1. Sequestration of membrane cholesterol by cholesterol-binding proteins inhibits SARS-CoV-2 entry into Vero E6 cellsMagdalena Kulma, Aleksandra Šakanović, Apolonija Bedina Zavec, Simon Caserman, Neža Omersa, Gašper Šolinc, Sara Orehek, Iva Hafner Bratkovič, Urška Kuhar, Brigita Slavec, Uroš Krapež, Matjaž Ocepek, Toshihide Kobayashi, Katarzyna Kwiatkowska, Roman Jerala, Marjetka Podobnik, Gregor Anderluh, 2024, izvirni znanstveni članek Objavljeno v DiRROS: 05.08.2024; Ogledov: 77; Prenosov: 62
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2. Structural basis for the multitasking nature of the potato virus Y coat proteinAndreja Kežar, Luka Kavčič, Martin Pólak, Jiři Nováček, Ion Gutiérrez-Aguirre, Magda Tušek-Žnidarič, Anna Coll Rius, Katja Stare, Kristina Gruden, Maja Ravnikar, David Pahovnik, Ema Žagar, Franci Merzel, Gregor Anderluh, Marjetka Podobnik, 2019, izvirni znanstveni članek Povzetek: Potato virus Y (PVY) is among the most economically important plant pathogens. Using cryoelectron microscopy, we determined the near-atomic structure of PVY’s flexuous virions, revealing a previously unknown lumenal interplay between extended carboxyl-terminal regions of the coat protein units and viral RNA. RNA–coat protein interactions are crucial for the helical configuration and stability of the virion, as revealed by the unique near-atomic structure of RNA-free virus-like particles. The structures offer the first evidence for plasticity of the coat protein’s amino- and carboxyl-terminal regions. Together with mutational analysis and in planta experiments, we show their crucial role in PVY infectivity and explain the ability of the coat protein to perform multiple biological tasks. Moreover, the high modularity of PVY virus-like particles suggests their potential as a new molecular scaffold for nanobiotechnological applications.
Ključne besede: plant pathogens, potato virus Y, viral RNA
Objavljeno v DiRROS: 23.07.2024; Ogledov: 125; Prenosov: 117
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6. Pore-forming moss protein bryoporin is structurally and mechanistically related to actinoporins from evolutionarily distant cnidariansGašper Šolinc, Tomaž Švigelj, Neža Omersa, Tina Snoj, Katja Pirc, Nada Žnidaršič, Akiko Yamaji-Hasegawa, Toshihide Kobayashi, Gregor Anderluh, Marjetka Podobnik, 2022, izvirni znanstveni članek Objavljeno v DiRROS: 11.10.2022; Ogledov: 641; Prenosov: 430
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9. Selective inhibition of NLRP3 inflammasome by designed peptide originating from ASCPetra Sušjan, Duško Lainšček, Žiga Strmšek, Vesna Hodnik, Gregor Anderluh, Iva Hafner Bratkovič, 2020, izvirni znanstveni članek Ključne besede: blood-brain barrier, inflammation, ▫$IL-1beta$▫, peptide inhibitors
Objavljeno v DiRROS: 24.03.2022; Ogledov: 840; Prenosov: 529
Celotno besedilo (3,68 MB)
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10. Design of protein logic gate system operating on lipid membranesNeža Omersa, Saša Rezelj, Matic Kisovec, Marjetka Podobnik, Gregor Anderluh, 2020, izvirni znanstveni članek Ključne besede: pore-forming toxin, listeriolysin O, protein logic gates, lipid membrane, DARPin, pH
Objavljeno v DiRROS: 25.11.2020; Ogledov: 1737; Prenosov: 956
Celotno besedilo (4,48 MB)
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