20.500.12556/DiRROS-29962 Haplotype of the lipoprotein(a) gene variants rs10455872 and rs3798220 is associated with parameters of coagulation, fibrinolysis, and inflammation in patients after myocardial infarction and highly elevated lipoprotein(a) values Lipoprotein(a) (Lp(a)) is an independent risk factor for future coronary events. Variants rs10455872 and rs3798220 in the gene encoding Lp(a) are associated with an increased Lp(a) concentration and risk of coronary artery disease. We aimed to determine whether in high-risk coronary artery disease patients these two genetic variants and the kringle IV type 2 (KIV-2) repeats are associated with impairment of inflammatory and hemostatic parameters. Patients after myocardial infarction with elevated Lp(a) levels were included. Blood samples underwent biochemical and genetic analyses. In carriers of the AC haplotype, the concentrations of tumor necrosis factor (TNF)-α (4.46 vs. 3.91 ng/L, p = 0.046) and plasminogen activator inhibitor-1 (PAI-1) (p = 0.026) were significantly higher compared to non-carriers. The number of KIV-2 repeats was significantly associated with the concentration of high-sensitivity C-reactive protein (ρ = 0.251, p = 0.038) and overall fibrinolytic potential (r = −0.253, p = 0.038). In our patients, a direct association between the AC haplotype and both TNF-α and PAI-1 levels was observed. Our study shows that the number of KIV-2 repeats not only affects proatherosclerotic and proinflammatory effects of Lp(a) but is also associated with its antifibrinolytic properties. inflammation hemostasis lipoprotein(a) rs10444872 rs3798220 KIV-2 repeats vnetje hemostaza lipoprotein(a) ponovitve KIV-2 true false true Angleški jezik Slovenski jezik Neznano 2026-06-10 12:41:12 2026-06-10 12:41:12 2026-06-11 03:47:35 0000-00-00 00:00:00 2024 0 0 Nasl. z nasl. zaslona; Opis vira z dne 12. 11. 2024; str. 1-14 iss. 2 [article no.] 736 Vol. 25 2024 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.1 1422-0067 10.3390/ijms25020736 180713731 RAZ_Ugovsek_Sabina_2024.pdf RAZ_Ugovsek_Sabina_2024.pdf 1 0E607B5C7ADDB64105EE27461AE83D04 12f836695b09d517c27adaa20c74132c8c576683c2848635d64e69f5f6e13a2d 0781db02-64b9-11f1-9215-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=45129 https://www.mdpi.com/1422-0067/25/2/736 1 e75be9f1-64b8-11f1-9215-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=45128 Univerzitetni klinični center Ljubljana 0 0 0