20.500.12556/DiRROS-29218 Quality of life in Slovenian patients with skull base tumours cross-cultural adaptation and validation of a Slovenian skull base inventory Background: Skull base tumours frequently manifest as severe physical morbidity and quality of life (QoL) impairment. The disease-related QoL measurement can be performed with disease specific questionnaires, e.g. Skull base inventory (SBI). Patients and methods: The study consisted of two parts: (1) cross-cultural adaptation and psychometric testing of the Slovenian SBI (SBI-SLO) and (2) QoL assessment in skull base tumours. Two groups completed the SBI-SLO: 1.) adult patients without prior treatment of anterior, anterolateral and/or central skull base and 2.) healthy controls. Patients with skull-base tumours were further analysed for difference in SBI-SLO total score and domain scores between 1.) benign and malignant tumours and 2.) pituitary macroadenomas and other benign tumours. Results: 59 patients (46% male, 54% female, median age 57.7 years) and 47 subjects from control group (49% male, 51% female, median age 42,2 years) completed SBI-SLO, which demonstrated an excellent level of internal consistency (Cronbach's alpha = 0.924) and excellent test-retest reliability (intraclass correlation coefficient [ICCA] = 0.952). The discriminant validity was confirmed (p = 0.000). SBI-SLO total score, emotional, other and family domain scores were lower in malignant than in benign tumours (p = 0.031, p = 0.038, p = 0.008, and p = 0.046, respectively). Macroadenoma and other benign tumours differed only in neurological domain score (p < 0.05). Conclusions: A skull base tumour, especially malignant, can exert a substantial detrimental effect on a patient's quality of life. The SBI is a key tool for assessing QoL, also available in Slovenian. quality of life skull base neoplasms meningioma carcinoma kakovost življenja lobanja novotvorbe meningiom karcinom true false true Angleški jezik Slovenski jezik Neznano 2026-04-24 14:49:42 2026-04-24 14:49:42 2026-04-25 03:53:43 0000-00-00 00:00:00 2026 0 0 Nasl. z nasl. zaslona; Opis vira z dne 28. 1. 2026; str. 106-113 iss. 1 Vol. 60 2026 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616-006 1581-3207 10.2478/raon-2026-0007 266450435 RAZ_Vozel_Domen_2026.pdf RAZ_Vozel_Domen_2026.pdf 1 CDA02E6B276E94DE177278037FC79015 e903570265ca5298950067d06d596250ae94789c9c13bf62eb9a698e20c86e5e 2cc38919-3fdc-11f1-ad5f-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=43703 https://reference-global.com/article/10.2478/raon-2026-0007 1 1260e530-3fdc-11f1-ad5f-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=43702 Univerzitetni klinični center Ljubljana 0 0 0