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392. Interplay of anxiety, depression, vascular function, and biomarkers in post-myocardial infarction patientsJan Kafol, Borut Jug, Mojca Božič Mijovski, Jure Tršan, Daniel Košuta, Marko Novaković, 2025, izvirni znanstveni članek Povzetek: Background and aims: Coronary artery disease (CAD) is a leading cause of mortality. Depression and anxiety are common in CAD patients and negatively affect quality of life, physical functioning, and adherence to cardiac rehabilitation (CR) programs. This study aimed to identify possible associations with clinically relevant parameters, vascular function and blood biomarkers. Methods: Participants were consecutively recruited during cardiac rehabilitation intake visits at the University Medical Centre Ljubljana within 4 months of myocardial infarction (MI). Hospital Anxiety and Depression Scale (HADS) scores were analyzed in relation to endothelial function (assessed with flow-mediated dilation), arterial stiffness, and blood biomarkers (fibrinogen, endocan, and brain-derived neurotrophic factor [BDNF]) in post-MI patients. All vascular and biomarker assessments were performed within 5 days of questionnaire completion and prior to the start of rehabilitation. Results: There were 105 patients included in the study. The median age was 56 years (49–62), and 80.0% of participants were male. Clinically relevant anxiety and depression were present in 29.5% and 21.9% of participants, respectively. Anxiety was significantly associated with younger age, higher body mass index, and increased arterial stiffness, with total HADS scores negatively correlated with age. Endothelial function showed no significant associations with HADS scores. Vital signs showed no significant differences, except for slightly higher systolic blood pressure in those with clinically relevant depression. Fibrinogen levels were significantly higher in participants with anxiety and depression, while endocan and BDNF levels were lower in those with anxiety. Conclusion: Depression and especially anxiety are significantly associated with endothelial function and relevant biomarkers in post-MI patients. However, as HADS is a screening tool and not a diagnostic instrument, and given the study’s observational design, findings reflect associations rather than causality. Routine screening and targeted mental health support within CR programs might improve participation, enhance cardiovascular recovery, and optimize long-term outcomes. These findings underscore the clinical importance of psychological assessment in the early post-MI period and support the integration of mental health evaluation into cardiovascular care.
Ključne besede: anxiety, depression, cardiac rehabilitation, coronary artery disease, myocardial infarction, pulse-wave velocity, endothelial dysfunction
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393. Slovenian national food consumption survey on children (infants and toddlers) : external scientific reportUrška Blaznik, Matej Gregorič, Nataša Delfar, Metka Zaletel, Darja Lavtar, Barbara Koroušić-Seljak, Nataša Fidler Mis, Petra Golja, Katja Zdešar Kotnik, Igor Pravst, Ada Hočevar-Grom, 2019, končno poročilo o rezultatih raziskav Ključne besede: Slovenia, food consumption survey, dietary intake, infants, toddlers, children, EU Menu
Objavljeno v DiRROS: 24.11.2025; Ogledov: 157; Prenosov: 78
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395. Ticagrelor is associated with increased rosuvastatin blood concentrations in patients who have had a myocardial infarctionTjaša Dermota, Borut Jug, Jurij Trontelj, Mojca Božič Mijovski, 2025, izvirni znanstveni članek Povzetek: Aims: The primary objective of this study was to determine whether concomitant therapy with ticagrelor and rosuvastatin affects rosuvastatin plasma concentrations in patients receiving rosuvastatin 40 mg/day after myocardial infarction. Methods: We included 93 patients who had experienced a myocardial infarction and were receiving high-dose rosuvastatin 40 mg/day and a P2Y12 receptor antagonist, either ticagrelor, prasugrel or clopidogrel. We used liquid chromatography with tandem mass spectrometry to measure rosuvastatin plasma concentrations after liquid–liquid extraction. Results: Rosuvastatin plasma concentrations (9.7 ng/mL) were approximately twice as high in patients receiving ticagrelor therapy as in those receiving prasugrel (5.1 ng/mL, p<0.001) or clopidogrel (5.0 ng/mL, p=0.009), and ticagrelor was an independent factor influencing rosuvastatin concentrations. In addition, creatinine levels were associated with increased rosuvastatin concentrations (p=0.039). Conclusion: Our results suggest an important pharmacokinetic interaction between ticagrelor and rosuvastatin, leading to approximately two-fold higher rosuvastatin plasma concentrations in those receiving concomitant ticagrelor than in those receiving prasugrel or clopidogrel. The association is significant and independent of other potential factors influencing rosuvastatin levels, indicating its potential clinical relevance.
Ključne besede: clopidogrel, drug interactions, rosuvastatin, pharmacokinetics, ticagrelor, concomitant therapy, pharmacokinetic interaction, myocardial infarction
Objavljeno v DiRROS: 24.11.2025; Ogledov: 117; Prenosov: 64
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399. Slovenian national food consumption survey in adolescents, adults and elderly : external scientific reportMatej Gregorič, Urška Blaznik, Nataša Delfar, Metka Zaletel, Darja Lavtar, Barbara Koroušić-Seljak, Petra Golja, Katja Zdešar Kotnik, Igor Pravst, Nataša Fidler Mis, Stojan Kostanjevec, Majda Pajnkihar, Tamara Poklar Vatovec, Ada Hočevar-Grom, 2019, končno poročilo o rezultatih raziskav Ključne besede: Slovenia, food consumption survey, dietary intake, adults, adolescents, elderly, EU Menu
Objavljeno v DiRROS: 24.11.2025; Ogledov: 112; Prenosov: 83
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400. Extracellular vesicle-derived bioactive molecules for corneal and ocular surface regenerationAna Kolenc, Živa Dimnik, Miha Marzidovšek, Petra Schollmayer, Marko Hawlina, Elvira Maličev, Zala Lužnik Marzidovšek, 2025, pregledni znanstveni članek Povzetek: Cell-based therapies emerge as potential treatment options for various debilitating diseases. Preclinical research and clinical studies involving cells increased exponentially in the past decade. In addition to cell-based approaches, the use of extracellular vesicles (EVs), which are released by nearly all cell types, emerged as a promising cell-free alternative. Those approaches are also being explored in the field of ophthalmology. Several clinical trials involving EVs are underway to develop potential treatments for advanced ocular surface diseases, including corneal disorders, injuries, and dry eye disease. The cargo carried by EVs has been shown to include a diverse array of functional molecules such as transcription factors, cytokines, growth factors, mRNA, tRNA, rRNA, miRNA, and fragments of dsDNA. While the molecular composition of EVs is already well characterised, the specific activity of these molecules upon delivery to recipient cells remains poorly understood. In this review, we summarise recent studies investigating the bioactive molecules within EVs shown to influence or modulate cellular activity on the ocular surface. Among these, various miRNAs have most commonly been identified as therapeutic agents targeting distinct molecular pathways. The EVs studied were predominantly derived from various mesenchymal stem cells.
Ključne besede: extracellular vesicles, bioactive molecules, cornea, dry eye disease, miRNA, mesenchymal stem cells, ophthalmology
Objavljeno v DiRROS: 24.11.2025; Ogledov: 130; Prenosov: 66
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