11. Nanovaccines to combat drug resistance : the next-generation immunisationK. Manju, S. Niranjan Raj, Raghuraj S. Chouhan, Syed Baker, 2023, pregledni znanstveni članek Povzetek: Background. The present review envisages the role of nanovaccines to combat the global challenges of antimicrobial resistance. Nanovaccines are a novel formulation comprised of nanomaterials coupled with an immunogenic component to elicit the immune response and provide protection against the desired infectious disease. The nanovaccines with unique physicochemical properties can be more efficient against targeting the desired tissues in the body, aids in prolong circulation to promote antigen-presenting cells to act upon the target antigens. Main content. The present review envisages the development of nanovaccines against antimicrobial-resistant pathogens. The use of nanovaccines can exhibit potent antigenicity with prolonged retention and controlled release to induce both cell- and antibody-mediated responses. Nanovaccines usage is still in the early stages and can be next-generation immunisation for prophylactic and therapeutic efficiency. The future development of nanovaccines against multi-drug-resistant pathogens can explore new avenues. Based on these facts, the present review is designed from the previously reported scientific studies and compiled with the fact that nanovaccines can revolutionise vaccine strategies. The articles were extracted from reputed databases like PubMed, Scopus, and ESCI. The size and conjugating chemistry of nanomaterials can be beneficial in developing novel multi-nanovaccine formulations that can target pools of antimicrobial resistance mechanisms. Conclusion. Overall, the nanovaccines can form one of the best effective modes of targeting multi-drug-resistant pathogens. The nanovaccines can stimulate the innate immune response and generate effective immune-therapeutic novel formulation against infectious pathogens. Based on these facts and considerations, the present article makes an alarming call to develop nanovaccines to counter multi-drug resistance.
Ključne besede: nanovaccines, antimicrobial drug resistance, nanomaterials, HIV, WHO
Objavljeno v DiRROS: 16.12.2025; Ogledov: 10; Prenosov: 6
 Celotno besedilo (1,39 MB)
Gradivo ima več datotek! Več... |
12. Algorithms for distance problems in continuous graphsSergio Cabello, Delia Garijo, Antonia Kalb, Fabian Klute, Irene Parada, Rodrigo I. Silveira, 2025, objavljeni znanstveni prispevek na konferenci Povzetek: We study the problem of computing the diameter and the mean distance of a continuous graph, i.e., a connected graph where all points along the edges, instead of only the vertices, must be taken into account. It is known that for continuous graphs with $m$ edges these values can be computed in roughly $O(m^2)$ time. In this paper, we use geometric techniques to obtain subquadratic time algorithms to compute the diameter and the mean distance of a continuous graph for two well-established classes of sparse graphs. We show that the diameter and the mean distance of a continuous graph of treewidth at most $k$ can be computed in $O(n \log^{O(k)} n)$ time, where $n$ is the number of vertices in the graph. We also show that computing the diameter and mean distance of a continuous planar graph with $n$ vertices and $F$ faces takes $O(n F \log n)$ time.
