| Title: | Vascular access for hemodialysis and right ventricular remodeling : a prospective echocardiographic study |
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| Authors: | ID Fornazarič, Denis (Author)
ID Gubenšek, Jakob (Author)
ID Antonič, Manja (Author)
ID Cvijić, Marta (Author)
ID Pajek, Jernej (Author) |
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| Files: |  PDF - Presentation file, download (946,39 KB)
MD5: EA1F33547252F9BCC65AB7D96690D297
 URL - Source URL, visit https://www.mdpi.com/2077-0383/14/15/5565
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  UKC LJ - Ljubljana University Medical Centre
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| Abstract: | Background: Arteriovenous fistulas (AVFs) may contribute to cardiac remodeling and consequently to an increased risk of heart failure and cardiovascular mortality in patients with end-stage kidney disease (ESKD). We aimed to assess cardiac changes following AVF creation and identify potential parameters associated with cardiac remodeling. Methods: In our prospective, single-center study, ESKD patients without significant pre-existing cardiac disease underwent 2D and 3D echocardiographic evaluation before and after AVF creation, along with AVF flow measurement. Cardiac remodeling was assessed using 3D indexed left and right ventricular end-diastolic volumes (LVEDVi, RVEDVi), while systolic function was assessed using longitudinal strain and 3D ejection fraction. Results: We included 20 patients (18 men; median age 73.5 years [IQR: 67-77]) with a mean AVF flow of 1140 ± 345 mL/min. At a median of 8.2 months (IQR: 7.3-9.3) following AVF creation, significant biventricular dilatation was observed: LVEDVi increased from 89 ± 14 to 97 ± 21 mL/m2 (p < 0.05) and RVEDVi from 80 ± 15 to 91 ± 18 mL/m2 (p < 0.05), while the systolic function of both ventricles did not change significantly. The right ventricle showed the most pronounced remodeling and it was independently associated with volume overload (p = 0.003) and elevated left ventricular filling pressure (p = 0.030), but not with AVF flow. Conclusions: Moderate AVF flow was associated with cardiac remodeling, primarily affecting the right ventricle. Fluid overload and left ventricular filling pressure were key factors associated with right ventricular remodeling, underscoring the need for careful fluid management and vascular access planning in ESKD patients. |
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| Keywords: | arteriovenous fistula flow, cardiac remodeling, end-stage kidney disease, three-dimensional echocardiography |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Year of publishing: | 2025 |
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| Number of pages: | str. 1-16 |
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| Numbering: | Vol. 14, iss. 15, [article no.] 5565 |
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| PID: | 20.500.12556/DiRROS-28978  |
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| UDC: | 616.1 |
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| ISSN on article: | 2077-0383 |
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| DOI: | 10.3390/jcm14155565 |
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| COBISS.SI-ID: | 263260163 |
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| Note: | Nasl. z nasl. zaslona;
Opis vira z dne 31. 12. 2025;
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| Publication date in DiRROS: | 15.04.2026 |
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| Views: | 110 |
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| Downloads: | 71 |
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