementMatej Zrimšek, Jakob Gubenšek, Andreja Marn-Pernat, 2024, izvirni znanstveni članek Povzetek: Background: Therapeutic plasma exchange (TPE) removes coagulation factors and leads to depletion coagulopathy. The aim of the study was to compare hemostasis between TPE procedures without coagulation factor replacement (electrolyte group), the partial replacement of fibrinogen with fibrinogen concentrates (fibrinogen group) and partial coagulation factors replacement with fresh frozen plasma (partial FFP group). Methods: A total of 73 TPE procedures in patients with fibrinogen levels 1–2 g/L were divided into three study groups depending on clinically estimated bleeding risk. Standard coagulation and ROTEM® tests were performed before and after TPE. Results: Fibrinogen levels before TPE (p = 0.88) and after TPE (p = 0.33) were comparable between the fibrinogen and partial FFP groups. INR and ROTEM® parameters reflected moderately worse hemostasis after TPE with fibrinogen-only replacement compared to partial FFP replacement, which could result in increased bleeding risk. In the electrolyte group, most laboratory tests confirmed the most deranged hemostasis after TPE, as compared to fibrinogen or partial FFP replacement. A mild allergic reaction to FFP infusion was noted during one TPE. No clinically significant bleeding occurred in any of the study groups. Conclusions: Fibrinogen concentrate supplementation and partial FFP replacement can both maintain fibrinogen levels > 1 g/L after TPE, but modest differences in classical coagulation tests and bedside ROTEM® tests favor FFP replacement (NCT03801135).
Ključne besede: therapeutic plasma exchange, coagulation, fibrinogen concentrate, fresh frozen plasma, bleeding risk
Objavljeno v DiRROS: 01.12.2025; Ogledov: 139; Prenosov: 68
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262. Complications on the feeding artery after an arterio-venous fistula closure in patients after kidney transplantation : a national cohort studyMatej Zrimšek, Barbara Vajdič Trampuž, Matija Jelenc, Juš Kšela, Jakob Gubenšek, 2025, izvirni znanstveni članek Povzetek: Background: Arteriovenous fistulas (AVFs) in kidney transplant recipients are sometimes closed, either as a policy or due to complications. We collected data on the incidence of complications after AVF closure in a national cohort of transplanted patients. Methods: Patients who received a kidney transplant between 2000 and 2015 and had a functional AVF that was later ligated or extirpated were included. Medical records were searched for arterial complications on the arm with the closed AVF. Furthermore, all patients who were still alive in January 2023 were invited for a follow-up arterial ultrasound exam. Results: Sixty patients were included; mean follow-up was 9.3 ± 3.8 years. There were five (8% cumulative incidence) patients with symptomatic arterial thrombosis and three (5% incidence) with a symptomatic feeding artery aneurysm. Prospective ultrasound exams were performed in 50 patients; the mean diameter of the brachial artery was almost doubled on the arm with the closed AVF (8.1 ± 3.2 versus 4.7 ± 0.7 mm; P < .001). Additional asymptomatic complications were found in nine patients (18% incidence): seven cases (14% incidence) of arterial thrombosis, some extending up to the axillary artery, and three (6% incidence) brachial artery aneurysms. All patients in whom the thrombosis spread to the brachial artery had large brachial arteries (>10 mm) or an aneurysm. Conclusion: We observed a high cumulative incidence of arterial thrombosis (20%) and brachial artery aneurysms (10%), sometimes developing several years after AVF closure. These complications should be taken into account when contemplating closure of a well-developed AVF and an AVF-preserving approach with flow reduction surgery might be preferred in some cases.
