1921. Insights into microstructural evolution of tungsten-tungsten carbide plasma facing composite materials prepared by field assisted sintering techniqueAljaž Iveković, Matej Kocen, Petra Jenuš, Anže Abram, Črtomir Donik, Saša Novak, 2023, izvirni znanstveni članek Ključne besede: tungsten, tungsten carbide, interface, microstructure, fusion energy Objavljeno v DiRROS: 07.02.2024; Ogledov: 324; Prenosov: 172 Celotno besedilo (14,95 MB) Gradivo ima več datotek! Več... |
1922. In vitro evaluation of stress corrosion cracking susceptibility of PEO-coated rare-earth magnesium alloy WE43Julia Nachtsheim, Songyun Ma, Jaka Burja, Bernd Markert, 2024, izvirni znanstveni članek Ključne besede: stress corrosion cracking, PEO coating, biodegradable magnesium alloys, SCC test setup, in vitro experiments Objavljeno v DiRROS: 07.02.2024; Ogledov: 343; Prenosov: 183 Celotno besedilo (16,00 MB) Gradivo ima več datotek! Več... |
1923. Microstructure and properties variation of high-performance grey cast iron via small boron additionsGrega Klančnik, Jaka Burja, Urška Klančnik, Barbara Šetina, Luka Krajnc, Andrej Resnik, 2024, izvirni znanstveni članek Ključne besede: boron, cast iron, solidification, thermal analysis, Thermo-Calc Objavljeno v DiRROS: 07.02.2024; Ogledov: 389; Prenosov: 173 Celotno besedilo (3,11 MB) Gradivo ima več datotek! Več... |
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1925. An outline of the history of radiotherapy at the Institute of oncology in Ljubljana from its beginning till 1980sAleksandra Oklješa Lukič, Karmen Hübscher, 2003, strokovni članek Povzetek: Background. The article presents the milestone events in the history of radiotherapy at the lnstitute of Oncology since its establishment till 1980s. It reviews the facts deduced from various jubilee publications, seminar reports and staff interviews of the Institute of Oncology. The aim of the article is to present the chronological history of radiotherapy at the Institute of Oncology, and to supplement the fragmented and incomplete recordswritten in the past. Conclusions. Available records are occasionally discrepant, but the most significant events in the history of the Institute ofOncology and its Radiotherapy Ward can nevertheless be ascertained. Objavljeno v DiRROS: 06.02.2024; Ogledov: 268; Prenosov: 49 Celotno besedilo (212,78 KB) |
1926. Experiencing professional strains of nurses, radiation engineers and physicians working at the Institute of oncology in LjubljanaAndreja Cirila Škufca Smrdel, 2003, izvirni znanstveni članek Povzetek: Background. Since 1974 the term burnout is used in psychology. Burnout describes the end result of stress and has been described by Maslach comprising three basic components: emotional exhaustion, depersonalization andlow personal accomplishment. In this paper we would like to describe some aspects of burnout experiences of the employees of the Institute of Oncology in Ljubljana. Subjects and methods. We used Questionnaire of professional stress, created by Zunter Nagy and Kocmur. In our research 137 health workers from four professional groups participated: physicians, graduated nurses, nurses and radiation engineers, representing 38% of all employees. Results. Wefound out that in the experience the professional stressof all four professional groups is relatively equalized. The most prominent feelings are of fatigue, irritability and work overload. There were no signs of depersonalization - as described by Maslach - reported in our group. In nursesand in radiation engineers a distress is significantly more often displayed due to poorer personal income and poorer material status. Nurses reported significantly more often the intention to change work position (51%),institution (57%) or job (47%). Conclusions. Workstress impacts on the experience and on the thought patterns in those participating in the study. Wecan describe those signs as burnout signs. However, there are more new questions opening in the future as well as the need to a longitudinal approachto the research of this more and more prominent field. Objavljeno v DiRROS: 06.02.2024; Ogledov: 329; Prenosov: 72 Celotno besedilo (125,41 KB) |
1927. Detection of apoptotic cells in tumour paraffin sectionsJože Pižem, Andrej Cör, 2003, strokovni članek Povzetek: Apoptosis is a distinct form of cell death characterised by specific morphological features and regulated by complex molecular mechanisms. Its deregulation is fundamental for tumour growth and progression and, moreover, anticancer therapies suppress tumour growth mainly by induction of apoptosis. Since the extent of apoptosis in a tumour may have prognostic as well as therapeutic implications, much effort has been invested in developing specificmethods that can be routinely used to detect apoptotic cells in archival formalin fixed paraffin-embedded tissue. Complex molecular pathways are involved in the regulation of apoptosis. Pro-apoptotic signals trigger activation of caspases that specifically cleave target proteins. Cleavage of proteins (caspase substrates) is responsible for morphological changes of apoptotic cells and DNA fragmentation. In the last decade, detection of apoptotic cells in formalin fixed tumour tissue sections has been based mainlyon morphology and characteristic DNA fragmentation. Recently, specific antibodies to activated caspases and cleaved target proteins (including cytokeratin 18, actin and PARP) have been produced that enable accurate detection of apoptosis in paraffin sections. Objavljeno v DiRROS: 06.02.2024; Ogledov: 325; Prenosov: 75 Celotno besedilo (170,01 KB) |
