| Title: | Bronchopulmonary dysplasia and innate immunity : a narrative review of the roles of IL-1β and IL-8 (CXCL8) |
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| Authors: | ID Bačaj Ivanić, Dubravka (Author)
ID Grosek, Štefan (Author)
ID Kopitar, Andreja Nataša (Author) |
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| Files: |  PDF - Presentation file, download (1,92 MB)
MD5: 87780DBAC56508490CFA943D9D3B0053
 URL - Source URL, visit https://www.mdpi.com/2227-9067/13/7/888
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| Language: | English |
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| Typology: | 1.02 - Review Article |
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| Organization: |  UKC LJ - Ljubljana University Medical Centre
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| Abstract: | Background: Bronchopulmonary dysplasia (BPD) is a leading chronic lung complication in extremely premature newborns. The etiological factors contributing to of BPD include both prenatal and postnatal risk factors, as well as activation of innate immunity. Innate immunity and its bioactive mediators play a central role in orchestrating the inflammatory response. Among these, interleukin-1β (IL-1 β) and IL-8 (CXCL8) are particularly prominent. Methods: A structured literature search was conducted across major biomedical databases (PubMed, Scopus, Web of Science, and Ovid MEDLINE) to identify relevant studies published between 1993 and November 2025. Article selection was guided by predefined inclusion criteria focusing on studies that examined IL-1β and IL-8 (CXCL8) in relation to bronchopulmonary dysplasia. Evidence from both human and animal studies was narratively synthesized. Results: This review provides a detailed description of the role of the innate immune system in BPD, including mechanisms of inflammatory initiation, evidence from human and animal studies on IL-1β and IL-8 (CXCL8), and the interaction between these two cytokines in the development of chronic lung disease. Conclusions: Both human and animal studies generally suggest that elevated levels of IL-1β and IL-8 (CXCL8) are closely associated with the development of bronchopulmonary dysplasia in premature infants. |
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| Keywords: | premature infant, chronic lung disease, inflammation, cytokines, chemokines |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Year of publishing: | 2026 |
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| Number of pages: | str. 1-23 |
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| Numbering: | Vol. 13, iss. 7, [article no.] 888 |
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| PID: | 20.500.12556/DiRROS-31228  |
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| UDC: | 616-053.2 |
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| ISSN on article: | 2227-9067 |
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| DOI: | 10.3390/children13070888 |
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| COBISS.SI-ID: | 283972867 |
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| Note: | Nasl. z nasl. zaslona;
Opis vira z dne 7.. 7. 2026;
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| Publication date in DiRROS: | 22.07.2026 |
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| Views: | 218 |
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| Downloads: | 111 |
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