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111.
Noninvasive ventilation : education and training. A narrative analysis and an international consensus document
Habib Mohammad Reazaul Karim, Karen E. A. Burns, Laura D. Ciobanu, Mohamad F. El-Khatib, Antonello Nicolini, Nicola Vargas, Thierry Hernández-Gilsoul, Szymon Skoczyński, Vito Antonio Falcone, Jean-Michel Arnal, Irena Šarc, 2019, izvirni znanstveni članek

Povzetek: Noninvasive ventilation (NIV) is an increasingly used method of respiratory support. The use of NIV is expanding over the time and if properly applied, it can save patients’ lives and improve long-term prognosis. However, both knowledge and skills of its proper use as life support are paramount. This systematic review aimed to assess the importance of NIV education and training. Literature search was conducted (MEDLINE: 1990 to June, 2018) to identify randomized controlled studies and systematic reviews with the results analyzed by a team of experts across the world through e-mail based communications. Clinical trials examining the impact of education and training in NIV as the primary objective was not found. A few studies with indirect evidence, a simulation-based training study, and narrative reviews were identified. Currently organized training in NIV is implemented only in a few developed countries. Due to a lack of high-grade experimental evidence, an international consensus on NIV education and training based on opinions from 64 experts across the twenty-one different countries of the world was formulated. Education and training have the potential to increase knowledge and skills of the clinical staff who deliver medical care using NIV. There is a genuine need to develop structured, organized NIV education and training programs, especially for the developing countries.
Ključne besede: noninvasive ventilation -- education, health personnel -- education, training, staff
Objavljeno v DiRROS: 22.10.2020; Ogledov: 1359; Prenosov: 904
.pdf Celotno besedilo (258,13 KB)
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112.
CD3+CD4-CD8- mucosal T cells are associated with uncontrolled chronic rhinosinusitis with nasal polyps
Tanja Soklič, Mira Šilar, Matija Rijavec, Ana Koren, Izidor Kern, Irena Hočevar-Boltežar, Peter Korošec, 2019, drugi znanstveni članki

Povzetek: Increased mucosal double-negative (DN) CD3+CD4-CD8- T cells were found for the first time in CRS and were much more abundant in uncontrolled CRSwNP than in well-controlled CRSwNP.
Ključne besede: chronic rhinosinusitis, CD3+ T-cells, CD4- T-cells, CD8- T-cells
Objavljeno v DiRROS: 22.10.2020; Ogledov: 1618; Prenosov: 526
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113.
Prevalence of and factors associated with healthcare-associated infections in Slovenian acute care hospitals : results of the third national survey
Irena Klavs, Mojca Serdt, Aleš Korošec, Tatjana Lejko-Zupanc, Blaž Pečavar, 2019, izvirni znanstveni članek

Povzetek: Introduction. In the third Slovenian national healthcare-associated infections (HAIs) prevalence survey, conducted within the European point prevalence survey of HAIs and antimicrobial use in acute care hospitals, we estimated the prevalence of all types of HAIs and identified factors associated with them. Methods. Patients were enrolled into a one-day cross-sectional study in November 2017. Descriptive analyses were performed to describe the characteristics of patients, their exposure to invasive procedures and the prevalence of different types of HAIs. Univariate and multivariate analyses of association of having at least one HAI with possible risk factors were performed to identify risk factors. Results. Among 5,743 patients, 4.4% had at least one HAI and an additional 2.2% were still treated for HAIs on the day of the survey, with a prevalence of HAIs of 6.6%. The prevalence of pneumoniae was the highest (1.8%), followed by surgical site infections (1.5%) and urinary tract infections (1.2%). Prevalence of blood stream infections was 0.3%. In intensive care units (ICUs), the prevalence of patients with at least one HAI was 30.6%. Factors associated with HAIs included central vascular catheter (adjusted odds ratio [aOR] 4.1; 95% confidence intervals [CI]: 3.1–5.4), peripheral vascular catheter (aOR 3.0; 95% CI: 2.3–3.9), urinary catheter (aOR 1.8; 95% CI: 1.4–2.3). Conclusions. The prevalence of HAIs in Slovenian acute care hospitals in 2017 was substantial, especially in ICUs. HAIs prevention and control is an important public health priority. National surveillance of HAIs in ICUs should be developed to support evidence-based prevention and control.
Ključne besede: healthcare-associated infections, prevalence, survey, risk factors, Slovenia
Objavljeno v DiRROS: 16.10.2020; Ogledov: 2463; Prenosov: 908
.pdf Celotno besedilo (255,15 KB)
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114.
Transcription factors gene expression in chronic rhinosinusitis with and without nasal polyps
Tanja Soklič, Matija Rijavec, Mira Šilar, Ana Koren, Izidor Kern, Irena Hočevar-Boltežar, Peter Korošec, 2019, izvirni znanstveni članek

