| Title: | Age-related effects of COVID-19 pandemic on mechanical reperfusion and 30-day mortality for STEMI : results of the ISACS-STEMI COVID-19 registry |
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| Authors: | ID De Luca, Giuseppe (Author)
ID Algowhary, Magdy (Author)
ID Uguz, Berat (Author)
ID Oliveira, Dinaldo C. (Author)
ID Ganyukov, Vladimir (Author)
ID Busljetik, Oliver (Author)
ID Čerček, Miha (Author), et al. |
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| Files: |  PDF - Presentation file, download (1,31 MB)
MD5: BB984F672035CD9B49B209667C6F7977
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  UKC LJ - Ljubljana University Medical Centre
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| Abstract: | Background: The constraints in the management of patients with ST-segment elevation myocardial infarction (STEMI) during the COVID-19 pandemic have been suggested to have severely impacted mortality levels. The aim of the current analysis is to evaluate the age-related effects of the COVID-19 pandemic on mechanical reperfusion and 30-day mortality for STEMI within the registry ISACS-STEMI COVID-19. Methods: This retrospective multicenter registry was performed in high-volume PPCI centers on four continents and included STEMI patients undergoing PPCI in March–June 2019 and 2020. Patients were divided according to age (< or ≥75 years). The main outcomes were the incidence and timing of PPCI, (ischemia time longer than 12 h and door-to-balloon longer than 30 min), and in-hospital or 30-day mortality. Results: We included 16,683 patients undergoing PPCI in 109 centers. In 2020, during the pandemic, there was a significant reduction in PPCI as compared to 2019 (IRR 0.843 (95%-CI: 0.825–0.861, p < 0.0001). We found a significant age-related reduction (7%, p = 0.015), with a larger effect on elderly than on younger patients. Furthermore, we observed significantly higher 30-day mortality during the pandemic period, especially among the elderly (13.6% vs. 17.9%, adjusted HR (95% CI) = 1.55 [1.24–1.93], p < 0.001) as compared to younger patients (4.8% vs. 5.7%; adjusted HR (95% CI) = 1.25 [1.05–1.49], p = 0.013), as a potential consequence of the significantly longer ischemia time observed during the pandemic. Conclusions: The COVID-19 pandemic had a significant impact on the treatment of patients with STEMI, with a 16% reduction in PPCI procedures, with a larger reduction and a longer delay to treatment among elderly patients, which may have contributed to increase in-hospital and 30-day mortality during the pandemic. |
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| Keywords: | ageing, ST-segment elevation myocardial infarction, COVID-19 |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Year of publishing: | 2023 |
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| Number of pages: | str. 1-14 |
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| Numbering: | Vol. 12, issue 6, [article no.] 2116 |
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| PID: | 20.500.12556/DiRROS-28732  |
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| UDC: | 616.1 |
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| ISSN on article: | 2077-0383 |
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| DOI: | 10.3390/jcm12062116 |
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| COBISS.SI-ID: | 272793859 |
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| Note: | Nasl. z nasl. zaslona;
Opis vira z dne 24. 3. 2026;
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| Publication date in DiRROS: | 31.03.2026 |
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| Views: | 84 |
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| Downloads: | 36 |
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