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Title: Nove možnosti citopatološke diagnostike raka sečnega mehurja s testom UroVysion Authors: ID Strojan Fležar, Margareta (Author) ID Srebotnik-Kirbiš, Irena (Author) Files: PDF - Presentation file, download (501,17 KB) MD5: 405065A75CAC0B105E564BC9D4BDC78E PID: 20.500.12556/dirros/332157d7-d06e-461c-92c1-6a74f542b07e   Language: Slovenian Typology: 1.04 - Professional Article Organization: OI - Institute of Oncology Keywords: sečni mehur, rak (medicina), citološka diagnostika Publication status: Published Publication version: Version of Record Year of publishing: 2009 Number of pages: str. 130-132, 153 Numbering: Letn. 13, št. 2 PID: 20.500.12556/DiRROS-8619  UDC: 616.62-006-07 ISSN on article: 1408-1741 URN: URN:NBN:SI:doc-9XB4AZO1 COBISS.SI-ID: 27082969  Copyright: by Authors Note: BSDOCID151741; Publication date in DiRROS: 31.08.2018 Views: 3020 Downloads: 893 Metadata:    Cite this work Plain text BibTeX EndNote XML EndNote/Refer RIS ABNT ACM Ref AMA APA Chicago 17th Author-Date Harvard IEEE ISO 690 MLA Vancouver : Copy citation

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Record is a part of a journal

Title:	Onkologija
Shortened title:	Onkologija
Publisher:	Onkološki inštitut
ISSN:	1408-1741
COBISS.SI-ID:	65324032

Licences

License:	CC BY 4.0, Creative Commons Attribution 4.0 International
Link:	http://creativecommons.org/licenses/by/4.0/
Description:	This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:	31.08.2018

Secondary language

Language:	English
Title:	New Promises of Cytopathologic Diagnostics of Bladder cancer by Using UroVysion™
Abstract:	Cytopathologic examination of the urine and bladder washing is a standard method for the detection of primary bladder cancer in symptomatic patients or in patients with hematuria. The method is also very useful to follow the patients after treatment in order to detect recurrence of bladder cancer which occurs in a significant percentage of patients. Cytopathologic examination is highly accurate for the diagnosis of high grade urothelial carcinoma and carcinoma in situ. However, the method is recognized as being unreliable for the detection of low grade urothelial neoplasms. Obvious cellular and nuclear morphological signs of malignancy can be reliably recognized in high grade papillary, invasive and in situ urothelial carcinoma. Thus, less pronounced cellular atypia pose everyday diagnostic problems and atypia of low grade papillary neoplasms cannot be always reliably differentiated from atypia of some benign and post-treatment reactive changes. In the last decade a number of new urinary markers have been developed to overcome low sensitivity of urinary cytology. Although most of these tests are highly sensitive, they have lower specificity than cytology. The UroVysion test seems the most promising among the new tests. By the method of multitarget fluorescent in situ hybridisation (FISH), the test can detect several cytogenetic changes characteristic for different grades of bladder cancer. Therefore, the UroVysion test is useful for assessing neoplastic nature of cytologically undetermined atypical cells. The most recent reports claim that the UroVysion test can even detect bladder cancer before morphological changes are diagnosed in urine cytology.

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