1091. Evolving strategies in the treatment of childhood rhabdomyosarcoma : Slovenian experienceŽiva Pohar-Marinšek, Jožica Anžič, Berta Jereb, 2001, original scientific article Abstract: Background. Neoadjuvant chemotherapy (Cht) has changed the treatment of rhabdomyosarcoma (RMS) in children. The purpose of our study was to review thechildren treated for RMS between 1974 and 1996. Patients and methods. Fifty-one children, 1-15 years old, were included. Primary sites of tumour were: head and neck 15, orbit 6, genitourinary 12, extremity 9, torso 5 and paratesticular 4. Twelve patients were in stage 1, 10 in stage II, 26 in stage111 and 3 in stage IV. Of 43 histologically confirmed RMS 25 were embryonal, 13 alveolar, 1 botryoid, 1 spindle cell and 3 sarcoma NOS. In 8 patients, only fine needle aspiration biopsy (FNAB) was available. All patients had Cht, 29 neoadjuvant, 20 had surgery first, 40 had irradiation (RT), 2 stage IV patients had bone marrow transplant (ABMT). Multidrug Cht varied: VCR, AMD, and cyclophosphamide (VAC) were used in the 1970s, with Adriablastine (T2), methotrexat (MTX) and/or other drugs (T6, T11) in the 1980s; and in the 1990s, cyclophosphamide was replaced by ifosfamide (VAIA). The treatment was started with Cht in orbital and head and neck tumours and inthe majority of genitourinary tumours, but surgery was first in paratesticular and in the majority of extremity tumours. Results. The 3 patients with stage IV disease died. Of those with localised tumour, 34 (70%) were alive and well 5 years after treatment, 80% stage I, 75% stage II and 61%stage III. One patient died of heart failure, 3 of Cht toxicity and 1 of intereurrent disease. Conclusions. (Abstract truncated at 2000 characters)
Published in DiRROS: 26.01.2024; Views: 200; Downloads: 46
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1092. Can we rely on cancer mortality data? Checking the validity of cervical cancer mortality data for SloveniaMaja Primic-Žakelj, Vera Pompe-Kirn, Fani Škrlec, Jožica Šelb-Šemerl, 2001, original scientific article Abstract: Background. Valid inference on cervical cancer mortality is very difficult since - on the basis of death certificates - it is not always possible to distinguish between cervix, corpus and unspecified uterine cancer deaths. Our aim was to estimate the extent to which cervical cancer as the official cause of death reflects the true mortality from cervical cancer in Slovenia. Material and methods. The data on 2245 deaths from cervix, corpus uteri, and uterus-unspecified cancers for the period 1985-1999 were linked to the Cancer Registry of Slovenia database from the mortality database of Slovenia. Results. Officially, in the period 1985-1999, there were 878 cervical cancer deaths. The comparison of these causes of death with the cancer sites registered in the Cancer Registry revealed that they include only 87.7 % patients with a previous diagnosis of cervical cancer. Of 650 corpus uteri cancer deaths, 17.1% of patients were registered to have cervical cancer, and of 717 unspecified uterine cancer deaths, 31.4% were registered. Taking into account the correctly identified cervical cancer cases among cervical cancer deaths and misclassified cervical cancer deaths as corpus uteri and unspecified uterine, the corrected number of deaths would be 1106. Conclusions. When evaluating the impact of cervical cancer mortality from national mortality rates, the stated underestimation should be taken into account. However, this does not hold for some other cancers.
