1051. A coupled domain–boundary type meshless method for phase-field modelling of dendritic solidification with the fluid flowTadej Dobravec, Boštjan Mavrič, Rizwan Zahoor, Božidar Šarler, 2023, izvirni znanstveni članek Povzetek: Purpose - This study aims to simulate the dendritic growth in Stokes flow by iteratively coupling a domain and boundary type meshless method. Design/methodology/approach - A preconditioned phase-field model for dendritic solidification of a pure supercooled melt is solved by the strong-form space-time adaptive approach based on dynamic quadtree domain decomposition. The domain-type space discretisation relies on monomial augmented polyharmonic splines interpolation. The forward Euler scheme is used for time evolution. The boundary-type meshless method solves the Stokes flow around the dendrite based on the collocation of the moving and fixed flow boundaries with the regularised Stokes flow fundamental solution. Both approaches are iteratively coupled at the moving solid–liquid interface. The solution procedure ensures computationally efficient and accurate calculations. The novel approach is numerically implemented for a 2D case. Findings - The solution procedure reflects the advantages of both meshless methods. Domain one is not sensitive to the dendrite orientation and boundary one reduces the dimensionality of the flow field solution. The procedure results agree well with the reference results obtained by the classical numerical methods. Directions for selecting the appropriate free parameters which yield the highest accuracy and computational efficiency are presented. Originality/value - A combination of boundary- and domain-type meshless methods is used to simulate dendritic solidification with the influence of fluid flow efficiently.
Ključne besede: dendritic solidification, Stokes flow, phase-field method, space-time adaptivity, meshless methods, RBF-FD, modified method of regularised sources
Objavljeno v DiRROS: 07.02.2024; Ogledov: 312; Prenosov: 145
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1052. Oligomeric fragments distribution, structure and functionalities upon ruthenium-catalyzed technical lignin depolymerizationTina Ročnik, Erika Bartolomei, Anthony Dufour, Sébastien Leclerc, Philippe Arnoux, Blaž Likozar, Edita Jasiukaityte, Miha Grilc, Yann Le-Brech, 2024, izvirni znanstveni članek Objavljeno v DiRROS: 07.02.2024; Ogledov: 244; Prenosov: 145
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1053. Insights into microstructural evolution of tungsten-tungsten carbide plasma facing composite materials prepared by field assisted sintering techniqueAljaž Iveković, Matej Kocen, Petra Jenuš, Anže Abram, Črtomir Donik, Saša Novak, 2023, izvirni znanstveni članek Ključne besede: tungsten, tungsten carbide, interface, microstructure, fusion energy
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1054. In vitro evaluation of stress corrosion cracking susceptibility of PEO-coated rare-earth magnesium alloy WE43Julia Nachtsheim, Songyun Ma, Jaka Burja, Bernd Markert, 2024, izvirni znanstveni članek Ključne besede: stress corrosion cracking, PEO coating, biodegradable magnesium alloys, SCC test setup, in vitro experiments
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1055. Microstructure and properties variation of high-performance grey cast iron via small boron additionsGrega Klančnik, Jaka Burja, Urška Klančnik, Barbara Šetina, Luka Krajnc, Andrej Resnik, 2024, izvirni znanstveni članek Ključne besede: boron, cast iron, solidification, thermal analysis, Thermo-Calc
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1057. An outline of the history of radiotherapy at the Institute of oncology in Ljubljana from its beginning till 1980sAleksandra Oklješa Lukič, Karmen Hübscher, 2003, strokovni članek Povzetek: Background. The article presents the milestone events in the history of radiotherapy at the lnstitute of Oncology since its establishment till 1980s. It reviews the facts deduced from various jubilee publications, seminar reports and staff interviews of the Institute of Oncology. The aim of the article is to present the chronological history of radiotherapy at the Institute of Oncology, and to supplement the fragmented and incomplete recordswritten in the past. Conclusions. Available records are occasionally discrepant, but the most significant events in the history of the Institute ofOncology and its Radiotherapy Ward can nevertheless be ascertained.