Ključne besede: diameter, mean distance, continuous graphs, treewidth, planar graphs
Objavljeno v DiRROS: 16.12.2025; Ogledov: 8; Prenosov: 7
Celotno besedilo (946,64 KB)
Gradivo ima več datotek! Več... |
13. Boosting copper biocidal activity by silver decoration and few-layer graphene in coatings on textile fibersDanaja Štular, Nigel Willy Van de Velde, Ana Drinčić, Polona Kogovšek, Arijana Filipić, Katja Fric, Barbara Simončič, Brigita Tomšič, Raghuraj S. Chouhan, Sivasambu Bohm, Suresh Kr. Verma, P.K. Panda, Ivan Jerman, 2023, izvirni znanstveni članek Povzetek: The outbreak of the Coronavirus disease 2019 (COVID-19) pandemic has highlighted the importance of developing antiviral surface coatings that are capable of repelling pathogens and neutralizing them through self-sanitizing properties. In this study, a novel coating design based on few-layer graphene (FLG) is proposed and silver-decorated micro copper flakes (CuMF) that exhibit both antibacterial and antiviral properties. The role of sacrificial anode surfaces and intrinsic graphene defects in enhancing the release of metal ions from CuMF embedded in water-based binders is investigated. In silico analysis is conducted to better understand the molecular interactions of pathogen-repelling species with bacterial or bacteriophage proteins. The results show that the optimal amount of CuMF/FLG in the coating leads to a significant reduction in bacterial growth, with reductions of 3.17 and 9.81 log for Staphylococcus aureus and Escherichia coli, respectively. The same coating also showed high antiviral efficacy, reducing bacteriophage phi6 by 5.53 log. The antiviral efficiency of the coating is find to be doubled compared to either micro copper flakes or few-layer graphene alone. This novel coating design is versatile and can be applied to various substrates, such as personal protective clothing and face masks, to provide biocidal activity against both bacterial and viral pathogens.
Ključne besede: antibacterial, antiviral, copper micro flakes, few-layer graphene, pathogen-repelling coating
Objavljeno v DiRROS: 16.12.2025; Ogledov: 10; Prenosov: 7
Celotno besedilo (2,95 MB)
Gradivo ima več datotek! Več... |
14. ʺHealthierʺ and ʺless heathyʺ classifications according to three nutrient profiling systems relative to nutrition and health claims on food labelsKatarina Debeljak, Igor Pravst, Katarina Košmelj, Milica Kač, 2015, izvirni znanstveni članek Ključne besede: živila, prehransko profiliranje, prehranske trditve, zdravstvene trditve, označbe živil, žita za zajtrk
Objavljeno v DiRROS: 16.12.2025; Ogledov: 13; Prenosov: 11
Celotno besedilo (723,16 KB)
Gradivo ima več datotek! Več... |
15. Testing whether a subgraph is convex or isometricSergio Cabello, 2025, objavljeni znanstveni prispevek na konferenci Povzetek: We consider the following two algorithmic problems: given a graph $G$ and a subgraph $H\subseteq G$, decide whether $H$ is an isometric or a geodesically convex subgraph of $G$. It is relatively easy to see that the problems can be solved by computing the distances between all pairs of vertices. We provide a conditional lower bound showing that, for sparse graphs with $n$ vertices and $\Theta(n)$ edges, we cannot expect to solve the problem in $O(n^{2-\varepsilon})$ time for any constant $\varepsilon>0$. We also show that the problem can be solved in subquadratic time for planar graphs and in near-linear time for graphs of bounded treewidth. Finally, we provide a near-linear time algorithm for the setting where $G$ is a plane graph and $H$ is defined by a few cycles in $G$.