Published in DiRROS: 26.01.2024; Views: 213; Downloads: 66
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1093. Characterisation of a 3D-printed alkali-activated material based on waste mineral wool at room and elevated temperaturesMajda Pavlin, Barbara Horvat, Romana Cerc Korošec, Rok Capuder, Lidija Korat, Vilma Ducman, 2024, original scientific article Keywords: recycling, alkalijsko aktivirani materiali, 3D print, mineralna volna
Published in DiRROS: 25.01.2024; Views: 377; Downloads: 185
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1094. Cell electropermeabilization to small molecules in vitro : control by pulse parametersAlenka Maček Lebar, Damijan Miklavčič, 2001, original scientific article Abstract: A systematic study concerning the role of the different electric field parameters (pulse number, duration and amplitude) on electropermeabilization of DC3F cells to small molecules (propidium iodide) and on cell viability is presented. Cell permeabilization and viability dependence on the pulse amplitude was determined by twenty different sets of electrical parameters. The number of pulses varied between 1 and 64 and pulse duration between 20 micros and 1 ms. The most important parameter was the pulse amplitude because at triggered the electropermeabilization process and the process of cell death. Either in the case of electropermeabilization as well as in the case ofcell viability experiments, the parameter Uso (the pulse amplitude leading to permeabilization or to the death of 50% of cell population) was not changedif the set of electrical parameters consisted of more than 16 pulses. This was independent of the pulse duration. The efficiency of permeabilizationwas enhanced by using of longer pulses. Such a systematic study of the influence of different electric field parameters on electropermeabilization and cell viability may serve as a base for optimization of the electropermeabilization conditions for different applications.
Published in DiRROS: 25.01.2024; Views: 251; Downloads: 58
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1095. Bifocal primary intracranial germinoma in a child. Case reportAleš Koren, 2001, professional article Abstract: Background. Bifocal primary intracranial germinal tumors are rare. Only 5-10% of all germ cell tumors are found both in the suprasellar and pineal region. Case report. In presented patient we found two primary intracranial germinomasin pituitary and pineal gland that were successfully operated. Radiological properties of germinomas and differential diagnosis are discussed. Conclusions. Although the definite histological diagnosis cannot beachieved by computer tomography and/or magnetic resonance images alone, a detailed analysis of neuroradiological images is useful for predicting the histologieal diagnosis.
Published in DiRROS: 25.01.2024; Views: 234; Downloads: 52
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1096. MRI macromolecular contrast agents as indicators of changed tumor blood flowTeodora Ivanuša, Katarina Beravs, Maja Čemažar, Vladimir Jevtič, Franci Demšar, Gregor Serša, 2001, original scientific article Abstract: Background. A rapid mapping technique derived from dynamic contrast enhanced MRI data was used to identify and characterize reduction of blood flow in fibrosarcoma SA-1 tumors treated either by application of electric pulses or vinblastine. Materials and methods. Tissue permeability surface area product (PS) and fractional blood volume (BV) were calculated on a pixel-by-pixel basis using dynamic MRI intensity data after administration of gadomer - 17 orpolylysine-Gd-DTPA; prototypic macromolecular contrast agents designed for blood pool enhancement. PS and BV values of untreated tumors were compared to those of tumors treated by local application of 8 electric pulses (amplitude/distance ratio, 1300 V/cm; duration, 100 us, frequency, 1 Hz) percutaneously to the tumor or by systemic administration of vinblastine (2.5 mg/kg). Results. Both treatments transiently, but significantly reduced tumor blood flow, application of electric pulses to the tumors being by 40% more effective in reducing tumor blood flow than systemic administration of vinblastine. PS and BV values derived with polylysine-Gd-DTPA-enhanced MRI were lower compared to those with gadomer-17, due to larger molecular size. Interestingly, Gd-DTPA-enhanced MRI did not show any significant changes of PSand BV between untreated and treated tumors. Conclusion. This study demonstrates that dynamic contrast enhanced MRI can be effectively used to qualitatively monitor tumor blood flow, and quantitatively by means of BV and PS.
