71. ElectroKitty : a Python tool for modeling electrochemical data including non-langmuir adsorptionOžbej Vodeb, Pedro Farinazzo Bergamo Dias Martins, Dušan Strmčnik, Nejc Hodnik, Miran Gaberšček, 2025, drugi znanstveni članki Ključne besede: electrochemistry, computer modelling, simulation, electrochemistry voltammetry, data analysis
Objavljeno v DiRROS: 12.12.2025; Ogledov: 65; Prenosov: 35
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72. Influence of near-surface helium on the deuterium retention and uptake in tungstenSabina Markelj, Thomas Schwarz-Selinger, Andreja Šestan, Janez Zavašnik, Mitja Kelemen, 2025, izvirni znanstveni članek Povzetek: The effect of near-surface helium (He) on deuterium (D) retention and uptake into the bulk of tungsten (W) was investigated. To quantify the He influence on D uptake, He was implanted close to the surface with 3 keV energy at different fluences and different temperatures. 20 MeV W irradiation was performed at room temperature after He implantation to create defects within the first 2.3 µm. Samples were then exposed to a low flux, low energy (300 eV/D) D ion beam at 450 K. The defects created by W ions trap penetrating D and make it hence possible to quantify D transport into depth below the He layer using 3He nuclear reaction analysis. Elastic recoil detection analysis enabled us to measure the D and He concentration depth profiles near the surface. Results show that D gets preferentially retained where He is implanted with D concentrations up to 10 at.%. At the same time D uptake beyond the He zone is reduced by a factor of 15 compared to a He-free W sample.
Ključne besede: deuterium retention, displacement damage
Objavljeno v DiRROS: 11.12.2025; Ogledov: 98; Prenosov: 52
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74. Microstructural analysis of tungsten single crystals irradiated by MeV W ions : the effect of irradiation dose and temperatureJanez Zavašnik, Andreja Šestan, Thomas Schwarz-Selinger, Esther Punzón Quijorna, Mitja Kelemen, Jan Predrag, Sabina Markelj, 2025, izvirni znanstveni članek Povzetek: We investigated the microstructural evolution of W(111) single crystals under high-energy self-ion irradiation at 290 K and 800 K, using complementary characterization techniques, including Scanning electron microscopy (SEM), Transmission electron microscopy (TEM), Rutherford backscattering spectrometry in channelling regime (RBS-C), Positron annihilation spectroscopy (PAS), and Nuclear reaction analysis (NRA). Irradiation with MeV W ions allowed for controlled defect formation, with dose and temperature significantly affecting defect type and distribution. At 290 K, interstitial defects evolved from dislocation loops at low doses (0.02 dpa) to dislocation networks at higher doses (0.2 dpa). In contrast, at 800 K, lower dislocation densities were observed, with nm-sized dots and isolated lines forming at 0.02 dpa and developing into longer dislocation lines (~30 nm) at 0.2 dpa. RBS-C spectra support these findings, showing a trend of increasing dislocation density with dose but decreasing with temperature. PAS analyses revealed mono-vacancies and small vacancy clusters (V2–V4) at 290 K, coalescing into larger clusters (V25–V50) at 800 K. NRA measurements indicated greater deuterium retention at 290 K than at 800 K, consistent with lower vacancy mobility at the lower temperature. Combined TEM, RBS-C, PAS, and NRA observations highlight increased vacancy mobility and defect recombination with temperature, forming larger vacancy clusters at 800 K. This comprehensive study provides quantitative insights into defect formation and evolution in W single crystals, presenting a comparative analysis of defect distributions across multiple techniques and revealing temperature-dependent mechanisms of microstructural change.
