20.500.12556/DiRROS-8717 Bolezni, ki jih povzročajo humani virusi papiloma, in preprečevanje s cepljenjem Human Papillomavirus-Related Diseases and Prevention with Vaccination Okužbe s humanimi virusi papiloma (HPV) so zelo pogoste spolno prenosljive bolezni, ki se značilno pojavijo kmalu po začetku spolne dejavnosti. Breme z njimi povezanih bolezni, rakavih in nerakavih, je veliko za ženske in moške. HPV, ki prinašajo veliko tveganje, visokotvegani ali onkogeni HPV pri ženskah povzročajo raka materničnega vratu, nožnice in zunanjega spolovila, pri moških pa raka penisa ter pomemben delež raka žrela in raka zadnjika pri ženskah in moških. Pred nekaj leti sta bili izdelani cepivi, ki preprečujeta okužbo z 2 genotipoma, ki povzročata raka (HPV 16 in 18). Pri neokuženih osebah v približno 95 % učinkovito preprečujeta bolezni, ki jih povzročata oba genotipa, ne zdravita pa okužbe. Profilaktični cepivi sta prvi, ki so ju naredili, da bi pri človeku preprečevali raka. Human papillomavirus (HPV) is an extremely prevalent sexually transmited infection that is typically acquired soon after the onset of sexual activity. The burden of HPV-related malignant and nonmalignant disease is high in women and men. High-risk or oncogenic types of HPV cause cervical, vaginal, and vulvar vancer in women. These types have also been shown to cause penile cancer in men and a substantial proportion of oropharingeal and anal cancer in women and men. Low-risk types of HPV cause anogenital warts. Virus-like particle-based vaccines have recently been developed to prevent the infection with two cancer-associated HPV genotypes (HPV 16, HPV 18) and have been ~ 95% effective in preventing HPV-associated disease caused by genotypes in virus-naive subjects. The prophylactic vaccines are not therapeutic for the already present infection. HPV prophylactic vaccines are the first vaccines designed to prevent a human cancer. papiloma virusi preventivna medicina cepljenje true false true Slovenski jezik Angleški jezik by Authors Neznano 2018-08-31 13:28:52 2018-08-31 13:28:52 2022-08-16 10:16:10 0000-00-00 00:00:00 2011 0 0 str. 5-9 št. 1 Letn. 15 jun. 2011 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616-006.6 1408-1741 URN:NBN:SI:doc-69OYN8KU 1105787 65324032 RAZ_Ursic-Vrscaj_Marjetka_i2011.pdf RAZ_Ursic-Vrscaj_Marjetka_i2011.pdf 1 022930806674F81161CFFAC61FA683AE d41e135a6aa7921fccee4a1103fc7650860c22add09fe8441a8c2f25b6cd990d 5994a448-17b5-11ed-b6b8-001a4af901a5 20.500.12556/dirros/b138f698-ebf7-4e17-b65f-d6e9f47a7ee7 https://dirros.openscience.si/Dokument.php?lang=slv&id=10498 Onkološki inštitut Ljubljana Onkologija : strokovni časopis za zdravnike 0 0 0