| Title: | Detection of serum and tissue levels of interleukin 39 in psoriasis : a case control study |
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| Authors: | ID Hassan, Mohammed (Author)
ID Abd El-Raheem, Talal A. (Author)
ID Shake, Olfat G. (Author)
ID Kamal, Hagar Ali (Author)
ID Yaseen, Sara M. (Author)
ID Soliman, Amira E. (Author) |
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| Files: |  URL - Source URL, visit https://acta-apa.mf.uni-lj.si/journals/acta-dermatovenerol-apa/papers/10.15570/actaapa.2025.13/actaapa.2025.13.pdf
 PDF - Presentation file, download (710,20 KB)
MD5: 0000C1AE19F1F4ECB81BDFD644D17CD5
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  ZSD - Association of Slovenian Dermatovenereologists
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| Abstract: | Introduction: Psoriasis is a chronic immune-mediated disorder with a genetic component that primarily affects the skin and has potential systemic involvement. Advances in understanding the interaction between the innate and adaptive immune systems have facilitated improved disease management. Methods: This study included 25 patients with psoriasis and 20 healthy controls of both sexes. All participants underwent detailed medical history-taking and dermatological examination, including assessment of the body surface area and the Psoriasis Area and Severity Index (PASI). Blood samples (3 ml) were collected from all subjects, and 4 mm lesional skin punch biopsies were obtained from psoriatic patients and healthy controls. Results: Serum and tissue levels of interleukin 39 (IL-39) were significantly elevated in psoriatic patients compared to healthy individuals. Patients with a positive family history of psoriasis showed higher serum IL-39 levels than those without such a history. In addition, psoriatic individuals with diabetes mellitus or hypertension had higher serum IL-39 levels than those without these comorbidities. A statistically significant correlation was found between disease severity and serum IL-39 concentration. Conclusions: Elevated serum and tissue IL-39 levels in psoriatic patients suggest a potential role for IL-39 in the pathogenesis of psoriasis, highlighting its possible utility as a biomarker or therapeutic target. |
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| Keywords: | psoriasis, cytokines, autoimmune disease, IL-39, ELISA |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Publication date: | 01.06.2025 |
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| Year of publishing: | 2025 |
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| Number of pages: | str. 45-49 |
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| Numbering: | Vol. 34, issue 2 |
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| PID: | 20.500.12556/DiRROS-29905  |
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| UDC: | 616.5:579 |
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| ISSN on article: | 1318-4458 |
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| DOI: | 10.15570/actaapa.2025.13 |
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| COBISS.SI-ID: | 260272387 |
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| Publication date in DiRROS: | 15.06.2026 |
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| Views: | 43 |
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| Downloads: | 22 |
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