1. Tumor size and effectiveness of electrochemotherapyBarbara Mali, Damijan Miklavčič, Luca Giovanni Campana, Maja Čemažar, Gregor Serša, Marko Snoj, Tomaž Jarm, 2013, izvirni znanstveni članek Ključne besede: electrochemotherapy, cutaneous tumors, effectiveness, tumor size, meta-analysis Objavljeno v DiRROS: 22.03.2024; Ogledov: 244; Prenosov: 83 Celotno besedilo (665,53 KB) |
2. First experience with a novel luminescence-based optical sensor for measurement of oxygenation in tumorsTomaž Jarm, Hotimir Lešničar, Gregor Serša, Damijan Miklavčič, 2001, izvirni znanstveni članek Povzetek: Background. The purpose of this preliminary study was to evaluate a novel luminescence-based fiber-optic sensor (OxyLite system) for the measurement of partial pressure of oxygen (pO2) in tumors and for the detection of changes inpO2 as a function of time. The new method was used simultaneously with the laser Doppler flowmetry method for the measurement of relative tissue perfusion. Materials and methods. Blood perfusion and pO2 were measured continuously via fiber-optic sensors inserted into SA-1 tumors in anesthetizedAžJ mice. The changes in blood flow and oxygenation of tumors wereinduced by transient changes of the parameters of anesthesia and by injection of a vasoactive drug hydralazine. Results. Both optical methods usedin the study successfully detected the induced changes in blood flow and pO2. The measurements of pO2 were well correlated with measurements of microcirculatory blood perfusion. In the majority of pO2 measurements, we observed an unexpected behavior of the signal during the stabilization processimmediately after the insertion of the probe into tumor. This behaviourof the pO2 signal was most probably caused by local tissue damage induced by the insertion of the probe. Conclusion. The novel luminescence-based optical oximetry can reliably detect local pO2 changes in tumors as a function of time but some aspects of prolonged pO2 measurement by this method require further investigation. Ključne besede: sarcoma experimental, blood supply, laser-doppler flowmetry, oxygen, luminiscence Objavljeno v DiRROS: 25.01.2024; Ogledov: 311; Prenosov: 99 Celotno besedilo (231,19 KB) |
3. Study of blood perfusion with patent blue staining method in LPB fibrosarcoma tumors in immuno-competent and immuno-deficient mice after electrotherapy by direct currentTomaž Jarm, Dong Jian An, Jean Belehradek, Lluis M. Mir, Gregor Serša, Maja Čemažar, Tadej Kotnik, Jani Pušenjak, Damijan Miklavčič, 1997, izvirni znanstveni članek Objavljeno v DiRROS: 16.01.2024; Ogledov: 291; Prenosov: 71 Celotno besedilo (344,22 KB) |
4. Improved therapeutic effect of electrochemotherapy with cisplatin by intratumoral drug administration and changing of electrode orientation for electropermeabilization on EAT tumor model in miceMaja Čemažar, Damijan Miklavčič, Lojze Vodovnik, Tomaž Jarm, Zvonimir Rudolf, Borut Štabuc, Tanja Čufer, Gregor Serša, 1995, izvirni znanstveni članek Ključne besede: neoplasmas, experimental therapy, cisplatin, electric stimulation therapy, cell membrane permeability Objavljeno v DiRROS: 15.01.2024; Ogledov: 263; Prenosov: 69 Celotno besedilo (393,12 KB) |