371. Trendi v gozdnem semenarstvu in drevesničarstvu v SlovenijiMarjana Westergren, Gregor Božič, Hojka Kraigher, 2017, drugi znanstveni članki Povzetek: Ob pričakovani večji pogostnosti in obsegu ujm sta nas žled februarja 2014 in namnožitev lubadarjev 2015 in 2016 opomnila na problematičnost preskrbe s semenom in sadikami. Pregledali smo obseg obnove s setvijo in sajenjem v zadnjih dvajsetih letih ter načrtovano porabo sadik in zaloge sadik v slovenskih drevesnicah. V Sloveniji se obseg obnove gozdov s sajenjem in setvijo zmanjšuje kljub vse večjim potrebam po obnovi gozdov po sanitarnih sečnjah; gozdno drevesničarstvo in semenarstvo razvojno zastaja. Trenutno v Sloveniji nismo sposobni zagotoviti zadostnih količin semena in sadik vseh ciljnih drevesnih vrst za potrebe sanacij v slovenskih gozdovih. Ključne besede: obnova gozdov, sadike, genetska pestrost, prilagodljivost, Slovenija Objavljeno v DiRROS: 11.05.2017; Ogledov: 4531; Prenosov: 955 Celotno besedilo (1,13 MB) |
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377. Comparative study of interactions of aliskiren and AT [sub] 1 receptor antagonists with lipid bilayersA. Sadegphour, Michael Rappolt, Dimitrios Ntountaniotis, Petros Chatzigeorgioug, Kyriakos Viras, Grigorios Megariotis, M. Papadopoulos, Eleni Siapi, Gregor Mali, Thomas Michael Mavromoustakos, 2015, izvirni znanstveni članek Povzetek: The renin-angiotensin-aldosterone system (RAAS) plays a key role in the regulation of blood pressure. Renin is the rate limiting enzyme of the RAAS and aliskiren is a highly potent and selective inhibitor of the human renin. Renin is known to be active both in the circulating blood stream as well as locally, when bound to the (pro)-renin receptor ((P)RR). In this study we have investigated a possible mechanism of action of aliskiren, in which its accumulation in the plasma membrane is considered as an essential step for effective inhibition. Aliskiren's interactions with model membranes (cholesterol rich and poor) have been investigated by applying different complementary techniques: differential scanning calorimetry (DSC), Raman spectroscopy, magic angle spinning (MAS) nuclear magnetic resonance (NMR) spectroscopy and small- and wide-angle X-ray scattering (SAXS and WAXS). In addition, in silico molecular dynamics (MD) calculations were applied for further confirmation of the experimental data. Aliskiren's thermal effects on the pre- and main transition of dipalmitoyl-phosphatidylcholine (DPPC) membranes as well as its topographical position in the bilayer show striking similarities to those of angiotens.in II type 1 receptor (AT1R) antagonists. Moreover, at higher cholesterol concentrations aliskiren gets expelled from the membrane just as it has been recently demonstrated for the angiotensin receptor blocker (ARB) losartan. Thus, we propose that both the AT1R and the (P)RR-bound renin active sites can be efficiently blocked by membrane-bound ARBs and aliskiren when cholesterol rich membrane rafts/caveolae are formed in the vicinity of the receptors. Ključne besede: aliskiren, renin, PRR, DPPC bilayers, raman spectroscopy, solid state NMR spectroscopy, SAXS and WAXS, MD simulations Objavljeno v DiRROS: 26.01.2015; Ogledov: 4377; Prenosov: 319 Povezava na datoteko |
378. Measurement of the electroweak production of dijets in association with a Z-boson and distributions sensitive to vector boson fusion in proton-proton collisions at [square root] s = 8 TeV using the ATLAS detectorG. Aad, Vladimir Cindro, Maksym Deliyergiyev, Andrej Filipčič, Saša Fratina, Andrej Gorišek, Borut Paul Kerševan, Gregor Kramberger, Boštjan Maček, Igor Mandić, Liza Mijović, Marko Mikuž, 2014, izvirni znanstveni članek Objavljeno v DiRROS: 24.11.2014; Ogledov: 3516; Prenosov: 0 |