| Title: | Management of Tacrolimus-induced thrombotic microangiopathy in a heart transplant recipient : utilizing novel immunosuppression strategies |
|---|
| Authors: | ID Girandon Sušanj, Petra (Author)
ID Okrajšek, Renata (Author)
ID Frljak, Sabina (Author)
ID Zemljič, Gregor (Author)
ID Cerar, Andraž (Author)
ID Šebeštjen, Miran (Author)
ID Ugovšek, Sabina (Author)
ID Bajec, Tine (Author)
ID Poglajen, Gregor (Author) |
|---|
| Files: |  PDF - Presentation file, download (1,51 MB)
MD5: A34D5721CABD9F99065A55546F11FBE4
 URL - Source URL, visit https://www.jhltopen.org/article/S2950-1334(26)00117-5/fulltext
|
|---|
| Language: | English |
|---|
| Typology: | 1.03 - Other scientific articles |
|---|
| Organization: |  UKC LJ - Ljubljana University Medical Centre
|
|---|
| Abstract: | Thrombotic microangiopathy (TMA) represents a heterogeneous group of disorders characterized by endothelial injury, complement activation, and platelet aggregation, and may occur in association with systemic diseases, infections, or drug exposure. In solid organ transplant recipients, TMA is most commonly linked to immunosuppressive therapy, particularly calcineurin inhibitors and mammalian target of rapamycin inhibitors, with increased risk during combined use. Drug-induced TMA is rare but potentially life-threatening, and management relies primarily on prompt withdrawal of the offending agent and modification of immunosuppression. We report the successful use of belatacept-based immunosuppression in a heart transplant recipient with tacrolimus-associated TMA. Belatacept, a selective T-cell costimulation blocker, represents a promising alternative immunosuppressive strategy in this setting, particularly in patients with drug-related vascular toxicity. |
|---|
| Keywords: | thrombotic microangiopathy, calcineurin inhibitors, mechanistic target of rapamycin, belatacept |
|---|
| Publication status: | Published |
|---|
| Publication version: | Version of Record |
|---|
| Year of publishing: | 2026 |
|---|
| Number of pages: | 4 str. |
|---|
| Numbering: | Vol. 13, article no. ǂ100596 |
|---|
| PID: | 20.500.12556/DiRROS-30693  |
|---|
| UDC: | 616.1 |
|---|
| ISSN on article: | 2950-1334 |
|---|
| DOI: | 10.1016/j.jhlto.2026.100596 |
|---|
| COBISS.SI-ID: | 281921539 |
|---|
| Note: | Nasl. z nasl. zaslona;
Opis vira z dne 17. 6. 2026;
|
|---|
| Publication date in DiRROS: | 01.07.2026 |
|---|
| Views: | 76 |
|---|
| Downloads: | 59 |
|---|
| Metadata: |    |
|---|
|
:
|
Copy citation |
|---|
| | | | Share: |  |
|---|
Hover the mouse pointer over a document title to show the abstract or click
on the title to get all document metadata. |