Published in DiRROS: 25.01.2024; Views: 272; Downloads: 53
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1097. Radical irradiation of the prostate. Combination of percutaneous irradiation and irradiation with LDR Ir-192 implantsBorut Kragelj, Franc Guna, Janez Burger, 2001, original scientific article Abstract: Background. The irradiation of the carcinomas of the prostate with the doses above the tolerable ones of standard radiotherapy improves the local control of the disease. The aim of this study is to determine the acute toxicity and tolerability of the high-dose prostate irradiation combining external beam radiotherapy (EBRT) and interstitial low dose rate (LDR) brachyradiotherapy (BRT) Ir-192 of the prostate. Material and methods. We examined medical records of 8 patients with localized carcinoma of the prostate (T2-T3 No-x Mo)treated from August 1999 until February 2000. The initial PSA was 2.7-37.5 ng/ml (median 13.7) and Gleason score 4-9 (median 7). Radiotherapy consisted of 48.6-50.4 Gy of EBRT to the prostate and seminal vesicles (4 patients) or the whole pelvis (4 patients) and 20.0-28.0 Gy of interstital LDR Ir-192 BRT given as a single fraction, fluoroscopic guided transperineal Implantation of the prostate. The cumulative doses of percutaneous and interstitial irraditations to the prostate were 68.6 - 79.1 Gy. Results. Acute toxic effects of irradiation though observed in all patients were of only mild intensity. According to the RTOG criteria, 20/30 toxicities were assessed as grade 1, 9/30 as grade 2, and 1/30 as grade 3. In none of the patients, toxic effects required any specific modification of the treatment regimen. Conclusions. The very first experiences indicate moderate toxicity and optimaltolerance of the treatment by patients. An improvement of implantation techniques may be expected with regular CT controls of the implants and extra attentive care of the implants in the urethra region.
Published in DiRROS: 25.01.2024; Views: 207; Downloads: 68
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1098. What is current practice in soft tissue sarcoma grading?Rastko Golouh, Matej Bračko, 2001, original scientific article Abstract: Purpose. Most published grading systems of soft tissue sarcomas (STS) are somewhat subjective and it seems that there is no definite consensus among experts which of them is the most effective. The aim of this study was to collect data from practicing pathologists and to get some insight in the practice of STS grading. Subjects. A questionnaire was sent to 135 pathologists chosen randomly. Results. There were 88 responders from 30 countries from 5 continents. Most responders (85%) grade STS, more frequently in Europe than in non-European countries. Three-grade system is preferred by both European and non-European pathologists, who use it in almost 77% and 67%,respectively. They apply the criteria set by FNCLCC in 37.3%, by NCI in 24%, by Broders in 12% and by Markhede in 1.4%. In Europe, FNCLCC system is the most widely used. Beside classical histological criteria, other modern methods are applied by more than one half of the responders. Immunohistochemical evaluation of proliferation markers is the method most widely used, followed by molecular markers and DNA flow cytometry. Conclusion.The results of our study indicate that most pathologists consider histologic grade of STS as a valuable, however not completely satisfactory predictor of a patients survival.
Published in DiRROS: 25.01.2024; Views: 251; Downloads: 63
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1099. Computer systems for determination od pressure distribution in the hip joint articular surface : validation and resultsVlado Stankovski, Dragica Smrke, 2001, original scientific article Abstract: Background. In this work, we describe the computer systems Viprecox and ActiveContours that are used in the process of realistic estimation of some biomechanical parameters of the hip joint, including the maximal value of the stress in the hip joint p max. The computer system Active Contours uses standard anteroposterior radiographs of the whole pelvis and both hips for itscalculations and Viprecox in its kernel uses a relatively simple three-dimensional mathematical model of stress distribution in the hip-joint articular surface which has been extensively elsewhere (e.g. Iglič 1996). Material and methods. Both state-of-the-art computer systems were tested by analysing the calculated values of p max for 81 patients (37 males and 44 females). Conclusions. In this way we prove that the described computer systems can be used for the determination of the contact stress distribution from standard AP radiographs.
Published in DiRROS: 25.01.2024; Views: 217; Downloads: 43
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1100. Upgrading of gamma cameras for developing countriesValentin Fidler, Milan Prepadnik, Yanfen Xie, 2001, original scientific article Abstract: Background. The project of upgrading the analog gamma cameras with PC based systems from International Atomic Energy Agency (IAEA) and the Ministry of Science and Technology of RS is presented from the initial basic demands to the final developments. Several national research groups (from China, India, Cuba and Slovenia) were involved in the IAEA development project for the acquisition card with software and the standard set of clinical protocols. Conclusions. The most functionally stable acquisition system tested on severalinternational workshops and in university clinics was the Slovenian onewith a complete set of nuclear medicine clinical protocols, documenting, networking and archiving solutions for simple MS Network or server oriented network systems (NT server, etc). More than 300 gamma cameras in 52 countries all over the world were digitized and put in routine clinical work.
Published in DiRROS: 25.01.2024; Views: 236; Downloads: 42
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