20.500.12556/DiRROS-31347 Patient-reported health-related quality of life impact and symptom severity in patients with Lyme borreliosis in the Burden of Lyme Disease (BOLD) study Lyme borreliosis (LB) can manifest as a localized infection or, if left untreated, disseminated disease. This analysis used Patient-Reported Outcome tools to assess general health, fatigue, pain, and cognitive function in patients with localized or disseminated LB, compared with age- and site-matched controls without LB. All participants were enrolled in the Burden of Lyme Disease (BOLD) study; LB cases were assessed at 3 time points: the enrollment visit, and two follow-up visits conducted within 10 months of enrollment. Controls were evaluated at 2 time points: the enrollment contact and a follow-up contact 16–18 months post-enrollment. Symptom severity and general health quality between groups were compared using two-tailed Student’s t-tests and multivariate regression analyses. Disseminated LB cases reported greater fatigue and pain than localized LB (disseminated LB fatigue scores: 4.1, 3.7, and 3.5 at Visits 1, 2, and 3, respectively vs. localized LB: 2.9, 3.0, and 2.9; disseminated LB pain scores: 2.5, 1.6, and 1.3 vs. localized LB: 0.9, 0.6, and 0.8) and controls (fatigue score: 3.2; pain score: 1.0). Disseminated LB was also associated with reduced health-related quality of life. The results of this study indicate that health-related quality of life may vary by disease stage and that patients with disseminated disease showed persistent impairment during the acute phase and at 10-month follow-up. Lyme borreliosis Lyme disease disseminated LB localized LB patient-reported outcomes quality of life lymska borelioza lymska bolezen diseminirana lymska borelioza lokalizirana lymska borelioza izid bolezni kvaliteta življenja true false true Angleški jezik Slovenski jezik Neznano 2026-07-29 11:34:57 2026-07-29 11:34:58 2026-07-30 03:49:46 0000-00-00 00:00:00 2026 0 0 Nasl. z nasl. zaslona; Opis vira z dne 29. 7. 2026; str. 1-16 issue 7, [article no.] 701 Vol. 15 2026 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.9 2076-0817 10.3390/pathogens15070701 286281475 RAZ_Yu_Holly_2026.pdf RAZ_Yu_Holly_2026.pdf 1 490CCB5409F8E5D307F5D5438417F77B d43358692d5e4301ef579d274734c18861962831d0021901fe8d3a7b5e979eb4 fcd2b79b-8b30-11f1-923b-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=48492 https://www.mdpi.com/2076-0817/15/7/701 1 c47dce72-8b30-11f1-923b-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=48491 Univerzitetni klinični center Ljubljana 0 0 0