| Title: | Telomere length, oxidative stress, and kidney damage biomarkers in Fabry nephropathy |
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| Authors: | ID Levstek, Tina (Author)
ID Bahčič, Erazem (Author)
ID Vujkovac, Bojan (Author)
ID Cokan Vujkovac, Andreja (Author)
ID Tesovnik, Tine (Author)
ID Remec, Žiga Iztok (Author)
ID Čuk, Vanja (Author)
ID Trebušak Podkrajšek, Katarina (Author) |
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| Files: |  PDF - Presentation file, download (1,53 MB)
MD5: A39139B615625DBE80FACD0EC4CAB68C
 URL - Source URL, visit https://www.mdpi.com/2073-4409/14/3/218
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  UKC LJ - Ljubljana University Medical Centre
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| Abstract: | Fabry nephropathy is a life-threatening complication of Fabry disease characterized by complex and incompletely understood pathophysiological processes possibly linked to premature aging. We aimed to investigate leukocyte telomere length (LTL), oxidative stress, and kidney damage biomarkers in relation to kidney function. The study included 35 Fabry patients and 35 age and sex-matched control subjects. Based on the estimated slope of the glomerular filtration rate, the patients were divided into two groups. Relative LTL was quantified by qPCR, urinary biomarkers 8-hydroxy-2′ -deoxyguanosine (8-OHdG) and malondialdehyde (MDA) by UHPLC-MS/MS, and kidney damage biomarkers by flow cytometry. There was no statistically significant difference in LTL between Fabry patients and controls. However, a significant difference was observed in male patients compared to their matched control subjects (p = 0.013). Oxidative stress biomarkers showed no differences between patients and controls, while significant differences were observed in urinary IGFBP7, EGF, and OPN levels between Fabry patients with stable kidney function and those with progressive nephropathy (FDR = 0.021, 0.002, and 0.013, respectively). Significant differences were also observed in plasma levels of cystatin C, TFF3, and uromodulin between patients with progressive nephropathy and controls (all FDR = 0.039). Along with these biomarkers (FDR = 0.007, 0.017, and 0.010, respectively), NGAL also exhibited a significant difference between the two patient groups (FDR = 0.017). This study indicates accelerated telomere attrition, which may be related to disease burden in males. Furthermore, analyses of urinary oxidative stress markers revealed no notable disparities between the different kidney function groups, indicating their limited utility. However, promising differences were found in some biomarkers of kidney damage in urine and plasma. |
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| Keywords: | nephropathy, telomere length, oxidative stress, kidney damage, biomarker, aging |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Year of publishing: | 2025 |
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| Number of pages: | str. 1-15 |
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| Numbering: | Vol. 14, no. 3 |
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| PID: | 20.500.12556/DiRROS-28878  |
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| UDC: | 616-056.7 |
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| ISSN on article: | 2073-4409 |
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| DOI: | 10.3390/cells14030218 |
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| COBISS.SI-ID: | 225070339 |
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| Note: | Nasl. z nasl. zaslona;
Opis vira z dne 4. 2. 2025;
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| Publication date in DiRROS: | 10.04.2026 |
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| Views: | 126 |
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| Downloads: | 77 |
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