20.500.12556/DiRROS-28978 Vascular access for hemodialysis and right ventricular remodeling a prospective echocardiographic study Background: Arteriovenous fistulas (AVFs) may contribute to cardiac remodeling and consequently to an increased risk of heart failure and cardiovascular mortality in patients with end-stage kidney disease (ESKD). We aimed to assess cardiac changes following AVF creation and identify potential parameters associated with cardiac remodeling. Methods: In our prospective, single-center study, ESKD patients without significant pre-existing cardiac disease underwent 2D and 3D echocardiographic evaluation before and after AVF creation, along with AVF flow measurement. Cardiac remodeling was assessed using 3D indexed left and right ventricular end-diastolic volumes (LVEDVi, RVEDVi), while systolic function was assessed using longitudinal strain and 3D ejection fraction. Results: We included 20 patients (18 men; median age 73.5 years [IQR: 67-77]) with a mean AVF flow of 1140 ± 345 mL/min. At a median of 8.2 months (IQR: 7.3-9.3) following AVF creation, significant biventricular dilatation was observed: LVEDVi increased from 89 ± 14 to 97 ± 21 mL/m2 (p < 0.05) and RVEDVi from 80 ± 15 to 91 ± 18 mL/m2 (p < 0.05), while the systolic function of both ventricles did not change significantly. The right ventricle showed the most pronounced remodeling and it was independently associated with volume overload (p = 0.003) and elevated left ventricular filling pressure (p = 0.030), but not with AVF flow. Conclusions: Moderate AVF flow was associated with cardiac remodeling, primarily affecting the right ventricle. Fluid overload and left ventricular filling pressure were key factors associated with right ventricular remodeling, underscoring the need for careful fluid management and vascular access planning in ESKD patients. arteriovenous fistula flow cardiac remodeling end-stage kidney disease three-dimensional echocardiography arteriovenska fistula preoblikovanje srca končna ledvična bolezen tridimenzionalna ehokardiografija true false true Angleški jezik Slovenski jezik Neznano 2026-04-15 13:12:06 2026-04-15 13:12:07 2026-04-16 04:06:21 0000-00-00 00:00:00 2025 0 0 Nasl. z nasl. zaslona; Opis vira z dne 31. 12. 2025; str. 1-16 iss. 15, [article no.] 5565 Vol. 14 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.1 2077-0383 10.3390/jcm14155565 263260163 RAZ_Fornazaric_Denis_2025.pdf RAZ_Fornazaric_Denis_2025.pdf 1 EA1F33547252F9BCC65AB7D96690D297 c9dc46b0c48ccc07293042a75bb4172db7f1abcde8b4a842c0e50a0cc0793f65 1c7db41a-38bc-11f1-9cc3-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=43248 https://www.mdpi.com/2077-0383/14/15/5565 1 f2707e80-38bb-11f1-9cc3-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=43247 Univerzitetni klinični center Ljubljana 0 0 0