Ključne besede: kidney transplantation, arterial thrombosis, arteriovenous fistula, complications, true brachial artery aneurysm, ultrasound exam
Objavljeno v DiRROS: 01.12.2025; Ogledov: 195; Prenosov: 61
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263. Haptoglobin as a novel predictor of visceral involvement and relapse in adult IgAV patientsMatija Bajželj, Nina Visočnik, Katjuša Mrak Poljšak, Matjaž Hladnik, Katja Lakota, Alojzija Hočevar, 2025, izvirni znanstveni članek Povzetek: Introduction: IgA vasculitis (IgAV) can present as skin-limited or systemic disease, which can be severe in adults. Predictive markers for visceral involvement are suboptimal. Considering haptoglobin's role as an acute phase reactant, we evaluated whether its differential expression in IgAV patients' skin and leukocytes is also reflected systemically in a larger cohort of adult IgAV patients. Additionally, soluble form of haptoglobin scavenger receptor CD163 was measured in IgAV patient serum. Methods: We re-analyzed RNA sequencing data from leukocytes and skin biopsies of treatment-naïve adult IgAV patients: (1) IgAV nephritis (n = 3), (2) skin-limited IgAV (n = 3), and healthy controls (n = 3). Haptoglobin serum level was measured in 178, and haptoglobin genotyping was performed in 91 treatment-naïve adult IgAV patients. Serum sCD163 was measured in 60 IgAV patients and 22 HC. Results: Transcriptomic data of leukocytes and skin of IgAV nephritis patients identified haptoglobin as a hub gene, based on protein-protein interaction network. Haptoglobin serum level was elevated in IgAV patients with nephritis or gastrointestinal involvement compared to other IgAV patients. Patients who relapsed during follow-up had decreased haptoglobin serum level at disease presentation compared to non-relapsing patients. Haptoglobin genotyping did not show differences between genotype groups regarding clinical presentation and laboratory parameters. Serum sCD163 was significantly higher in IgAV nephritis patients compared to HC. Conclusion: We identified haptoglobin as a novel marker of visceral involvement and relapse in adult IgAV, while sCD163 is linked to renal involvement. Further studies will confirm the clinical utility of haptoglobin as biomarker in IgAV. Key Points • Haptoglobin expression is upregulated in leukocytes and skin of adult IgAV with renal involvement. • Haptoglobin serum level is elevated in IgAV patients with visceral involvement. • Patients with IgAV relapse have lower haptoglobin at disease presentation.
Ključne besede: hepatoglobin, IgA vasculitis, transcription data, biomarker
Objavljeno v DiRROS: 01.12.2025; Ogledov: 132; Prenosov: 60
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264. The new occurrence of antiphospholipid syndrome in severe COVID-19 cases with pneumonia and vascular thrombosis could explain the post-COVID syndromeMirjana Zlatković Švenda, Melanija Rašić, Milica Ovuka, Slavica Pavlov Dolijanović, Marija Atanasković Popović, Manca Ogrič, Polona Žigon, Snežna Sodin-Šemrl, Marija Zdravković, Goran Radunović, 2025, izvirni znanstveni članek Povzetek: Introduction: The classification of antiphospholipid syndrome (APS) comprises clinical criteria (vascular thrombosis or obstetric complications throughout life) and laboratory criteria (antiphospholipid antibodies (aPLs) positivity, confirmed at least twice at 12-week interval). Methods: In 100 patients admitted to the hospital with COVID-19 pneumonia, thrombosis and pregnancy complications were recorded during the hospital stay and in personal medical history. They were tested for nine types of aPLs at four time points (admission, deterioration, discharge, and 3-month follow-up): anticardiolipin (aCL), anti-β2-glycoproteinI (anti-β2GPI), and antiphosphatidylserine/prothrombin (aPS/PT) isotypes IgM/IgG/IgA. Results: During hospitalization, aPLs were detected at least once in 51% of patients. All 7% of deceased patients tested negative for aPLs upon admission, and only one patient became aCL IgG positive as his condition worsened. In 83.3% of patients, intrahospital thrombosis was not related to aPLs. One patient with pulmonary artery and cerebral artery thrombosis was given an APS diagnosis (triple aPLs positivity on admission, double on follow-up). Personal anamnesis (PA) for thromboembolism was verified in 10 patients, all of whom tested negative for aPLs at admission; however, transition to aPLs positivity at discharge (as the disease subsided) was seen in 60% of patients: three of six with arterial thrombosis (at follow-up, two did not appear, and one was negativized) and three of four with deep vein thrombosis (one was confirmed at follow-up and diagnosed with APS, one was negativized, and one did not appear). At admission, the majority of the aPLs were of the aCL IgG class (58.8%). Unexpectedly, as the COVID-19 disease decreased, anti-β2GPI IgG antibodies (linked with thromboses) became newly positive at discharge (14.9%), as confirmed at follow-up (20.8%). Conclusion: The incidence of APS in our cohort was 2.0%, whereas in the general population, it ranges from 0.001% to 0.002%. The incidence might have increased even more if the four aPLs-positive patients with intrahospital thrombosis/history of thrombosis had attended follow-up. Recommendation: All patients with severe COVID-19 or post-COVID syndrome should be evaluated for current/previous thrombosis and tested for aPLs at least twice: at admission to the hospital and at discharge, then retested 3 months later in positive cases in order to be given the appropriate therapy.
