| Title: | Patient-reported health-related quality of life impact and symptom severity in patients with Lyme borreliosis in the Burden of Lyme Disease (BOLD) study |
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| Authors: | ID Yu, Holly (Author)
ID Mercadante, Amanda R. (Author)
ID Halsby, Kate (Author)
ID Loew-Baselli, Alexandra (Author)
ID Tan, Ye (Author)
ID Edwards, Juanita (Author)
ID Strle, Franc (Author), et al. |
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| Files: |  PDF - Presentation file, download (951,27 KB)
MD5: 490CCB5409F8E5D307F5D5438417F77B
 URL - Source URL, visit https://www.mdpi.com/2076-0817/15/7/701
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  UKC LJ - Ljubljana University Medical Centre
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| Abstract: | Lyme borreliosis (LB) can manifest as a localized infection or, if left untreated, disseminated disease. This analysis used Patient-Reported Outcome tools to assess general health, fatigue, pain, and cognitive function in patients with localized or disseminated LB, compared with age- and site-matched controls without LB. All participants were enrolled in the Burden of Lyme Disease (BOLD) study; LB cases were assessed at 3 time points: the enrollment visit, and two follow-up visits conducted within 10 months of enrollment. Controls were evaluated at 2 time points: the enrollment contact and a follow-up contact 16–18 months post-enrollment. Symptom severity and general health quality between groups were compared using two-tailed Student’s t-tests and multivariate regression analyses. Disseminated LB cases reported greater fatigue and pain than localized LB (disseminated LB fatigue scores: 4.1, 3.7, and 3.5 at Visits 1, 2, and 3, respectively vs. localized LB: 2.9, 3.0, and 2.9; disseminated LB pain scores: 2.5, 1.6, and 1.3 vs. localized LB: 0.9, 0.6, and 0.8) and controls (fatigue score: 3.2; pain score: 1.0). Disseminated LB was also associated with reduced health-related quality of life. The results of this study indicate that health-related quality of life may vary by disease stage and that patients with disseminated disease showed persistent impairment during the acute phase and at 10-month follow-up. |
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| Keywords: | Lyme borreliosis, Lyme disease, disseminated LB, localized LB, patient-reported outcomes, quality of life |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Year of publishing: | 2026 |
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| Number of pages: | str. 1-16 |
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| Numbering: | Vol. 15, issue 7, [article no.] 701 |
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| PID: | 20.500.12556/DiRROS-31347  |
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| UDC: | 616.9 |
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| ISSN on article: | 2076-0817 |
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| DOI: | 10.3390/pathogens15070701 |
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| COBISS.SI-ID: | 286281475 |
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| Note: | Nasl. z nasl. zaslona;
Opis vira z dne 29. 7. 2026;
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| Publication date in DiRROS: | 29.07.2026 |
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| Views: | 35 |
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| Downloads: | 28 |
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