Ključne besede: heavy-ion irradiation, structural defects
Objavljeno v DiRROS: 11.12.2025; Ogledov: 101; Prenosov: 71
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75. Universal screening for familial hypercholesterolemia in preschool children and their families in Slovenia (FH-FAMILIES) : a protocol for a study of four-stage screening programMia Becker, Bernarda Vogrin, Jan Kafol, Barbara Čugalj Kern, Urh Grošelj, 2025, izvirni znanstveni članek Povzetek: Familial hypercholesterolemia (FH) is the most common metabolic disease, with prevalence estimated between 1:250 and 1:300. The affected individuals have a significantly higher risk for developing atherosclerosis and cardiovascular disease (CVD) compared to non-affected individuals. Early CVD can be prevented with early detection and treatment of FH. In Slovenia we have been conducting a national three-staged program of universal screening for FH of preschoolers. Goals: Our goal is to collect data for 5000 children, which is approximately one-quarter of one generation of preschoolers for the year 2023 (n = 5000). Methods: Our study includes both prospective and retrospective components and is a non-interventional cohort study. The prospective component began in 2023, when a questionnaire was distributed to multiple community health centers and outpatient practices in Slovenia. Pediatricians or school medicine specialists completed these questionnaires. The retrospective component involves our research team collecting the remaining necessary data from existing medical records. We are going to follow our algorithm for the implementation of the universal cholesterol screening program and seek all children that will be referred to the Pediatric Lipid Clinic at the University Children’s Hospital, University Medical Centre (UCH-UMC), Ljubljana, for further genetic testing. If a child has a positive genetic result, their parents and siblings will undergo genetic testing. Conclusions: Despite being a common genetic disorder, familial hypercholesterolemia (FH) is still largely underdiagnosed globally; fewer than 10% of affected individuals are thought to be identified. Early detection through effective screening is therefore essential to improve outcomes and prevent premature cardiovascular events.
Ključne besede: hypercholesterolemia, universal screening, preschoolers, total cholesterol, genetic testing
Objavljeno v DiRROS: 11.12.2025; Ogledov: 102; Prenosov: 36
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76. L-FABP as a potential biomolecular marker of liver graft injuryAna Kalamutova, Danaja Plevel, Mihajlo Djokić, Aleš Jerin, Blaž Trotovšek, Miha Petrič, 2025, izvirni znanstveni članek Povzetek: Background: In recent years, indications for liver transplantation have expanded, while the age of transplant recipients has significantly increased due to improvements in perioperative management. As clinical manifestations of posttransplant complications vary and are often nonspecific, the identification of appropriate biomarkers is important for the assessment of graft quality and early recognition of potential complications following liver transplantation. Liver-type FABP (L-FABP) is a small cytoplasmic protein found abundantly in hepatocytes and is involved in the intracellular transport of long-chain fatty acids. Elevated serum levels have been detected in acute and chronic liver failure, kidney failure, and some malignancies. Materials and Methods: We conducted a prospective, single-center study from July 2023 to January 2025, including 29 adult patients who underwent deceased-donor transplantation. Three patients were excluded due to inadequate sample withdrawals. Serum L-FABP was measured preoperatively and on postoperative days 1, 3, 5, 7, and 14. Clinical, surgical, and biochemical data were collected and analyzed using non-parametric statistical tests. Results: L-FABP levels were significantly higher on POD 7 in recipients of grafts from donors ≥ 65 years (p = 0.035), with no corresponding changes in standard liver function markers. While no significant differences in L-FABP levels were found between patients with and without infectious biliary or vascular complications (all p > 0.05), we proved a strong negative correlation between intraoperative blood transfusion volume and L-FABP levels on POD 5 (ρ = −0.677, p < 0.001) and POD 7 (ρ = −0.455, p = 0.025). Conclusions: Our findings suggest that L-FABP holds promise as a biomarker for the early detection of subclinical hepatic graft cellular injury, which is not detected by means of conventional biomarkers for liver function.