Ključne besede: COVID-19, SARS-CoV2, anti-phosphatidylserine-prothrombin (aPS/PT) antibodies, anti-β2-glycoprotein I (anti-β2GPI) antibodies, anticardiolipin (aCL) antibodies, antiphospholipid antibodies (aPLs), antiphospholipid syndrome, immunology, post-COVID syndrome, vascular thrombosis
Objavljeno v DiRROS: 01.12.2025; Ogledov: 147; Prenosov: 68
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265. Global Impacts Dataset of Invasive Alien Species (GIDIAS)Sven Bacher, Ellen Ryan-Colton, Mario Coiro, Phillip Cassey, Bella S. Galil, Martin A. Nuñez, Michael Ansong, Katharina Dehnen-Schmutz, Georgi Fayvush, Romina D. Fernandez, Maarten De Groot, 2025, zaključena znanstvena zbirka raziskovalnih podatkov Povzetek: We present the Global Impacts Dataset of Invasive Alien Species (GIDIAS), a global dataset of 22865 records including impacts of invasive alien species on nature, nature’s contributions to people, and good quality of life. Records include positive and negative impacts, neutral impacts (studies were carried out, but no impacts were documented), non-directional impacts (i.e., change without detriments or benefits for native species or people), and finally, some records of alien species where no studies were found that assessed their impacts (indicating data gaps). Records cover 3353 invasive alien species from all major taxa (plants, vertebrates, invertebrates, microorganisms) and all continents and realms (terrestrial, freshwater, marine). The data were compiled to serve as robust evidence for chapter 4 “Impacts of invasive alien species on nature, nature's contributions to people, and good quality of life” of the global assessment report on invasive alien species by the Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services (IPBES; available on Zenodo at https://doi.org/10.5281/zenodo.7430731). The dataset is provided in a machine-readable CSV file (file name GIDIAS_20250417_machine_read.csv), with special language characters retained where used (UTF-8 format). The dataset is also provided in Excel format (file name GIDIAS_20250417_Excel.xlsx). Metadata is provided in Excel format, including descriptors for each variable (file name GIDIAS_metadata_20250417.xlsx). Additional explanations for GIDIAS is stored in Microsoft Word format (docx) and contains (1) a short description of the principles of Environmental and Socio-Economic Impact Classification for Alien Taxa (EICAT, SEICAT), (2) a description of the variables included in the Global Impacts Dataset of Invasive Alien Species GIDIAS, and (3) a compilation of the search strategies and datasets included in the Global Impact Dataset of Invasive Alien Species (GIDIAS).
Ključne besede: invasive alien species, research data
Objavljeno v DiRROS: 01.12.2025; Ogledov: 151; Prenosov: 63
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266. Reliability of spino-pelvic and sagittal balance parameters assessed during walking in patients with back painArmand Dominik Škapin, Janez Vodičar, Nina Verdel, Matej Supej, Miha Vodičar, 2025, izvirni znanstveni članek Ključne besede: sport, degenerative spine disease, sagittal balance, gait analysis, synamic assessment, motion capture
Objavljeno v DiRROS: 01.12.2025; Ogledov: 137; Prenosov: 67
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267. The Prevalence of bacterial vaginosis in pregnant women in Slovenia, determined via microscopy and semi-quantitative relative culture, and its association with adverse pregnancy outcomesMaja Starc, Miha Lučovnik, Petra Eržen Vrlič, Samo Jeverica, 2025, izvirni znanstveni članek Povzetek: Bacterial vaginosis (BV) is associated with various adverse pregnancy outcomes. It is usually diagnosed via microscopy. Semi-quantitative relative culture (SRC) was investigated as a complementary diagnostic method to determine the prevalence of BV and its association with preterm birth and preterm, premature rupture of membranes (PPROM) in pregnant women in Slovenia. We examined 3437 consecutive vaginal swabs from pregnant women during the five-year period and were able to link the results to 2531 pregnancy outcomes. The isolates were identified using MALDI-TOF, and the results were assessed by the relative amounts of Gardnerella vaginalis and lactobacilli according to two stringency criteria. The prevalence of BV was 6.5% via microscopy and was higher for SRC, 9.9% or 11.1%, depending on the stringency criteria. The association with adverse pregnancy outcomes was better when SRC was used, resulting in adjusted odds ratios of 1.76 (1.30 to 2.37) and 1.97 (1.38 to 2.82) for preterm birth and PPROM, respectively, with more stringent interpretation. Microscopically detected BV was not associated with either outcome. The clinical validity of SRC was demonstrated by its better correlation with adverse pregnancy outcomes in a large cohort of pregnant women. SRC with MALDI-TOF identification is a promising advancement of vaginal culture.
