| Title: | Quality of life in Slovenian patients with skull base tumours : cross-cultural adaptation and validation of a Slovenian skull base inventory |
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| Authors: | ID Vozel, Domen (Author)
ID Urbančič, Jure (Author)
ID Battelino, Saba (Author)
ID Božanić Urbančič, Nina (Author)
ID Steiner, Nejc (Author)
ID Felbabić, Tomislav (Author)
ID Bošnjak, Roman (Author) |
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| Files: |  PDF - Presentation file, download (862,32 KB)
MD5: CDA02E6B276E94DE177278037FC79015
 URL - Source URL, visit https://reference-global.com/article/10.2478/raon-2026-0007
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  UKC LJ - Ljubljana University Medical Centre
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| Abstract: | Background: Skull base tumours frequently manifest as severe physical morbidity and quality of life (QoL) impairment. The disease-related QoL measurement can be performed with disease specific questionnaires, e.g. Skull base inventory (SBI). Patients and methods: The study consisted of two parts: (1) cross-cultural adaptation and psychometric testing of the Slovenian SBI (SBI-SLO) and (2) QoL assessment in skull base tumours. Two groups completed the SBI-SLO: 1.) adult patients without prior treatment of anterior, anterolateral and/or central skull base and 2.) healthy controls. Patients with skull-base tumours were further analysed for difference in SBI-SLO total score and domain scores between 1.) benign and malignant tumours and 2.) pituitary macroadenomas and other benign tumours. Results: 59 patients (46% male, 54% female, median age 57.7 years) and 47 subjects from control group (49% male, 51% female, median age 42,2 years) completed SBI-SLO, which demonstrated an excellent level of internal consistency (Cronbach's alpha = 0.924) and excellent test-retest reliability (intraclass correlation coefficient [ICCA] = 0.952). The discriminant validity was confirmed (p = 0.000). SBI-SLO total score, emotional, other and family domain scores were lower in malignant than in benign tumours (p = 0.031, p = 0.038, p = 0.008, and p = 0.046, respectively). Macroadenoma and other benign tumours differed only in neurological domain score (p < 0.05). Conclusions: A skull base tumour, especially malignant, can exert a substantial detrimental effect on a patient's quality of life. The SBI is a key tool for assessing QoL, also available in Slovenian. |
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| Keywords: | quality of life, skull base, neoplasms, meningioma, carcinoma |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Year of publishing: | 2026 |
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| Number of pages: | str. 106-113 |
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| Numbering: | Vol. 60, iss. 1 |
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| PID: | 20.500.12556/DiRROS-29218  |
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| UDC: | 616-006 |
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| ISSN on article: | 1581-3207 |
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| DOI: | 10.2478/raon-2026-0007 |
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| COBISS.SI-ID: | 266450435 |
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| Note: | Nasl. z nasl. zaslona;
Opis vira z dne 28. 1. 2026;
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| Publication date in DiRROS: | 24.04.2026 |
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| Views: | 31 |
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| Downloads: | 14 |
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