Cirkulirajoče tumorske celice in njihov pomen pri raku dojke : pregled izsledkov dosedanjih raziskav

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Title:	Cirkulirajoče tumorske celice in njihov pomen pri raku dojke : pregled izsledkov dosedanjih raziskav
Authors:	ID Marinko, Tanja (Author) ID Lah Turnšek, Tamara (Author) ID Serša, Gregor (Author)
Files:	PDF - Presentation file, download (335,84 KB) MD5: 7B6C7E1F7D10F51D50D5517FAB0E3F16 PID: 20.500.12556/dirros/5bc867a8-a621-4819-bb2a-28959edaf2ff
Language:	Slovenian
Typology:	1.04 - Professional Article
Organization:	OI - Institute of Oncology
Keywords:	tumor, onkologija, dojke, prognoza, zasevki
Publication status:	Published
Publication version:	Version of Record
Year of publishing:	2011
Number of pages:	str. 79-82
Numbering:	Letn. 15, št. 2
PID:	20.500.12556/DiRROS-8593
UDC:	618.19-006.6
ISSN on article:	1408-1741
URN:	URN:NBN:SI:doc-B98AV2ZQ
COBISS.SI-ID:	1194619
Copyright:	by Authors
Publication date in DiRROS:	31.08.2018
Views:	3552
Downloads:	952
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Title:	Onkologija. strokovni časopis za zdravnike
Shortened title:	Onkologija
Publisher:	Onkološki inštitut
ISSN:	1408-1741
COBISS.SI-ID:	65324032

License:	CC BY 4.0, Creative Commons Attribution 4.0 International

Link:	http://creativecommons.org/licenses/by/4.0/
Description:	This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:	31.08.2018

Language:	English
Title:	Circlulation of tumor cells and their effect on breast cancer – reviewing the results of previous studies
Abstract:	Circulating tumor cells (CTCs) are epithelial tumor cells detected in the peripheral blood of patients with solid malignant tumors. They originate from the primary tumor or metastatic sites. New techniques have been developed to isolate and characterise these cells, including the FDA-approved CellSearch, which are using mainly cytometric/antibody-based and molecular approaches. Recent advances in theories regarding metastasis support the role of early release of tumor cells in the neoplastic process. It has been found that phenotypic variation exists between the primary tumor and CTCs. Of particular interest is the difference found between primary tumor and CTC HER-2 status in both metastatic and early breast cancer. CTC enumeration has been incorporated into different fields of oncology as a prognostic marker, a tool to monitor therapy response, and a method to understand basic tumor characteristics. But currently, there is still no role for CTCs in clinical practice.