Ključne besede: bacterial vaginosis, culture, microscopy, pregnancy, preterm birth, preterm premature rupture of membranes, Slovenia
Objavljeno v DiRROS: 01.12.2025; Ogledov: 115; Prenosov: 53
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268. First-line anti-TNF agents, ustekinumab and vedolizumab perform similarly in Crohn' disease, but not in ulcerative colitisEva Supovec, Jurij Hanžel, Gregor Novak, Damjan Manevski, Borut Štabuc, David Drobne, 2025, izvirni znanstveni članek Povzetek: Background: Real-word comparisons between first-line biologicals in inflammatory bowel disease (IBD) are scarce. Aims: The aim of this study is to compare drug persistence and patient reported outcome-2 (PRO-2) remission rates of first-line biological classes [anti-tumor necrosis factor (TNF) agents vs anti-integrin vedolizumab vs IL-12/23 inhibitor ustekinumab] in real life cohort. Methods: Individual level data of 946 adults (588 Crohn's disease and 358 ulcerative colitis) were retrieved from UR-CARE IBD platform. Adjusted drug survival curves using a pooled logistic model and PRO-2 remission rates for each class of biologicals were calculated and compared. Results: In Crohn's disease, no differences in drug survival were observed for anti-TNF agents vs vedolizumab vs ustekinumab as estimated survival with 95% confidence intervals were 0.81 (0.77-0.84) vs 0.89 (0.82-0.96) vs 0.88 (0.79-0.97) at year 1 and 0.52 (0.46-0.58) vs 0.58 (0.37-0.78) vs 0.58 (0.39-0.77) at year 4. In ulcerative colitis, however, anti-TNF agents had shorter drug survival than vedolizumab with estimated drug survival with 95% confidence intervals 0.60 (0.52-0.67) vs 0.76 (0.67-0.84) at year 1 and 0.37 (0.30-0.44) vs 0.50 (0.36-0.64) at year 4. No differences in PRO-2 remission rates were observed between drug classes in Crohn's disease (P = 0.95), but more patients enjoyed PRO-2 remission in ulcerative colitis treated with anti-TNF agents compared to vedolizumab (94.8 vs 78.9%, P = 0.002). Conclusion: Our real-world data suggest similar drug persistence and efficacy of first-line treatments with anti-TNF agents, vedolizumab and ustekinumab in Crohn's disease. In ulcerative colitis, however, drug persistence was higher for vedolizumab compared to anti-TNF agents, but on the cost of lower PRO-2 remission rates.
