| Title: | The association between adult IgA vasculitis and cancer : a prospective observational study |
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| Authors: | ID Hočevar, Alojzija (Author)
ID Jurčić, Vesna (Author)
ID Rotar, Žiga (Author) |
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| Files: |  PDF - Presentation file, download (434,75 KB)
MD5: 6C1F7FB964DA287A2AA299B7B9CF2ABA
 URL - Source URL, visit https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2025.1551772/full
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  UKC LJ - Ljubljana University Medical Centre
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| Abstract: | Objectives: Cancer has been reported as a potential trigger for IgA vasculitis (IgAV) in adults; however, data on this topic are scarce. The aim of our study was to examine the frequency and location of cancer in adults with IgAV. Methods: We included 295 IgAV patients diagnosed between January 2010 and June 2021 and followed at our secondary/tertiary rheumatology centre. Cancer episodes were recorded and classified into three groups according to their temporal relation to IgAV: (1) cancer diagnosed prior to IgAV; (2) cancer diagnosed concurrently with IgAV; and (3) cancer diagnosed during IgAV follow-up. The term IgAV associated with cancer (IgAV-CA) was used for IgAV cases presenting while cancer was active or diagnosed within a three-year period before or after the IgAV diagnosis. Results: Forty-seven IgAV patients (15.9%) developed a total of 56 different cancers. Of these, 43 cancers (76.8%) preceded the IgAV diagnosis, 3 cancers (5.3%) were diagnosed concurrently with IgAV, and 10 cancers (17.9%) were diagnosed during the IgAV follow-up. Twenty-two IgAV patients (7.5%) who developed a total of 24 cancers (42.9%) could be classified as IgAV-CA cases. The three most frequently diagnosed cancers in the IgAV-CA group were prostatic, renal and bladder cancer, together accounting for 50% of cancers. Age and smoking were associated with concurrent cancers, and arthritis represented a risk factor for cancer development during IgAV follow-up. Conclusion: IgAV cases associated with cancer represent 7% of adult IgAV cases. In elderly patients, careful examination of the urogenital tract is warranted when cancer is suspected. |
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| Keywords: | adult IgA vasculitis, cancer, risk factor, temporal relation, urogenital cancers |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Year of publishing: | 2025 |
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| Number of pages: | str. 1-8 |
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| Numbering: | Vol. 12, iss. , [article no.] 1551772 |
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| PID: | 20.500.12556/DiRROS-28623  |
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| UDC: | 616-002: 616-006 |
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| ISSN on article: | 2296-858X |
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| DOI: | 10.3389/fmed.2025.1551772 |
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| COBISS.SI-ID: | 271245059 |
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| Publication date in DiRROS: | 26.03.2026 |
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| Views: | 51 |
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| Downloads: | 27 |
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