1928. Brain metastases in lung cancer : impact of prognostic factors on patient survivalUroš Smrdel, Matjaž Zwitter, Viljem Kovač, 2003, izvirni znanstveni članek Povzetek: Background. Brain metastases are common patterns of dissemination in lung cancer patients. In this paper we would like to assess the pattern of brain metastases in lung cancer patients and the impact of prognostic factors on thesurvival of lung cancer patients with brain metastases. Patients and methods. In the year 1998 there were 974 registered patients with lung cancer in Slovenia, six hundred and fifteen of them were treated at the Institute of Oncology Ljubljana and we analyzed them. Among 615 patients 137 (22.3%) of them have had brain metastases during a natural course of disease. Results. For 12 patients presenting with solitary brain metastases (most of them were undertaken metastaseetomy) median survival was 7.6 months, while in patients with multiple brain metastases the median survival was 2.8 months (p = 0.0018). Of the 137 patients 45 (32.8%) were small cell lung cancer patients, 43 (31.4%) were adenocarcinoma patients and 19 (13.9%) were squamous cell carcinoma patients. Patients with performance status (WHO scale) less than 2 had the median survival time 3.7 months while patients with performance status2 or more had median survival time 2.7 moths (p=0.0448). Conclusions. Patients with solitary brain metastases had better survival comparing with those who had multiple metastases. It is surprisingly that the portion of brain metastases patients with adenocarcinoma is almost equal to those with small-call lung cancer therefore, the prophylactic cranial radiation becomes actual for both groups of patients. The performance status of patients with brain metastases remains very important prognostic factor. Objavljeno v DiRROS: 06.02.2024; Ogledov: 277; Prenosov: 74 Celotno besedilo (98,88 KB) |
1929. Survivin - an inhibitor of apoptosis and a new therapeutic target in cancerJože Pižem, Andrej Cör, 2003, strokovni članek Povzetek: Survivin is a unique member of the inhibitor of apoptosis (IAP) protein family. It inhibits apoptosis by interfering with post-mitochondrial events during apoptosis, thus blocking activation of caspases. The expression of survivin is among the most tumour specific of all human genes. It is overexpressed in most human cancers but is not detected in most normal tissues. Some molecular mechanisms of survivin upregulation in cancer have been elucidated, including loss of the wild-type p53. Tumours that overexpresssurvivin generally bear a worse prognosis and are associated with resistance to therapy. Its differential expression in caneer versus normal tissues makes survivin detection a useful tool in cancer diagnostics and a promising therapeutic target. Survivin targeting has resulted in increased spontaneous and induced apoptosis and inhibition of tumourgrowth. Some anticaneer drugs currently introduced into clinical practice might well act byinactivaring survivin. Objavljeno v DiRROS: 06.02.2024; Ogledov: 311; Prenosov: 68 Celotno besedilo (185,35 KB) |
1930. The role of cyclooxygenase-2 in the malignant tissue and possible applicability of cyclooxygenase-2 inhibitors in the therapy of cancerMateja Legan, 2003, pregledni znanstveni članek Povzetek: Cyclooxygenase-2 (COX 2), an inducible prostaglandin (PG) synthase, is elevated in many types of malignant and pre-malignant tissues. This enzyme is localized in neoplastic (epithelial) cells, microvascular endothelial cells, and stromal fibroblasts. Through the released PG it enhances carcinogenesis with increasing angiogenesis, inhibiting apoptosis, activating matrix metalloproteinases, suppressing of cell mediated antitumor immune response andprotection against damage by cytotoxic agents. Evidences from in vitro studies, studies on animal models as well as first clinical outcomes suggest that the inhibition of COX 2 may suppress carcinogenesis by affecting a numberof pathways: inhibiting angiogenesis, invasiveness of tumors and promoting apoptosis. References forecast that COX 2 inhibitors, mostly COX 2 selective inhibitors, may get a role in the therapy of cancer as an adjuvant therapy or as an co-chemotherapeutic agent. The purpose of the present articleis to summarize the most important facts about the role of COX 2 in themalignant tissue and discuss possible ways for potential therapeutic place of COX 2 inhibitors in clinical practice. Objavljeno v DiRROS: 06.02.2024; Ogledov: 278; Prenosov: 76 Celotno besedilo (205,37 KB) |