Ključne besede: anti-TNF agents, ustekinumab, vedolizumab
Objavljeno v DiRROS: 01.12.2025; Ogledov: 136; Prenosov: 66
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269. Maternal fatigue after postpartum anemia treatment with intravenous ferric carboxymaltose vs. intravenous ferric derisomaltose vs. oral ferrous sulphate : a randomized controlled trialLea Bombač Tavčar, Hana Hrobat, Lea Gornik, Irena Preložnik Zupan, Marijana Vidmar Šimic, Polona Pečlin, Gorazd Kavšek, Miha Lučovnik, 2024, izvirni znanstveni članek Povzetek: (1) Background: Postpartum anemia is a common maternal complication and is recognized as a cause of impaired quality of life, reduced cognitive abilities, and fatigue. Efficient iron supplementation for the treatment of postpartum anemia is an essential component of high-quality maternal care. The optimal mode of iron supplementation has not been determined yet, whether oral or intravenous. The objective of this study was to compare postpartum anemia treatment with intravenous ferric carboxymaltose, intravenous ferric derisomaltose, and oral ferrous sulfate. (2) Methods: A single-center, open-label, randomized controlled trial. Women with hemoglobin < 100 g/L within 48 h postpartum were randomly allocated to receive intravenous ferric carboxymaltose, intravenous ferric derisomaltose, or oral ferrous sulfate. Intravenous iron was given in one or two doses, while ferrous sulfate was given as two 80 mg tablets once daily. The primary outcome was maternal fatigue measured by the Multidimensional Fatigue Inventory (MFI) six weeks postpartum. Hemoglobin, ferritin, and transferrin saturation levels were analyzed as secondary outcomes. A Kruskal–Wallis test was used for group comparison (p < 0.05 significant). (3) Results: Three hundred women were included. The MFI score at six weeks postpartum did not differ between groups (median 38 (inter-quartile range (IQR) 29–47) in the ferric carboxymaltose group, median 34 (IQR 26–42) in the ferric derisomaltose group, and median 36 (IQR 25–47) in the ferrous sulfate group; p = 0.26). Participants receiving oral iron had lower levels of hemoglobin (135 (131–139) vs. 134 (129–139) vs. 131 (125–137) g/L; p = 0.008), ferritin (273 (198–377) vs. 187 (155–246) vs. 24 (17–37) µg/L; p < 0.001) and transferrin saturation (34 (28–38) vs. 30 (23–37) vs. 24 (17–37) %; p < 0.001) than those receiving ferric carboxymaltose or ferric derisomaltose. (4) Conclusions: Intravenous ferric carboxymaltose, intravenous ferric derisomaltose, and oral ferrous sulfate had similar impacts on maternal fatigue at six weeks postpartum despite improved laboratory parameters in the intravenous groups.
Ključne besede: postpartum anemia, fatigue, intravenous iron treatment, oral iron replacement, patient-centered outcome
Objavljeno v DiRROS: 01.12.2025; Ogledov: 173; Prenosov: 67
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270. Fecal short-chain fatty acids are associated with obesity in gestational diabetesKatja Molan, Jerneja Ambrožič, Matevž Likar, Draženka Pongrac Barlovič, Darja Žgur-Bertok, Marjanca Starčič Erjavec, 2025, izvirni znanstveni članek Povzetek: Background: Short-chain fatty acids (SCFAs), which are produced by the microbial fermentation of undigested carbohydrates, play an important role in the metabolism and physiology of the host. SCFAs are involved in the regulation of maternal metabolism during pregnancy and influence weight gain, glucose metabolism, and metabolic hormones. Methods: In 2017, women who were treated for gestational diabetes mellitus (GDM) at the University Medical Centre Ljubljana were invited to participate in a longitudinal study. A total of 45 women were included in this study and comprehensively phenotyped. During the second and third trimester of pregnancy, the women with GDM provided fecal samples for SCFA analysis. The samples were analyzed by high-performance liquid chromatography for the simultaneous determination of acetate, propionate, and butyrate. Results: SCFA concentrations in feces differed between overweight/obese and normal-weight women with GDM. Acetate and propionate concentrations were significantly higher in pregnant women who were overweight or obese before pregnancy compared to normal-weight women but butyrate concentrations were not. Butyrate was elevated in the third trimester in the group with excessive gestational weight gain. Conclusions: The relationship between SCFAs and obesity is complex, and the association between SCFAs and GDM remains to be clarified. Regardless of the conflicting publications on the role of SCFAs, our study showed that higher acetate and propionate levels were associated with the weight categories of overweight or obesity before pregnancy and higher butyrate levels were associated with excessive gestational weight gain.
Ključne besede: fecal SCFA, pregnancy, gestational diabetes mellitus, preconception BMI, gestational weight gain
Objavljeno v DiRROS: 01.12.2025; Ogledov: 126; Prenosov: 65
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