20.500.12556/DiRROS-28732 Age-related effects of COVID-19 pandemic on mechanical reperfusion and 30-day mortality for STEMI results of the ISACS-STEMI COVID-19 registry Background: The constraints in the management of patients with ST-segment elevation myocardial infarction (STEMI) during the COVID-19 pandemic have been suggested to have severely impacted mortality levels. The aim of the current analysis is to evaluate the age-related effects of the COVID-19 pandemic on mechanical reperfusion and 30-day mortality for STEMI within the registry ISACS-STEMI COVID-19. Methods: This retrospective multicenter registry was performed in high-volume PPCI centers on four continents and included STEMI patients undergoing PPCI in March–June 2019 and 2020. Patients were divided according to age (< or ≥75 years). The main outcomes were the incidence and timing of PPCI, (ischemia time longer than 12 h and door-to-balloon longer than 30 min), and in-hospital or 30-day mortality. Results: We included 16,683 patients undergoing PPCI in 109 centers. In 2020, during the pandemic, there was a significant reduction in PPCI as compared to 2019 (IRR 0.843 (95%-CI: 0.825–0.861, p < 0.0001). We found a significant age-related reduction (7%, p = 0.015), with a larger effect on elderly than on younger patients. Furthermore, we observed significantly higher 30-day mortality during the pandemic period, especially among the elderly (13.6% vs. 17.9%, adjusted HR (95% CI) = 1.55 [1.24–1.93], p < 0.001) as compared to younger patients (4.8% vs. 5.7%; adjusted HR (95% CI) = 1.25 [1.05–1.49], p = 0.013), as a potential consequence of the significantly longer ischemia time observed during the pandemic. Conclusions: The COVID-19 pandemic had a significant impact on the treatment of patients with STEMI, with a 16% reduction in PPCI procedures, with a larger reduction and a longer delay to treatment among elderly patients, which may have contributed to increase in-hospital and 30-day mortality during the pandemic. ageing ST-segment elevation myocardial infarction COVID-19 true false true Angleški jezik Ni določen Neznano 2026-03-31 12:24:49 2026-03-31 12:24:49 2026-04-01 03:58:42 0000-00-00 00:00:00 2023 0 0 Nasl. z nasl. zaslona; Opis vira z dne 24. 3. 2026; str. 1-14 issue 6, [article no.] 2116 Vol. 12 2023 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.1 2077-0383 10.3390/jcm12062116 272793859 RAZ_De_Luca_Giuseppe_2023.pdf RAZ_De_Luca_Giuseppe_2023.pdf 1 BB984F672035CD9B49B209667C6F7977 9e0ab9443d6a72a4ccce1a8eb58f7aca1bbfd591b86913f0114f93ae25c2997e 000f7dcf-2cec-11f1-9147-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=42750 Univerzitetni klinični center Ljubljana 0 0 0