| Title: | Haplotype of the lipoprotein(a) gene variants rs10455872 and rs3798220 is associated with parameters of coagulation, fibrinolysis, and inflammation in patients after myocardial infarction and highly elevated lipoprotein(a) values |
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| Authors: | ID Ugovšek, Sabina (Author)
ID Rehberger Likozar, Andreja (Author)
ID Levstek, Tina (Author)
ID Trebušak Podkrajšek, Katarina (Author)
ID Zupan, Janja (Author)
ID Šebeštjen, Miran (Author) |
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| Files: |  PDF - Presentation file, download (2,32 MB)
MD5: 0E607B5C7ADDB64105EE27461AE83D04
 URL - Source URL, visit https://www.mdpi.com/1422-0067/25/2/736
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  UKC LJ - Ljubljana University Medical Centre
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| Abstract: | Lipoprotein(a) (Lp(a)) is an independent risk factor for future coronary events. Variants rs10455872 and rs3798220 in the gene encoding Lp(a) are associated with an increased Lp(a) concentration and risk of coronary artery disease. We aimed to determine whether in high-risk coronary artery disease patients these two genetic variants and the kringle IV type 2 (KIV-2) repeats are associated with impairment of inflammatory and hemostatic parameters. Patients after myocardial infarction with elevated Lp(a) levels were included. Blood samples underwent biochemical and genetic analyses. In carriers of the AC haplotype, the concentrations of tumor necrosis factor (TNF)-α (4.46 vs. 3.91 ng/L, p = 0.046) and plasminogen activator inhibitor-1 (PAI-1) (p = 0.026) were significantly higher compared to non-carriers. The number of KIV-2 repeats was significantly associated with the concentration of high-sensitivity C-reactive protein (ρ = 0.251, p = 0.038) and overall fibrinolytic potential (r = −0.253, p = 0.038). In our patients, a direct association between the AC haplotype and both TNF-α and PAI-1 levels was observed. Our study shows that the number of KIV-2 repeats not only affects proatherosclerotic and proinflammatory effects of Lp(a) but is also associated with its antifibrinolytic properties. |
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| Keywords: | inflammation, hemostasis, lipoprotein(a), rs10444872, rs3798220, KIV-2 repeats |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Year of publishing: | 2024 |
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| Number of pages: | str. 1-14 |
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| Numbering: | Vol. 25, iss. 2 [article no.] 736 |
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| PID: | 20.500.12556/DiRROS-29962  |
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| UDC: | 616.1 |
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| ISSN on article: | 1422-0067 |
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| DOI: | 10.3390/ijms25020736 |
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| COBISS.SI-ID: | 180713731 |
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| Note: | Nasl. z nasl. zaslona;
Opis vira z dne 12. 11. 2024;
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| Publication date in DiRROS: | 10.06.2026 |
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| Views: | 87 |
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| Downloads: | 71 |
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