| Title: | Intraoperative electrochemotherapy of the posterior resection surface after pancreaticoduodenectomy : preliminary results of a hybrid approach treatment of pancreatic cancer |
|---|
| Authors: | ID Čebron, Žan (Author)
ID Djokić, Mihajlo (Author)
ID Petrič, Miha (Author)
ID Čemažar, Maja (Author)
ID Omerzel, Maša (Author)
ID Serša, Gregor (Author)
ID Trotovšek, Blaž (Author) |
|---|
| Files: |  PDF - Presentation file, download (4,65 MB)
MD5: D20A0F70F612F8D23B0104CF901942D3
 URL - Source URL, visit https://www.sciencedirect.com/science/article/pii/S156753942300213X
|
|---|
| Language: | English |
|---|
| Typology: | 1.01 - Original Scientific Article |
|---|
| Organization: |  UKC LJ - Ljubljana University Medical Centre
|
|---|
| Abstract: | Despite extensive research in recent decades, pancreatic cancer continues to be among the most lethal forms of cancer, with no substantial increase in survival rates. Local recurrences account for approximately 30 per cent of all disease recurrences. With the intent to improve survival, we designed a novel, hybrid treatment strategy consisting of surgical resection and additional intraoperative electrochemotherapy of the posterior resection surface. We present the study protocols and preliminary findings of a prospective pilot study investigating this treatment approach. Methods Consenting patients with resectable pancreatic head ductal adenocarcinoma who met the inclusion criteria were enrolled in the study. After surgical resection, electrochemotherapy with bleomycin was performed using plate electrodes to cover the area between anatomical landmarks. Results Electrochemotherapy of the posterior resection surface was feasible in all 7 patients. We observed pancreatic fistula grade B in only one patient; all other noted complications were Clavien-Dindo grade 2 or less. The hospital mortality was 0%. Conclusions Our preliminary results suggest that a hybrid approach combining surgery with intraoperative electrochemotherapy is safe and feasible. |
|---|
| Keywords: | pancreatic cancer, intraoperative electrochemotherapy, electroporation |
|---|
| Publication status: | Published |
|---|
| Publication version: | Version of Record |
|---|
| Year of publishing: | 2024 |
|---|
| Number of pages: | str. 108576-1-108576-7 |
|---|
| Numbering: | Vol. 155 |
|---|
| PID: | 20.500.12556/DiRROS-29732  |
|---|
| UDC: | 602.6/.7 |
|---|
| ISSN on article: | 1567-5394 |
|---|
| DOI: | 10.1016/j.bioelechem.2023.108576 |
|---|
| COBISS.SI-ID: | 165588227 |
|---|
| Publication date in DiRROS: | 04.06.2026 |
|---|
| Views: | 90 |
|---|
| Downloads: | 68 |
|---|
| Metadata: |    |
|---|
|
:
|
Copy citation |
|---|
| | | | Share: |  |
|---|
Hover the mouse pointer over a document title to show the abstract or click
on the title to get all document metadata. |
