1. Interval cancers after negative immunochemical test compared to screen and non-respondersʼ detected cancers in Slovenian colorectal cancer screening programmeDominika Novak-Mlakar, Tatjana Kofol-Bric, Ana Lucija Škrjanec, Mateja Krajc, 2018, izvirni znanstveni članek Povzetek: We assessed the incidence and characteristics of interval cancers after faecal immunochemical occult blood test and calculated the test sensitivity in Slovenian colorectal cancer screening programme. Patients and methods. The analysis included the population aged between 50 to 69 years, which was invited for screening between April 2011 and December 2012. The persons were followed-up until the next foreseen invitation, in average for 2 years. The data on interval cancers and cancers in non-responders were obtained from cancer registry. Gender, age, years of schooling, the cancer site and stage were compared among three observed groups. We used the proportional incidence method to calculate the screening test sensitivity. Results. Among 502,488 persons invited for screening, 493 cancers were detected after positive screening test, 79 interval cancers after negative faecal immunochemical test and 395 in non-responders. The proportion of interval cancers was 13.8%. Among the three observed groups cancers were more frequent in men (p = 0.009) and in persons aged 60+ years (p < 0.001). Comparing screen detected and cancers in non-responders with interval cancers more interval cancers were detected in persons with 10 years of schooling or more (p = 0.029 and p = 0.001), in stage III (p = 0.027) and IV (p < 0.001), and in right hemicolon (p < 0.001). Interval cancers were more frequently in stage I than non-responders cancers (p = 0.004). Test sensitivity of faecal immunochemical test was 88.45%. Conclusions. Interval cancers in Slovenian screening programme were detected in expected proportions as in similar programmes. Test sensitivity was among the highest when compared to similar programmes and was accomplished using test kit for two stool samples.
Ključne besede: cancer screening, colorectal cancer, faecal immunochemical test, test sensitivity
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2. Presejanje za raka debelega črevesa in danke pri asimptomatski populaciji v starosti 50 do 69 letDominika Novak-Mlakar, Jožica Maučec Zakotnik, 2006, ni določena Povzetek: Izhodišča. Pojavnost raka debelega črevesa in danke je v zadnjih desetletjih v razvitih deželah v porastu. V Sloveniji predstavlja drugi najpogostejši vzrok smrti zaradi raka. Po podatkih Registra raka je bila leta 2002 incidenca pri moških 68,5/100.000 prebivalcev, pri ženskah 49,8/100.000. Kljub vzpodbudnemu dejstvu, da se relativno 5-letno preživetje bolnikov s to boleznijo v zadnjem obdobju daljša, odkrijemo še vedno mnogo bolnikov, ko je bolezen že v napredovalem stadiju, z lokalnimi in oddaljenimi zasevki in je prognoza ter preživetje kljub kombiniranim oblikam zdravljenja slaba. Bolezen je ozdravljiva le, če jo ugotovimo in kirurško odstranimo v zgodnji razvojni stopnji. Zaključki. Rak črevesa predstavlja ozdravljivo bolezen, če preprečimo njeno preobrazbo iz premalignih adenomov ali ga odkrijemo in kirurško odstranimo v lokalno omejeni obliki. Za dolgoročen uspeh bo potrebna primerna ozaveščenost prebivalstva in udejanjanje priporočil.
Ključne besede: rak (medicina), debelo črevo, danka, novotvorbe, diagnostika, preprečevanje, Slovenija, presejalni testi
Objavljeno v DiRROS: 05.12.2023; Ogledov: 281; Prenosov: 93
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4. Zdrava izbira - organizirana presejanja za raka v SlovenijiKatja Jarm, Dominika Novak-Mlakar, Urška Ivanuš, Tatjana Kofol-Bric, Ana Šinkovec, Mojca Florjančič, Kaja Batista, 2021, objavljeni strokovni prispevek na konferenci Ključne besede: presejalni programi, preventivni programi, onkologija, javno zdravje
Objavljeno v DiRROS: 17.12.2021; Ogledov: 898; Prenosov: 307
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10. Program SVIT - presejanje za raka na debelem črevesu in dankiDominika Novak-Mlakar, Tatjana Kofol-Bric, Jožica Maučec Zakotnik, 2015, objavljeni strokovni prispevek na konferenci Ključne besede: NIJZ, SVIT, rak, onkologija, debelo črevo, danka
Objavljeno v DiRROS: 17.09.2019; Ogledov: 2101; Prenosov: 655
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