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Title:Bolezni, ki jih povzročajo humani virusi papiloma, in preprečevanje s cepljenjem
Authors:Uršič-Vrščaj, Marjetka (Author)
Language:Slovenian
Tipology:1.04 - Professional Article
Organisation:Logo OI - Institute of Oncology
Abstract:Okužbe s humanimi virusi papiloma (HPV) so zelo pogoste spolno prenosljive bolezni, ki se značilno pojavijo kmalu po začetku spolne dejavnosti. Breme z njimi povezanih bolezni, rakavih in nerakavih, je veliko za ženske in moške. HPV, ki prinašajo veliko tveganje, visokotvegani ali onkogeni HPV pri ženskah povzročajo raka materničnega vratu, nožnice in zunanjega spolovila, pri moških pa raka penisa ter pomemben delež raka žrela in raka zadnjika pri ženskah in moških. Pred nekaj leti sta bili izdelani cepivi, ki preprečujeta okužbo z 2 genotipoma, ki povzročata raka (HPV 16 in 18). Pri neokuženih osebah v približno 95 % učinkovito preprečujeta bolezni, ki jih povzročata oba genotipa, ne zdravita pa okužbe. Profilaktični cepivi sta prvi, ki so ju naredili, da bi pri človeku preprečevali raka.
Keywords:papiloma virusi, preventivna medicina, cepljenje
Year of publishing:2011
COBISS_ID:1105787 Link is opened in a new window
UDC:616-006.6
ISSN on article:1408-1741
OceCobissID:65324032 Link is opened in a new window
URN:URN:NBN:SI:doc-69OYN8KU
Views:2142
Downloads:587
Files:.pdf PDF - Presentation file, download (156,64 KB)
 
Journal:Onkologija
Onkološki inštitut
 
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License:CC BY 4.0, Creative Commons Attribution 4.0 International
Link:http://creativecommons.org/licenses/by/4.0/
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:31.08.2018

Secondary language

Language:English
Title:Human Papillomavirus-Related Diseases and Prevention with Vaccination
Abstract:Human papillomavirus (HPV) is an extremely prevalent sexually transmited infection that is typically acquired soon after the onset of sexual activity. The burden of HPV-related malignant and nonmalignant disease is high in women and men. High-risk or oncogenic types of HPV cause cervical, vaginal, and vulvar vancer in women. These types have also been shown to cause penile cancer in men and a substantial proportion of oropharingeal and anal cancer in women and men. Low-risk types of HPV cause anogenital warts. Virus-like particle-based vaccines have recently been developed to prevent the infection with two cancer-associated HPV genotypes (HPV 16, HPV 18) and have been ~ 95% effective in preventing HPV-associated disease caused by genotypes in virus-naive subjects. The prophylactic vaccines are not therapeutic for the already present infection. HPV prophylactic vaccines are the first vaccines designed to prevent a human cancer.

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