20.500.12556/DiRROS-29905 Detection of serum and tissue levels of interleukin 39 in psoriasis a case control study Introduction: Psoriasis is a chronic immune-mediated disorder with a genetic component that primarily affects the skin and has potential systemic involvement. Advances in understanding the interaction between the innate and adaptive immune systems have facilitated improved disease management. Methods: This study included 25 patients with psoriasis and 20 healthy controls of both sexes. All participants underwent detailed medical history-taking and dermatological examination, including assessment of the body surface area and the Psoriasis Area and Severity Index (PASI). Blood samples (3 ml) were collected from all subjects, and 4 mm lesional skin punch biopsies were obtained from psoriatic patients and healthy controls. Results: Serum and tissue levels of interleukin 39 (IL-39) were significantly elevated in psoriatic patients compared to healthy individuals. Patients with a positive family history of psoriasis showed higher serum IL-39 levels than those without such a history. In addition, psoriatic individuals with diabetes mellitus or hypertension had higher serum IL-39 levels than those without these comorbidities. A statistically significant correlation was found between disease severity and serum IL-39 concentration. Conclusions: Elevated serum and tissue IL-39 levels in psoriatic patients suggest a potential role for IL-39 in the pathogenesis of psoriasis, highlighting its possible utility as a biomarker or therapeutic target. psoriasis cytokines autoimmune disease IL-39 ELISA luskavica citokini avtoiminska bolezen true false true Angleški jezik Slovenski jezik Neznano 2026-06-09 08:38:06 2026-06-15 20:17:04 2026-06-16 03:54:37 0000-00-00 00:00:00 2025 0 0 str. 45-49 issue 2 Vol. 34 Jun. 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 2025-06-01 616.5:579 1318-4458 10.15570/actaapa.2025.13 260272387 https://acta-apa.mf.uni-lj.si/journals/acta-dermatovenerol-apa/papers/10.15570/actaapa.2025.13/actaapa.2025.13.pdf 1 c66f317d-63cd-11f1-9215-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=45004 RAZ_Hassan_Mohammed_2025.pdf RAZ_Hassan_Mohammed_2025.pdf 1 0000C1AE19F1F4ECB81BDFD644D17CD5 25a5051cfcdbbdb25006451846e520d30fde32b7078288ea9c387579212e781f 7198fd2d-68e6-11f1-aebd-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=45509 Združenje slovenskih dermatovenerologov Acta dermatovenerologica Alpina, Panonica et Adriatica 0 0 0