Povzetek: Background. Chronic rhinosinusitis (CRS) current therapeutic approaches still fail in some patients with severe persistent symptoms and recurrences after surgery. We aimed to evaluate the master transcription factors gene expression levels of T cell subtypes in chronic rhinosinusitis with nasal polyps (CRSwNP) and chronic rhinosinusitis without nasal polyps (CRSsNP) that could represent new, up-stream targets for topical DNAzyme treatment. Patients and methods. Twenty-two newly diagnosed CRS patients (14 CRSwNP and 8 CRSsNP) were prospectively biopsied and examined histopathologically. Gene expression levels of T-box transcription factor (T-bet, TBX21), GATA binding protein 3 (GATA3), Retinoic acid-related orphan receptor C (RORC) and Forkhead box P3 (FOXP3) were analyzed by real-time quantitative polymerase chain reaction (RT-qPCR). Results. Eosinophilic CRSwNP was characterized by higher level of GATA3 gene expression compared to noneosinophilic CRSwNP, whereas there was no difference in T-bet, RORC and FOXP3 between eosinophilic and noneosinophilic CRSwNP. In CRSsNP, we found simultaneous upregulation of T-bet, GATA3 and RORC gene expression levels in comparison to CRSwNP; meanwhile, there was no difference in FOXP3 gene expression between CRSwNP and CRSsNP. Conclusions. In eosinophilic CRSwNP, we confirmed the type 2 inflammation by elevated GATA3 gene expression level. In CRSsNP, we unexpectedly found simultaneous upregulation of T-bet and GATA3 that is currently unexplained; however, it might originate from activated CD8+ cells, abundant in nasal mucosa of CRSsNP patients. The elevated RORC in CRSsNP could be part of homeostatic nasal immune response that might be better preserved in CRSsNP patients compared to CRSwNP patients. Further data on transcription factors expression rates in CRS phenotypes are needed.
Ključne besede: sinusitis, nasal polyps, Th1 cells, Th2 cells, Th17 cells, transcription factors, chronic rhinosinusitis
Objavljeno v DiRROS: 09.10.2020; Ogledov: 1544; Prenosov: 836
.pdf Celotno besedilo (698,54 KB)
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115.
116.
Outbreak of human metapneumovirus infection in zoo, Slovenia
Tina Uršič, Nika Lalek, Pavel Kvapil, Marjan Kastelic, Vasilij Cociancich, Irena Grmek-Košnik, Miroslav Petrovec, 2020, drugi znanstveni članki

Ključne besede: metapneumovirus, infection diseases, zoo
Objavljeno v DiRROS: 11.09.2020; Ogledov: 1386; Prenosov: 737
.pdf Celotno besedilo (383,14 KB)
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117.
Non-invasive ventilation in patients with an altered level of consciousness : a clinical review and practical insights
Gil Gonçalves, Haitham Saeed, Mohamed E Abdelrahim, Hadeer S Harb, Yasmin M Madney, Kevin Eng, Habib Mohammad Reazaul Karim, Mohamad F. El-Khatib, Bushra Mina, Szymon Skoczyński, Irena Šarc, 2020, pregledni znanstveni članek

Povzetek: Non-invasive ventilation has gained an increasingly pivotal role in the treatment of acute hypoxemic and/or hypercapnic respiratory failure and offers multiple advantages over invasive mechanical ventilation. Some of these advantages include the preservation of airway defense mechanisms, a reduced need for sedation, and an avoidance of complications related to endotracheal intubation. Despite its advantages, non-invasive ventilation has some contraindications that include, among them, severe encephalopathy. In this review article, the rationale, evidence, and drawbacks of the use of noninvasive ventilation in the context of hypercapnic and non-hypercapnic patients with an altered level of consciousness are analyzed.
Ključne besede: noninvasive ventilation, brain diseases, consciousness disorders, coma, altered consciousness, encephalopathy
Objavljeno v DiRROS: 09.09.2020; Ogledov: 1381; Prenosov: 780
.pdf Celotno besedilo (375,01 KB)
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118.
Socialna problematika onkoloških bolnikov in pravice s področja zdravstvenega,pokojninskega in invalidskega zavarovanja
Irena Golob, 2000, samostojni strokovni sestavek ali poglavje v monografski publikaciji

Objavljeno v DiRROS: 28.08.2020; Ogledov: 1003; Prenosov: 249
.pdf Celotno besedilo (819,49 KB)

119.
Continuous positive airway pressure in non-apneic asthma : a clinical review of the current evidence
Habib Mohammad Reazaul Karim, Antonio M. Esquinas, Sally Ziatabar, Giuseppe Insalaco, Szymon Skoczyński, Irena Šarc, Luigi Ferini-Strambi, Leyla Pur Ozyigit, Thierry Hernández-Gilsoul, Subrata Kumar Singha, 2020, pregledni znanstveni članek

Povzetek: The use of continuous positive airway pressure (CPAP) in the asthma has been a question of debate over the past several years. Various studies, including animal and human studies have attempted to understand the role and pathophysiology of CPAP in patients with either well controlled or poorly controlled asthma. The aim of this manuscript is to review the current available literature on the physiologic and clinical effects of CPAP in animal models of asthma and humans with stable asthma.
Ključne besede: asthma, bronchoconstriction, continuous positive airway pressure, CPAP
Objavljeno v DiRROS: 10.08.2020; Ogledov: 1432; Prenosov: 406
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120.
Rak trebušne slinavke : kaj morate vedeti o bolezni?
Janja Ocvirk, Martina Reberšek, Zvezdana Hlebanja, Erik Škof, Irena Oblak, Vaneja Velenik, Franc Anderluh, 2008, slovar, enciklopedija, leksikon, priročnik, atlas, zemljevid

Ključne besede: dejavniki tveganja, simptomi, diagnostika, zdravljenje, bolečina
Objavljeno v DiRROS: 10.08.2020; Ogledov: 1765; Prenosov: 695
.pdf Celotno besedilo (1,52 MB)

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