20.500.12556/DiRROS-30693 Management of Tacrolimus-induced thrombotic microangiopathy in a heart transplant recipient utilizing novel immunosuppression strategies Thrombotic microangiopathy (TMA) represents a heterogeneous group of disorders characterized by endothelial injury, complement activation, and platelet aggregation, and may occur in association with systemic diseases, infections, or drug exposure. In solid organ transplant recipients, TMA is most commonly linked to immunosuppressive therapy, particularly calcineurin inhibitors and mammalian target of rapamycin inhibitors, with increased risk during combined use. Drug-induced TMA is rare but potentially life-threatening, and management relies primarily on prompt withdrawal of the offending agent and modification of immunosuppression. We report the successful use of belatacept-based immunosuppression in a heart transplant recipient with tacrolimus-associated TMA. Belatacept, a selective T-cell costimulation blocker, represents a promising alternative immunosuppressive strategy in this setting, particularly in patients with drug-related vascular toxicity. thrombotic microangiopathy calcineurin inhibitors mechanistic target of rapamycin belatacept true false true Angleški jezik Ni določen Neznano 2026-07-01 10:31:00 2026-07-01 10:31:00 2026-07-03 03:46:47 0000-00-00 00:00:00 2026 0 0 Nasl. z nasl. zaslona; Opis vira z dne 17. 6. 2026; 4 str. article no. ǂ100596 Vol. 13 2026 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.1 2950-1334 10.1016/j.jhlto.2026.100596 281921539 RAZ_Girandon_Susanj_Petra_2026.pdf RAZ_Girandon_Susanj_Petra_2026.pdf 1 A34D5721CABD9F99065A55546F11FBE4 20d00c78390b675a3d4783509a218282ab1205ff18919388facd71c5d9b92fa2 a8442215-75fd-11f1-834d-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=47041 https://www.jhltopen.org/article/S2950-1334(26)00117-5/fulltext 1 31f76853-7527-11f1-b0d9-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=46769 Univerzitetni klinični center Ljubljana 0 0 0