Ključne besede: convex subgraphs, isometric subgraphs, plane graphs
Objavljeno v DiRROS: 16.12.2025; Ogledov: 7; Prenosov: 5
Celotno besedilo (1,08 MB)
Gradivo ima več datotek! Več... |
16. Ali plodova vinska mušica (Drosophila suzukii [Matsumura, 1931]) prefer-ira termotolerantno tujerodno kvasovko Hanseniaspora opuntiae Čadež, Poot, Raspor & M.Th. Smith pred avtohtono kvasovko H. uvarum (Nie-haus) Shehata, Mrak & Phaff ex M.Th. Smith?Klara Gajšek, Jaka Razinger, Neža Čadež, Eva Praprotnik, 2025, izvirni znanstveni članek Ključne besede: kvasovke, plodova vinska mušica, mutualizem, hlapne organske spojine, vedenjski poskusi, tujerodne kvasovke
Objavljeno v DiRROS: 16.12.2025; Ogledov: 8; Prenosov: 7
Celotno besedilo (674,08 KB)
Gradivo ima več datotek! Več... |
17. Recent advancements in the development of Two-Dimensional nanostructured based anode materials for stable power density in microbial fuel cellsRaghuraj S. Chouhan, Sonu Gandhi, Suresh Kr. Verma, Ivan Jerman, Syed Baker, Marko Štrok, 2023, pregledni znanstveni članek Povzetek: The demand for alternative energy sources from non-recyclable waste materials will be a hot research topic in future industries. This interest is primarily due to the ability to harness energy from waste materials, the provision of localized power solutions, and the promotion of efficient power conversation. In this respect, Microbial Fuel Cells (MFC) represent new energy sources possessing unique qualities for many applications. MFC generates power by utilising exoelectrogens forming the biofilm on the surface of the anode. Since in the MFC, wastewater is primarily converted into protons and electrons at the anode surface, where biofilms typically develop, the anode becomes the most vital component. Consequently, significant research has been conducted on anode material to improve MFC performance. The present review focuses on different aspects of the MFC, including a comprehensive summary of the recent developments in the field of MFCs, including a state-of-the-art literature review based on a bibliometric analysis using keywords, a description of the mechanism and operational principle of MFC, applications and a summary of current research perspectives including the use of carbon nanotubes, graphene, graphitic carbon nitride, MXene, and their nanocomposites as anode materials with stable power density performance. Lastly, we present the challenges and future perspectives regarding the continued development of MFC anode materials, culminating in overall conclusions related to MFC research.
Ključne besede: microbial fuel cells, 2D nanomaterial, power density, nanocomposite, Anode
Objavljeno v DiRROS: 16.12.2025; Ogledov: 13; Prenosov: 6
Celotno besedilo (13,94 MB)
Gradivo ima več datotek! Več... |
18. Stomach cancer elective surgery morbidity and mortality at 90-Day (Hold Study) : a prospective, international collaborative cohort studyClaudia Neves-Marques, Mohamed Abulazayem, Geoffrey Yuet Mun Wong, Ricardo David Maldonado, Yirupaiahgari Viswanath, Jan Grosek, Jurij Aleš Košir, 2026, izvirni znanstveni članek Povzetek: Background: Data on multinational 90-day mortality and morbidity rates after surgery for gastric cancer is limited in the literature. This study aimed to understand the 90-day mortality and morbidity outcomes among patients undergoing elective gastric cancer surgery, as in the GASTRODATA Registry, and to identify associated risk factors. Methods: We conducted an international prospective study on patients aged ≥ 18 years undergoing elective surgery for gastric cancer with curative intent from January 4 to September 30, 2022. Known metastatic disease, concurrent secondary cancers, gastrointestinal stromal tumour (GIST) and Siewert type I/II oesophagogastric junction malignancies were excluded. Univariate and multivariate logistic regression were used to identify variables associated with the 90-day outcome. Results: 380 collaborators from 47 countries submitted data on 1538 patients. Median age was 65 years (IQR: 19–94), and 58.5% were males. 90-day morbidity and mortality rates were 38.2% (n = 587) and 2.9% (n = 45), respectively. Pre-operative higher Charlson Comorbidity Index, higher ASA score, pre-operative weight loss > 10%, positive specimen margin, and post-operative pathological IV staging (p value < 0.05) were significantly associated with clinically relevant complications and mortality. Conclusion: Elective gastric cancer surgery has a 90-day morbidity of 38.2% and a 90-day mortality of 2.9% globally. This study provided the most comprehensive international 90-day prospective data to date regarding gastric cancer surgery. Several factors associated with higher morbidity were identified, highlighting the importance of a unified language on surgical morbidity, prehabilitation, and ongoing audits to enhance patient outcomes.