Objavljeno v DiRROS: 06.02.2024; Ogledov: 215; Prenosov: 45
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1058. Experiencing professional strains of nurses, radiation engineers and physicians working at the Institute of oncology in LjubljanaAndreja Cirila Škufca Smrdel, 2003, izvirni znanstveni članek Povzetek: Background. Since 1974 the term burnout is used in psychology. Burnout describes the end result of stress and has been described by Maslach comprising three basic components: emotional exhaustion, depersonalization andlow personal accomplishment. In this paper we would like to describe some aspects of burnout experiences of the employees of the Institute of Oncology in Ljubljana. Subjects and methods. We used Questionnaire of professional stress, created by Zunter Nagy and Kocmur. In our research 137 health workers from four professional groups participated: physicians, graduated nurses, nurses and radiation engineers, representing 38% of all employees. Results. Wefound out that in the experience the professional stressof all four professional groups is relatively equalized. The most prominent feelings are of fatigue, irritability and work overload. There were no signs of depersonalization - as described by Maslach - reported in our group. In nursesand in radiation engineers a distress is significantly more often displayed due to poorer personal income and poorer material status. Nurses reported significantly more often the intention to change work position (51%),institution (57%) or job (47%). Conclusions. Workstress impacts on the experience and on the thought patterns in those participating in the study. Wecan describe those signs as burnout signs. However, there are more new questions opening in the future as well as the need to a longitudinal approachto the research of this more and more prominent field.
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1059. Detection of apoptotic cells in tumour paraffin sectionsJože Pižem, Andrej Cör, 2003, strokovni članek Povzetek: Apoptosis is a distinct form of cell death characterised by specific morphological features and regulated by complex molecular mechanisms. Its deregulation is fundamental for tumour growth and progression and, moreover, anticancer therapies suppress tumour growth mainly by induction of apoptosis. Since the extent of apoptosis in a tumour may have prognostic as well as therapeutic implications, much effort has been invested in developing specificmethods that can be routinely used to detect apoptotic cells in archival formalin fixed paraffin-embedded tissue. Complex molecular pathways are involved in the regulation of apoptosis. Pro-apoptotic signals trigger activation of caspases that specifically cleave target proteins. Cleavage of proteins (caspase substrates) is responsible for morphological changes of apoptotic cells and DNA fragmentation. In the last decade, detection of apoptotic cells in formalin fixed tumour tissue sections has been based mainlyon morphology and characteristic DNA fragmentation. Recently, specific antibodies to activated caspases and cleaved target proteins (including cytokeratin 18, actin and PARP) have been produced that enable accurate detection of apoptosis in paraffin sections.
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1060. Brain metastases in lung cancer : impact of prognostic factors on patient survivalUroš Smrdel, Matjaž Zwitter, Viljem Kovač, 2003, izvirni znanstveni članek Povzetek: Background. Brain metastases are common patterns of dissemination in lung cancer patients. In this paper we would like to assess the pattern of brain metastases in lung cancer patients and the impact of prognostic factors on thesurvival of lung cancer patients with brain metastases. Patients and methods. In the year 1998 there were 974 registered patients with lung cancer in Slovenia, six hundred and fifteen of them were treated at the Institute of Oncology Ljubljana and we analyzed them. Among 615 patients 137 (22.3%) of them have had brain metastases during a natural course of disease. Results. For 12 patients presenting with solitary brain metastases (most of them were undertaken metastaseetomy) median survival was 7.6 months, while in patients with multiple brain metastases the median survival was 2.8 months (p = 0.0018). Of the 137 patients 45 (32.8%) were small cell lung cancer patients, 43 (31.4%) were adenocarcinoma patients and 19 (13.9%) were squamous cell carcinoma patients. Patients with performance status (WHO scale) less than 2 had the median survival time 3.7 months while patients with performance status2 or more had median survival time 2.7 moths (p=0.0448). Conclusions. Patients with solitary brain metastases had better survival comparing with those who had multiple metastases. It is surprisingly that the portion of brain metastases patients with adenocarcinoma is almost equal to those with small-call lung cancer therefore, the prophylactic cranial radiation becomes actual for both groups of patients. The performance status of patients with brain metastases remains very important prognostic factor.
Objavljeno v DiRROS: 06.02.2024; Ogledov: 236; Prenosov: 67
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