| Title: | Detection of serum and tissue levels of interleukin 39 in psoriasis : a case control study |
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| Authors: | ID Hassan, Mohammed (Author)
ID Abd El-Raheem, Talal A. (Author)
ID Shake, Olfat G. (Author)
ID Kamal, Hagar Ali (Author)
ID Yaseen, Sara M. (Author)
ID Soliman, Amira E. (Author) |
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| Files: |  URL - Source URL, visit https://acta-apa.mf.uni-lj.si/journals/acta-dermatovenerol-apa/papers/10.15570/actaapa.2025.13/actaapa.2025.13.pdf
 PDF - Presentation file, download (710,20 KB)
MD5: 0000C1AE19F1F4ECB81BDFD644D17CD5
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  ZSD - Association of Slovenian Dermatovenereologists
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| Abstract: | Introduction: Psoriasis is a chronic immune-mediated disorder with a genetic component that primarily affects the skin and has potential systemic involvement. Advances in understanding the interaction between the innate and adaptive immune systems have facilitated improved disease management. Methods: This study included 25 patients with psoriasis and 20 healthy controls of both sexes. All participants underwent detailed medical history-taking and dermatological examination, including assessment of the body surface area and the Psoriasis Area and Severity Index (PASI). Blood samples (3 ml) were collected from all subjects, and 4 mm lesional skin punch biopsies were obtained from psoriatic patients and healthy controls. Results: Serum and tissue levels of interleukin 39 (IL-39) were significantly elevated in psoriatic patients compared to healthy individuals. Patients with a positive family history of psoriasis showed higher serum IL-39 levels than those without such a history. In addition, psoriatic individuals with diabetes mellitus or hypertension had higher serum IL-39 levels than those without these comorbidities. A statistically significant correlation was found between disease severity and serum IL-39 concentration. Conclusions: Elevated serum and tissue IL-39 levels in psoriatic patients suggest a potential role for IL-39 in the pathogenesis of psoriasis, highlighting its possible utility as a biomarker or therapeutic target. |
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| Keywords: | psoriasis, cytokines, autoimmune disease, IL-39, ELISA |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Submitted for review: | 05.02.2025 |
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| Article acceptance date: | 22.05.2025 |
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| Publication date: | 01.06.2025 |
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| Place of publishing: | Ljubljana |
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| Publisher: | Združenje slovenskih dermatovenerologov |
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| Year of publishing: | 2025 |
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| Number of pages: | str. 45-49 |
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| Numbering: | Vol. 34, issue 2 |
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| PID: | 20.500.12556/DiRROS-29905  |
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| UDC: | 616.5:579 |
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| ISSN on article: | 1318-4458 |
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| DOI: | 10.15570/actaapa.2025.13 |
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| COBISS.SI-ID: | 260272387 |
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| Copyright: | Na spletni strani revije navedeno: Acta Dermatovenerologica Alpina, Pannonica et Adriatica (ISSN 1318-4458) is an open access medical journal published quarterly by the Association of Slovenian Dermatovenerologists (https://acta-apa.mf.uni-lj.si/index.php); Authors publishing in our journal retain copyright of their work under the Creative Commons Attribution License (CC BY 4.0). This license allows unrestricted use, distribution, and reproduction of the work in any medium, provided the original author(s) and copyright holder(s) are appropriately credited, and the original publication in the journal is properly cited, following established academic practices (https://acta-apa.mf.uni-lj.si/submissions.php). |
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| Publication date in DiRROS: | 15.06.2026 |
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| Views: | 289 |
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| Downloads: | 185 |
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