Ključne besede: gastric cancer, elective surgery, morbidity, mortality, 90-day postoperative outcomes, multinational audit, surgical complications, anastomotic leaks, patient safety
Objavljeno v DiRROS: 16.12.2025; Ogledov: 8; Prenosov: 7
Celotno besedilo (1,34 MB)
Gradivo ima več datotek! Več... |
19. Natural flavonoid pectolinarin computationally targeted as a promising drug candidate against SARS-CoV-2Mukta Rani, Raghuraj S. Chouhan, Rajesh K. Singh, 2024, izvirni znanstveni članek Povzetek: Coronavirus disease-2019 (COVID-19) has become a global pandemic, necessitating the development of new medicines. In this investigation, we identified potential natural flavonoids and compared their inhibitory activity against spike glycoprotein, which is a target of SARS-CoV-2 and SARS-CoV. The target site for the interaction of new inhibitors for the treatment of SARS-CoV-2 has 82% sequence identity and the remaining 18% dissimilarities in RBD S1-subunit, S2-subunit, and 2.5% others. Molecular docking was employed to analyse the various binding processes used by each ligand in a library of 85 natural flavonoids that act as anti-viral medications and FDA authorised treatments for COVID-19. In the binding pocket of the target active site, remdesivir has less binding interaction than pectolinarin, according to the docking analysis. Pectolinarin is a natural flavonoid isolated from Cirsiumsetidensas that has anti-cancer, vasorelaxant, anti-inflammatory, hepatoprotective, anti-diabetic, anti-microbial, and anti-oxidant properties. The S-glycoprotein RBD region (330–583) is inhibited by kaempferol, rhoifolin, and herbacetin, but the S2 subunit (686–1270) is inhibited by pectolinarin, morin, and remdesivir. MD simulation analysis of S-glycoprotein of SARS-CoV-2 with pectolinarin complex at 100ns based on high dock-score. Finally, ADMET analysis was used to validate the proposed compounds with the highest binding energy.
Ključne besede: coronaviruses, SARS-CoV-2, S-glycoproteins, computational analysis
Objavljeno v DiRROS: 16.12.2025; Ogledov: 12; Prenosov: 10
Celotno besedilo (5,57 MB)
Gradivo ima več datotek! Več... |
20. Child-parent cascade screening for familial hypercholesterolemia in Slovenia : insights from the pilot programJaka Šikonja, Kaja Kobale, Jan Kafol, Barbara Čugalj Kern, Matej Mlinarič, Ana Drole Torkar, Jernej Kovač, Matija Cevc, Zlatko Fras, Tadej Battelino, Urh Grošelj, 2025, izvirni znanstveni članek Povzetek: Background and aims: Cascade familial hypercholesterolemia (FH) screening of parents could reduce the burden cardiovascular disease (CVD) in relatives of index cases by enabling timely diagnosis of FH. Here, we present the positive outcomes of the pilot child-parent cascade screening program in Slovenia. Methods: One hundred and thirty-eight parents from 123 families of an index child with genetically confirmed FH were randomly included in the pilot child-parent cascade screening program. Index children were identified through the universal FH screening program in preschool children. Genetic testing using Sanger sequencing was performed for cascade screening to detect (likely) pathogenic variants, previously confirmed in the index child. Results: The success rate of confirming a (likely) pathogenic variant was 77.2 % when the first parent, preferably with higher total cholesterol levels, was tested, and reached 99.1 % when the variant was identified in the first tested parent or when both parents were tested. In the minority of cases (13.8 %), parents had had a clinical diagnosis of FH prior to their child and these had somewhat higher prevalence of CVD compared to parents that were diagnosed after their index child through the pilot program (12.5 % vs. 4.3 %; p = 0.382). Conclusions: In conclusion, the presented pilot child–parent cascade screening program is feasible in clinical practice and shows a high success rate in identifying parents with FH. Parents diagnosed through the program appeared to have a lower prevalence of CVD. However, larger cohorts are needed to confirm these findings.
Ključne besede: child-parent screening, cascade screening, familial hypercholesterolemia, cardiovascular disease, Slovenia
Objavljeno v DiRROS: 16.12.2025; Ogledov: 6; Prenosov: 7
Celotno besedilo (926,21 KB)
Gradivo ima več datotek! Več... |