Ključne besede: liver transplantation, biomarker, L-FABP, hepatic graft injury, marginal liver graft
Objavljeno v DiRROS: 11.12.2025; Ogledov: 93; Prenosov: 43
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77. Palliative care for children and adults with inherited metabolic disease in Europe : an underutilised service for supportive treatment and careAnja Lee, Yngve Thomas Bliksrud, Michela Onali, Julia Neugebauer, Francois Eyskens, 2025, izvirni znanstveni članek Povzetek: Palliative care should be an integral part of follow-up for patients with life-limiting/life-threatening conditions, irrespective of age and diagnosis. Many patients with inherited metabolic disorders (IMD) have palliative care needs due to multi-systemic conditions without curative treatment options. To map the organisation and accessibility of palliative care across European IMD expert centres, and to explore the experiences of IMD physicians with palliative care, the European Reference Network for Hereditary Metabolic Disorders (MetabERN) invited physicians from all 103 member institutions to participate in a survey covering various aspects of palliative care. Ninety-two physicians from 63 institutions in 23 countries participated. A national plan or strategy for palliative care had been established in most countries (87%). Both children (91%) and adults (89%) had access to palliative care services. Most paediatric (86%) and many adult IMD physicians (67%) used advance care planning. A total of 284 referrals to palliative care were reported, mostly IMD patients with lysosomal and mitochondrial disorders, and neurological, respiratory, cognitive and gastrointestinal comorbidities. However, during the past 5 years, the majority of physicians (60%) had referred 20% or fewer of their deceased patients to palliative care. Although palliative care is available in most European IMD expert centres, only a small proportion of deceased IMD patients has been referred. The findings of this study indicate both a misconception and underutilisation of modern palliative care services. Addressing existing barriers is essential, and both IMD physicians and patients may need more information about available palliative care services and up-to-date indications for referral.
Ključne besede: palliative care, quality of life, patients, paediatric palliative care, inherited metabolic diseases, genetic disorders, MetabERN, The European Reference Network for Hereditary Metabolic Disorders
Objavljeno v DiRROS: 11.12.2025; Ogledov: 92; Prenosov: 43
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79. Hypotension-induced transverse spinal cord ischemiaPeter Kordiš, Fuad Colakovic, Eva Pipan, 2025, drugi znanstveni članki Povzetek: Background: Spinal cord infarction is rare, with spontaneous, non-traumatic cases being extremely uncommon. Severe atherosclerosis may predispose to spinal ischemia during episodes of systemic hypotension, particularly in mid-thoracic watershed zones. Case report: We present a case of a 56-year-old woman with schizophrenia, a history of heavy smoking, and chronic use of nonsteroidal anti-inflammatory drugs. She presented with ischemic lower limbs and hypotension, following a self-inflicted neck wound. Computed tomography angiography revealed extensive chronic atherosclerotic disease of the distal aorta and iliac arteries with collateral circulation but no acute occlusion. After surgical control of bleeding and stabilization, she was found to have flaccid paraplegia and sensory loss below the TH10 level. Magnetic resonance imaging confirmed acute spinal cord infarction with well-demarcated ischemia, that was treated conservatively. Despite prompt hemodynamic stabilization, her neurological deficits did not resolve. Conclusion: This case highlights spontaneous spinal cord infarction as a rare but serious complication of transient hypotension in patients with severe atherosclerosis. Prompt recognition is essential, though therapeutic options remain limited.
Ključne besede: spinal cord ischemia, hypotension, atherosclerosis, artery of Adamkiewicz, arteria radicularis magna
Objavljeno v DiRROS: 11.12.2025; Ogledov: 101; Prenosov: 35
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80. Adattamento e prevenzione di catastrofi sulla base degli ecosistemi : prospettive per le aree costiere del Nord AdriaticoA. Rosa, Rachele Dandolo, Eleonora Camastra, T. De Lorenzi, Saul Ciriaco, Suzana Škof, Liliana Vižintin, Alessandro Manzardo, Alberto Barausse, 2025, izvirni znanstveni članek Objavljeno v DiRROS: 11.12.2025; Ogledov: 101; Prenosov: 45
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