20.500.12556/DiRROS-29732 Intraoperative electrochemotherapy of the posterior resection surface after pancreaticoduodenectomy preliminary results of a hybrid approach treatment of pancreatic cancer Despite extensive research in recent decades, pancreatic cancer continues to be among the most lethal forms of cancer, with no substantial increase in survival rates. Local recurrences account for approximately 30 per cent of all disease recurrences. With the intent to improve survival, we designed a novel, hybrid treatment strategy consisting of surgical resection and additional intraoperative electrochemotherapy of the posterior resection surface. We present the study protocols and preliminary findings of a prospective pilot study investigating this treatment approach. Methods Consenting patients with resectable pancreatic head ductal adenocarcinoma who met the inclusion criteria were enrolled in the study. After surgical resection, electrochemotherapy with bleomycin was performed using plate electrodes to cover the area between anatomical landmarks. Results Electrochemotherapy of the posterior resection surface was feasible in all 7 patients. We observed pancreatic fistula grade B in only one patient; all other noted complications were Clavien-Dindo grade 2 or less. The hospital mortality was 0%. Conclusions Our preliminary results suggest that a hybrid approach combining surgery with intraoperative electrochemotherapy is safe and feasible. pancreatic cancer intraoperative electrochemotherapy electroporation rak trebušne slinavke intraoperativna elektrokemoterapija elektroporacija true false true Angleški jezik Slovenski jezik Neznano 2026-06-04 09:53:09 2026-06-04 09:53:09 2026-06-05 04:05:55 0000-00-00 00:00:00 2024 0 0 str. 108576-1-108576-7 Vol. 155 2024 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 602.6/.7 1567-5394 10.1016/j.bioelechem.2023.108576 165588227 RAZ_Cebron_Zan_2024.pdf RAZ_Cebron_Zan_2024.pdf 1 D20A0F70F612F8D23B0104CF901942D3 9c45e0bea64bfeea96f04b7c520de2c913b4315a12994f4be827516b0777f765 8f5b1cb7-5fea-11f1-9215-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=44679 https://www.sciencedirect.com/science/article/pii/S156753942300213X 1 6efd94ae-5fea-11f1-9215-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=44678 Univerzitetni klinični center Ljubljana 0 0 0