20.500.12556/DiRROS-31228 Bronchopulmonary dysplasia and innate immunity a narrative review of the roles of IL-1β and IL-8 (CXCL8) Background: Bronchopulmonary dysplasia (BPD) is a leading chronic lung complication in extremely premature newborns. The etiological factors contributing to of BPD include both prenatal and postnatal risk factors, as well as activation of innate immunity. Innate immunity and its bioactive mediators play a central role in orchestrating the inflammatory response. Among these, interleukin-1β (IL-1 β) and IL-8 (CXCL8) are particularly prominent. Methods: A structured literature search was conducted across major biomedical databases (PubMed, Scopus, Web of Science, and Ovid MEDLINE) to identify relevant studies published between 1993 and November 2025. Article selection was guided by predefined inclusion criteria focusing on studies that examined IL-1β and IL-8 (CXCL8) in relation to bronchopulmonary dysplasia. Evidence from both human and animal studies was narratively synthesized. Results: This review provides a detailed description of the role of the innate immune system in BPD, including mechanisms of inflammatory initiation, evidence from human and animal studies on IL-1β and IL-8 (CXCL8), and the interaction between these two cytokines in the development of chronic lung disease. Conclusions: Both human and animal studies generally suggest that elevated levels of IL-1β and IL-8 (CXCL8) are closely associated with the development of bronchopulmonary dysplasia in premature infants. premature infant chronic lung disease inflammation cytokines chemokines nedonošenček kronična pljučna bolezen vnetje citokini kemokini true false true Angleški jezik Slovenski jezik Neznano 2026-07-22 13:54:58 2026-07-22 13:54:58 2026-07-23 03:51:09 0000-00-00 00:00:00 2026 0 0 Nasl. z nasl. zaslona; Opis vira z dne 7.. 7. 2026; str. 1-23 iss. 7, [article no.] 888 Vol. 13 May 2026 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616-053.2 2227-9067 10.3390/children13070888 283972867 RAZ_Bacaj_Ivanic_Dubravka_2026.pdf RAZ_Bacaj_Ivanic_Dubravka_2026.pdf 1 87780DBAC56508490CFA943D9D3B0053 dc9011e3d6d9d90665468a78e1f73571b293cb595abb90b04c0daa1d1f307aa0 3b52794d-85c4-11f1-a226-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=48202 https://www.mdpi.com/2227-9067/13/7/888 1 2af07d30-85c4-11f1-a226-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=48201 Univerzitetni klinični center Ljubljana 0 0 0